A5066314754- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Ear and Head Tumors
- Cancer Research and Treatments
- Cervical Cancer and HPV Research
- Virus-based gene therapy research
- Reconstructive Facial Surgery Techniques
- Colorectal and Anal Carcinomas
- Photodynamic Therapy Research Studies
- Oral and Maxillofacial Pathology
- RNA Interference and Gene Delivery
- Nonmelanoma Skin Cancer Studies
- Nanoplatforms for cancer theranostics
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Oral health in cancer treatment
- Facial Nerve Paralysis Treatment and Research
- Cancer and Skin Lesions
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- Advanced Radiotherapy Techniques
- Healthcare Systems and Practices
Centre National de la Recherche Scientifique
2005-2025
Institut de Cancérologie de Lorraine
2016-2025
Université de Lorraine
2012-2025
Centre de Recherche en Automatique de Nancy
2015-2024
Délégation Centre-Est
2009-2020
Centre d'expertise et de recherche en infrastructures urbaines
2004-2020
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2020
Centre Hospitalier Universitaire de Grenoble
2020
Centre Hospitalier Régional et Universitaire de Nancy
2017
Guy's and St Thomas' NHS Foundation Trust
2017
Purpose Full-dose reirradiation combined with chemotherapy has been shown to be feasible after salvage surgery acceptable toxicity. The Groupe d’Etude des Tumeurs de la Tête et du Cou and d’Oncologie Radiothérapie Et groups performed a randomized study assess its efficacy. Patients Methods Between 1999 2005, 130 patients head neck cancer were treated randomly assigned full-dose (RT arm) or observation (a “wait see” approach; WS arm). Eligibility criteria recurrence second primary tumor in...
Sentinel node (SN) biopsy is accurate in operable oral and oropharyngeal cT1-T2N0 cancer (OC), but, to our knowledge, the oncologic equivalence of SN neck lymph dissection (ND; standard treatment) has never been evaluated.In this phase III multicenter trial, 307 patients with OC were randomly assigned (1) ND arm or (2) (experimental arm: alone if negative, followed by positive, during primary tumor surgery). The outcome was recurrence-free survival (RFS) at 2 years. Secondary outcomes 5-year...
Background: Treatment of head and neck cancers allows good carcinologic results but induces aesthetic functional sequelae. Autologous fat transplants have been used to correct defects since the past century exhibit many qualities ideal filler. Results reported here stem from experiences 2000, with abdominal grafting in 11 patients who were referred authors' center for subcutaneous or submucous reconstruction after radiotherapy. Methods: Abdominal tissues harvested, injection into host sites...
The aim of this study was to confirm the efficacy temoporfin (Foscan)-mediated photodynamic therapy (PDT) in patients with end-stage head and neck squamous cell carcinoma (HNSCC).Thirty-nine recurring HNSCC lesions ≤10 mm depth were injected temoporfin, followed by illumination tumor surface.Of 39 treated patients, 19 achieved complete response, 2 partial 5 stable disease, had progressive 8 nonevaluable. Thus, per-protocol analysis, response rate 68%. Of 54% a response. Median survival...
Purpose Beside its efficacy in cancer treatment, radiotherapy induces degeneration of healthy tissues within the irradiated area. The aim this study was to analyze variations proinflammatory (IL-1α, IL-2, IL-6, TNF-α, IFN-γ), profibrotic (TGF-β1), proangiogneic (VEGF) and stem cell mobilizing (GM-CSF) cytokines growth factors an animal model radiation-induced tissue degeneration. Materials Methods 24 rats were unilaterally on hindlimb at a monodose 30 Gy. Six weeks (n = 8), 6 months 8) 1...
Abstract Purpose: Use of circulating tumor DNA (ctDNA) for diagnosis is limited regarding the low number target molecules in early-stage tumors. Human papillomavirus (HPV)–associated carcinomas represent a privileged model using viral (ctHPV DNA) as marker. However, plurality HPV genotypes represents challenge. The next-generation sequencing (NGS)-based CaptHPV approach able to characterize any sequence. To assess ability this method establish HPV-associated cancer via blood sample, we...
Poromas are benign and slow-growing lesions originating from the sweat glands. They occur in elderly, without gender predominance. This article describes rare case of a patient presenting poroma on right inner canthus. An 83-year-old presented with lesion canthus, which was thought to be basal cell carcinoma. After surgical excision histological analysis, turned out poroma, an extremely localization. various presentations, can turn malignant. The malignant form is called porocarcinoma....
Distant metastasis in head and neck cancer are one of the first factors contributing to death. Currently, it is difficult detect them early with our conventional techniques such as Positron Emission Tomography scanner (PET-scanner) Magnetic Resonance Imaging (MRI). Therefore, important find new markers that can help us care patient. This study aimed at comparing two methods (Reverse Transcription-Polymerase Chain Reaction CellSearch) circulating tumor cells (CTC) a prognosticator. Results...
Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively cancer cells have some limitations. They are compact aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient matrix (ECM) deposition absence different types stromal cells. In order to better mimic in vivo HNSCC microenvironment, we constructed a stroma-rich vitro model HNSCC, using cancer-associated MeWo skin fibroblasts FaDu...
La trasposizione di lembi liberi microvascolari rappresenta oggi la procedura maggiormente diffusa nelle ricostruzioni del distretto testacollo. Tuttavia, non tutti i pazienti sono candidati ideali per microvascolari, né difetti richiedono necessariamente ottenere buoni risultati funzionali. Lo scopo questo studio è quello valutare se ricostruzione testa-collo mediante peduncolati sia inferiore alle in termini complicanze, outcome funzionale e prognosi. In una coorte consecutivi che stati...
Photochemical internalization (PCI) technology has been used for PEI-mediated p53 gene transfer in mice bearing head and neck squamous cell carcinoma (HNSCC) xenografts. Using luciferase as a reporter gene, PCI led to 20-fold increase transgene expression 48 h after transfection sustained 7 days. Therefore, iterative was performed by means of weekly single injection PEIGlu4/p53 complexes alone or with 5 (group A) B) weeks. The efficiency therapy evaluated following tumor growth P53-related...
Purpose: To assess lymph node invasion through the use of sentinel biopsy (SLNB) in conjunctival and eyelid tumor patients ascertain impact this technique therapeutic management recommended by multidisciplinary consensus committee. Methods: A single center prospective nonrandomized clinical study was conducted between January 2008 2010. Seventeen were included: 4 (2 conjunctiva 2 eyelid) melanomas, Merkel cell tumors, 8 conjunctiva, eyelid, cornea conjunctiva) squamous 1 meibomian carcinoma....