A5070668061- Polyamine Metabolism and Applications
- Cancer-related gene regulation
- Amino Acid Enzymes and Metabolism
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Advanced Radiotherapy Techniques
- Prostate Cancer Diagnosis and Treatment
- Estrogen and related hormone effects
- Sphingolipid Metabolism and Signaling
- Cancer, Hypoxia, and Metabolism
- Pancreatic function and diabetes
- Lipid metabolism and biosynthesis
- Hippo pathway signaling and YAP/TAZ
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Muscle Physiology and Disorders
- Hormonal and reproductive studies
- Sirtuins and Resveratrol in Medicine
- Thyroid Disorders and Treatments
Inserm
1988-2024
Université Côte d'Azur
2006-2024
Centre National de la Recherche Scientifique
2006-2024
Institut de Pharmacologie Moléculaire et Cellulaire
2023-2024
Target (United States)
2021
Prostate Cancer Research
2021
Centre Méditerranéen de Médecine Moléculaire
2016-2020
Centre Intégré de Santé et de Services Sociaux des Laurentides
2020
Laboratoire de physiologie cellulaire et moléculaire
2006
Université Clermont Auvergne
1997-2003
Muscle atrophy is a debilitating process associated with many chronic wasting diseases, like cancer, diabetes, sepsis, and renal failure.Rapid loss of muscle mass occurs mainly through the activation protein breakdown by ubiquitin proteasome pathway.Foxo3a transcription factor critical for atrophy, since it activates expression ligase Atrogin-1.In several models inhibition phosphatidylinositol 3kinase (PI3K)/Akt signaling pathway induces nuclear import Foxo3a an Akt-dependent process.This...
Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin an disruptor targeting complex I respiratory chain. We demonstrate that metformin induces endoplasmic reticulum (ER) stress, calcium release from ER subsequent uptake into mitochondria, thus leading to mitochondrial swelling. triggers disorganization cristae inner membrane in several cancer cells tumors. Mechanistically, these alterations were found be due entry because swelling induced by was...
Abstract Although tumorigenesis is dependent on the reprogramming of cellular metabolism, metabolic pathways engaged in formation metastases remain largely unknown. The transcriptional coactivator peroxisome proliferator-activated receptor gamma 1-alpha (PGC1α) plays a pleiotropic role control cancer cell metabolism and has been associated with good prognosis prostate cancer. Here, we show that PGC1α represses metastatic properties cells via modulation polyamine biosynthesis pathway....
Predictive biomarkers for advanced prostate cancer (PCa) are still missing. The sirtuin 7 (SIRT7) has been linked to tumorogenesis but its role in is poorly documented. To determine if SIRT7 can be a biomarker aggressive and plays PCa aggressiveness. We analyzed the expression of by immunohistochemistry 57 patients comparing healthy with adjacent tissue. levels were significantly elevated tumors was positively associated grade. also demonstrated that knock down decreased migration DU145 PC3...
: Renal cell carcinoma (RCC) accounts for about 2% of all adult cancers, and clear RCC (ccRCC) is the most common histologic subtype. A hallmark ccRCC loss primary cilium, a cellular antenna that senses wide variety signals. Loss this key organelle in associated with von Hippel-Lindau protein (VHL). However, not mechanisms ciliopathy have been clearly elucidated.
To adapt in an ever-changing environment, cells must integrate physical and chemical signals translate them into biological meaningful information through complex signaling pathways. By combining lipidomic proteomic approaches with functional analysis, we have shown that ubiquitin domain-containing protein 1 (UBTD1) plays a crucial role both the epidermal growth factor receptor (EGFR) self-phosphorylation its lysosomal degradation. On one hand, by modulating cellular level of ceramides...
Patients can only examine and handle their own feet if they have adequate visual acuity joint mobility. We therefore studied the physical capacity of patients with neuropathy to perform preventive footcare measures previously taught. The study included three groups diabetic oupatients, comparable for age duration diabetes: (1) 38 neuropathic ulcers; (2) 21 neuropathy, but no (3) 30 without neuropathy. Visual mobility, expressed as minimum eye—metatarsum heel—buttock distances, did not differ...
Stimulating anti-TSH receptor antibodies (TSAb) mimic TSH in the induction of refractoriness cultured thyroid cells; TSAb and desensitize one another. We investigated whether blocking (TBkAb) have same desensitizing effects human cells. Prolonged exposure cells (20 h) to TBkAb followed by antigen-antibody dissociation an acid wash step was required induce subsequent stimulation cAMP accumulation with TSAb. Cycloheximide prevented this desensitization effect. The response forskolin not...
Biomolecular condensates regulate a wide range of cellular functions from signaling to RNA metabolism 1, 2 , yet, the physiologic conditions regulating their formation remain largely unexplored. condensate assembly is tightly regulated by intracellular environment. Changes in chemical or physical inside cells can stimulate inhibit 3-5 . However, whether and how external environment also biomolecular condensation poorly understood. Increasing our understanding these mechanisms paramount as...
Large prospective studies established a link between obesity and breast cancer (BC) development. Yet, the mechanisms underlying this association are not fully understood. Among diverse adipocytokine secreted by hypertrophic adipose tissue, leptin is emerging as key candidate molecule linking cancer, since it promotes proliferation invasiveness of tumors. However, potential implication on tumor escape remains unknown. This study aims to explore effect resistance NK lysis mechanism. We found...