A5002019326- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Metal complexes synthesis and properties
- Cholesterol and Lipid Metabolism
- Sperm and Testicular Function
- Karst Systems and Hydrogeology
- Geology and Paleoclimatology Research
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Drug Transport and Resistance Mechanisms
- Insect and Arachnid Ecology and Behavior
- Ubiquitin and proteasome pathways
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- PI3K/AKT/mTOR signaling in cancer
- Sexual Differentiation and Disorders
- Grouting, Rheology, and Soil Mechanics
- Groundwater and Watershed Analysis
- Neurobiology and Insect Physiology Research
- Ferrocene Chemistry and Applications
- Characterization and Applications of Magnetic Nanoparticles
- Catalytic Cross-Coupling Reactions
- Cytokine Signaling Pathways and Interactions
- Hippo pathway signaling and YAP/TAZ
- Sarcoidosis and Beryllium Toxicity Research
- Essential Oils and Antimicrobial Activity
Inserm
2013-2025
Clermont Université
2011-2024
Université Clermont Auvergne
2012-2024
Centre National de la Recherche Scientifique
2012-2024
Piedmont Athens Regional
2021-2023
Genetique Reproduction and Developpement
2010-2021
Centre de Recherche en Nutrition Humaine d'Auvergne
2011-2020
Hôpital Manchester
2016
Institut Pascal
2015
Centre Hospitalier Universitaire de Besançon
2012
This research highlights the chemical composition, antioxidant, anti-inflammatory and anti-proliferative activities of essential oils from leaves Ocimum basilicum, americanum, Hyptis spicigera, Lippia multiflora, Ageratum conyzoides, Eucalyptus camaldulensis Zingiber officinale. Essential were analyzed by gas chromatography–mass spectrometry chromatography–flame ionization detector. Major constituents α-terpineol (59.78%) β-caryophyllene (10.54%) for basilicum; 1, 8-cineol (31.22%), camphor...
Abstract Fourteen silver(I) complexes bearing N ‐heterocyclic carbene (NHC) ligands were prepared and evaluated for anticancer activity. Some of these found to exhibit potent antiproliferative activity toward several types human cancer cell lines, including drug‐resistant with IC 50 values in the nanomolar range. An initial investigation into mechanism death induced by this family was carried out. Cell shown result from activation apoptosis without involvement primary necrosis. In HL60...
Androgens are known to modulate many cellular processes such as cell growth and survival by binding the androgen receptor (AR) activating transcription of target genes. Recent data suggested that AR can also mediate non-transcriptional actions outside nucleus in addition its ligand-inducible factor function. Here, we describe a transcription-independent activation phosphatidylinositol 3-OH kinase (PI3-K) signaling pathway androgens. Using non-transformed androgen-sensitive epithelial cells,...
Tumor cell killer: Copper(I)–NHC [CuCl(SIMes)] shows high cytotoxicity against human cancer cells. An increase of up to 150 fold compared with cisplatin was observed. The complex causes arrest the cycle progression at G1 phase concomitantly apoptosis induction low concentration (see scheme). This copper(I)–NHC also produces DNA strand breaks, which demonstrates its value as a Fenton-like reagent. Detailed facts importance specialist readers are published "Supporting Information". Such...
The androgen receptor (AR) is a ligand-responsive transcription factor known to play central role in the pathogenesis of prostate cancer. However, regulation AR gene expression normal and pathological remains poorly understood. This study focuses on effect phosphoinositide 3-kinase (PI 3-kinase)/Akt axis vas deferens epithelial cells (VDEC), suitable model expression, LNCaP (derived from metastasis at left supraclavicular lymph node 50-year-old patient with confirmed diagnosis metastatic...
Radiation therapy plays a central role in the treatment of glioblastoma, but it is not curative due to high tumor radioresistance. Phosphatidyl-inositol 3-kinase/protein kinase B (Akt) and Janus (JAK)/signal transducer activator transcription 3 (STAT3) pathways serve block apoptosis process, keeping cells alive very toxic environments such as chemotherapy or ionizing radiation. In present study, from panel 8 human malignant glioma cell lines, investigations on relationship between intrinsic...
