A5076779809- Effects and risks of endocrine disrupting chemicals
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
- Prostate Cancer Treatment and Research
- Essential Oils and Antimicrobial Activity
- Cancer, Lipids, and Metabolism
- Sperm and Testicular Function
- Phytochemical compounds biological activities
- Natural product bioactivities and synthesis
- Extracellular vesicles in disease
- Toxic Organic Pollutants Impact
- Estrogen and related hormone effects
- Molecular Biology Techniques and Applications
- Tannin, Tannase and Anticancer Activities
- Drug Transport and Resistance Mechanisms
- Protein Kinase Regulation and GTPase Signaling
- Eicosanoids and Hypertension Pharmacology
- Ethnobotanical and Medicinal Plants Studies
- Carcinogens and Genotoxicity Assessment
- Cancer Cells and Metastasis
- Ovarian function and disorders
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Traditional and Medicinal Uses of Annonaceae
- Hormonal Regulation and Hypertension
Centre de Recherche en Nutrition Humaine d'Auvergne
2018-2024
Genetique Reproduction and Developpement
2020-2024
Université Clermont Auvergne
2018-2024
Inserm
2018-2024
Centre National de la Recherche Scientifique
2018-2024
Clermont Université
2018-2023
University of Koudougou
2023
Centre de Recherche en Cancérologie de Toulouse
2022-2023
Université Toulouse III - Paul Sabatier
2022
La Ligue Contre le Cancer
2022
Abstract Endocrine-disrupting chemicals (EDCs) are exogenous compounds that modify hormone biosynthesis, causing adverse effects to human health. Among them, phthalates and alkylphenols important due their wide use in plastics, detergents, personal care products, cosmetics, food packaging. However, conjoint over reproductive female health have not been addressed. The aim of this work was test the effect chronically exposed mice a mixture three [bis (2-ethylhexyl), dibutyl, benzyl butyl] two...
Cancer incidence and mortality rates are increasing worldwide. treatment remains a real challenge for African countries, especially in sub-Saharan Africa where funding resources very limited. High costs, side effects drug resistance associated with cancer have encouraged scientists to invest research into new herbal drugs. In order identify potential anticancer plants development, this review aims collect summarize activities (in vitro/in vivo) molecular mechanisms of medicinal plant...
Abstract Humans are environmentally exposed not only to single endocrine-disrupting chemicals (EDCs) but mixtures that affect their reproductive health. In tissues, microRNAs (miRNAs) emerging as key targets of EDCs. Here, we analysed changes in the testis “miRNome” (and biogenesis mechanism) chronically adult mice a cocktail five EDCs containing 0.3 mg/kg-body weight (BW)/day each phthalate (DEHP, DBP, BBP) and 0.05 mg/kg-BW/day alkylphenol (NP, OP), from conception adulthood. The was...
Endocrine-disrupting chemicals (EDCs) generate reproductive dysfunctions affecting the biosynthesis of steroid hormones and genes steroidogenic pathway. EDCs effects are mainly reported as a result exposure to single compounds. However, humans environmentally exposed mixture EDCs. Herein, we assess chronic alkylphenols phthalates versus in mouse testes histology steroidogenesis. Pregnant mice were through drinking water to: 0.3 mg/kg-body weight (BW)/d each phthalate (bis (2-ethylhexyl)...
Abstract Tumour cells are characterized by having lost their differentiation state. They constitutively secrete small extracellular vesicles (sEV) called exosomes when they come from late endosomes. Dendrogenin A (DDA) is an endogenous tumour suppressor cholesterol‐derived metabolite. It a new class of ligand the nuclear Liver X receptors (LXR) which regulate cholesterol homeostasis and immunity. We hypothesized that DDA, induces cell differentiation, inhibition growth immune infiltration...
Abstract One of the most important but less understood step epithelial tumourigenesis occurs when cells acquire ability to leave their compartment. This phenomenon, described as basal cell extrusion (basal extrusion), represents first tumour invasion. However, due lack adequate in vivo model, implication emblematic signalling pathways such Ras/Mitogen-Activated Protein Kinase (MAPK) and phosphoinositide 3 kinase (PI3K)/protein B (AKT)/mammalian target rapamycin (mTOR) pathways, is scarcely...