Basal extrusion allows an epithelial cell to leave its compartment, making it a necessary step in the local invasion of all cancers. Here, we determined which effect sex steroid deprivation plays on basal extrusion, and resulting consequences tumorigenesis. For this, blocked ecdysone signaling model tumorigenesis drosophila accessory gland, tumor-cell specific manner. As for human treatment, this induces apoptosis many preexistent tumor cells. It also slightly decreases primary formation....
In the male, androgens promote growth and differentiation of sex reproductive organs through ligand activation androgen receptor (AR). Here, we show that are not major actors cell cycle arrest associated with process, epidermal factor (EGF)-mediated signalling interferes AR activities to regulate response when epithelial cells differentiated. Higher expression enhanced responsiveness correlate reduction phosphorylated ERK1/2 over differentiation. These modifications recruitment in phase...
GRIESSER A.-C., VLASTOS G., MOREL L., BEAUME C., SAPPINO A.-P. & HALLER G. (2010) European Journal of Cancer CareSocio-demographic predictors high support needs in newly diagnosed breast cancer patients This study aimed to identify and their socio-demographic improve supportive care for patients. A cross-sectional measured patients' unsatisfied by the survey (SCNS-34), administered after surgery, chemotherapy or radiotherapy. Socio-demographic, disease treatment characteristics completed...
A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy X-ray crystallography. This cis bis acyclic diamino carbene acts as a cytotoxic compound behaves cisplatin equivalent interacting with supercoiled DNA thiols. Stability of the ligand is also discussed.
Azide-tagged Cu(I)-NHC reacts in an 'auto-click' process to furnish complexes functionalized by 1,2,3-triazoles bearing diverse substituents. The resulting Cu(I) are amenable further transmetallation Au(I). whole strategy proceeds with mild conditions and constitutes efficient entry functionalised metal-NHCs biorelevant moieties.
Radiotherapy is an essential component of glioma standard treatment. Glioblastomas (GBM), however, display important radioresistance leading to tumor recurrence. To improve patient prognosis, there a need radiosensitize GBM cells and circumvent the mechanisms resistance caused by interactions between their microenvironment. STAT3 has been identified as therapeutic target in because its involvement sustaining escape both treatment immune control. Here, we studied role activation on tyrosine...
Abstract One of the most important but less understood step epithelial tumourigenesis occurs when cells acquire ability to leave their compartment. This phenomenon, described as basal cell extrusion (basal extrusion), represents first tumour invasion. However, due lack adequate in vivo model, implication emblematic signalling pathways such Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein B (AKT)/mammalian target rapamycin (mTOR) pathways, is scarcely...
The proto-oncoprotein Cbl is known to control several signaling processes. It highly expressed in the testis, and because spermatogenesis androgen dependent, we investigated dependency expression of through its testicular sublocalization levels rats that were exposed antiandrogen flutamide or hypophysectomized. We report as it localizes pachytene spermatocytes during androgen-dependent stages, down-regulated upon exposure, up-regulated with testosterone hypophysectomized rats. Coculture...
Abstract Complexes of the type [PdX(PPh 3 )( 1 )]X [ = 4‐phenyl‐3‐thiosemicarbazide; X Cl – ( 2 ), Br I 4 and SCN 5 )] have been synthesized characterized by elemental analyses IR, UV/Vis, H 13 C NMR spectroscopy. The molecular structure complex was determined single‐crystal X‐ray diffraction. binding complexes with a purine base (guanosine) investigated spectroscopy mass spectrometry, which showed to coordinate guanosine through N7. A gel electrophoresis assay demonstrated ability cleave...
The chaperone nucleophosmin (NPM1) is over-expressed in the epithelial compartment of prostate tumours compared to adjacent healthy epithelium and may represent one key actors that support neoplastic phenotype adenocarcinoma cells. Yet, mechanisms underlie NPM1 mediated remain elusive prostate. To better understand functions cancer cells, we sought characterize its impact on cells behaviour decipher by which it act. Here show favors tumour cell migration, invasion colony forming....