The increase in male idiopathic infertility has been associated with daily exposure to endocrine disruptors chemicals (EDCs). Nevertheless, the mechanisms of action relation dysregulating proteins and regulatory microRNAs are unknown. We combined proteomic miRNome analyses mouse testis chronically exposed low doses a define mixture EDCs [phthalates: bis(2-ethylhexyl), dibutyl benzyl-butyl; 4-nonylphenol 4-tert-octylphenol], administered drinking water from conception until adulthood...
Obesity is a major worldwide health problem that related to most chronic diseases, including male infertility. Owing its wide impact on health, mechanisms underlying obesity-related infertility remain unknown. In this study, we report mice fed high-fat diet (HFD) for over 2 months showed reduced fertility rates and increased germ cell apoptosis, seminiferous tubule degeneration, decreased intratesticular estradiol (E2) E2-to-testosterone ratio. Interestingly, also detected decrease in...
The aim of this research was to evaluate the essential oil Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in terms cytotoxic activity against LNCaP cells, derived prostate cancer, and HeLa cervical cancer. Antioxidant activities were evaluated vitro. Essential (EO) extracted by hydrodistillation analyzed GC/FID GC/MS. Thirty-seven compounds identified, major being piperitone (49.9%), δ-2-carene (24.02%), elemol (5.79%) limonene (4.31%). EO exhibited a poor...
Mill. is a Mediterranean aromatic plant largely used, in addition to its nutritional value, traditional medicine as antiseptic, antifungal, antituberculotic, and antirheumatic. Thus, the objective of this work was appraise antioxidant cytotoxic activity essential oil (EO)
Reproductive hormone imbalance in infertile women is correlated to high levels of phthalates and alkylphenols, which are among endocrine-disrupting chemicals (EDCs). Previous studies have shown that they interfere with gene expression by deregulating microRNAs (miRs), small non-coding RNAs targeting mRNAs encoding enzymes the biosynthesis pathway. However, this effect depends on target organ, dose whether or not alone mixtures. Our goal was study biosynthesis, a specific group miRs steroid...
Normal cells secrete small extracellular vesicles (sEV), containing exosomes and/or ectosomes, which play a beneficial role in monitoring tissue integrity and immune response, whereas cancer constitutively sEV, contribute to inhibit the defenses promote tumor progression aggressiveness. Therefore, there is great interest reprograming sEV functions toward normal ones. We hypothesized that this could be realized by inducing cell re-differentiation with dendrogenin A (DDA), an endogenous...
The aim of this research was to evaluate the essential oil Cymbopogon schoenanthus (L.) Spreng. (C. schoenanthus) from Burkina Faso in cytotoxic activity against LNCaP cells, derived prostate cancer, and HeLa cervical cancer. Antioxidant activities were evaluated vitro. Essential (EO) extracted by hydrodistillation analyzed GC / FID MS. Thirty-seven compounds identified, major being piperitone (49.9%), alpha terpinene isomer (24.02%), elemol (5.79%) limonene (4.31%). EO exhibited a poor...
Chronic inflammation is now a well-known precursor for cancer development. Infectious prostatitis are the most common causes of prostate inflammation, but emerging evidence points role metabolic disorders as potential source cancer-related inflammation. Although widely used treatment based on androgen deprivation therapy (ADT) effectively decreases tumor size, it also profound alterations in immune microenvironment within prostate. Here, we demonstrate that prostates mouse model invalidated...
Elevated intratesticular levels of hydroxyoestradiols and methoxyoestradiols, two classes endogenous oestradiol metabolites, have been associated with male infertility. The aim this study was to explore the effects 2-hydroxyoestradiol (2OHE2 ), 4-hydroxyoestradiol (4OHE2 2-methoxyoestradiol (2ME2 ) 4-methoxyoestradiol (4ME2 on Sertoli cell viability. For this, TM4 cells were incubated different concentrations these metabolites for 24 h then evaluate viability DNA integrity by MTS TUNEL assay...