A5010931431- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Cancer Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Reconstructive Facial Surgery Techniques
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Radiomics and Machine Learning in Medical Imaging
- Colorectal and Anal Carcinomas
- Oral and Maxillofacial Pathology
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cleft Lip and Palate Research
- Tumors and Oncological Cases
- Oral health in cancer treatment
- HER2/EGFR in Cancer Research
- Sarcoma Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Multiple and Secondary Primary Cancers
Institut Gustave Roussy
2015-2024
Université Paris-Saclay
2016-2023
Stanford University
2021
Institut Sainte Catherine
2021
Helmholtz Zentrum München
2018
Université Paris-Sud
2017
Tata Memorial Hospital
2015
Ruby Hall Clinic
2015
GlaxoSmithKline (United Kingdom)
2015
Laboratoire d'études sur les monothéismes
2011
Overexpression of epidermal growth factor receptor (EGFR) is common in head and neck squamous cell carcinoma (HNSCC). Recent studies showed that EGFR inhibitors are effective for patients with HNSCC. This study analyzed the genetic nature gene HNSCC its clinical correlations.The copy numbers 134 tumors were determined using quantitative real-time polymerase chain reaction. The status was parameters including outcome. Mutation exons 18, 19, 21 tumors.Aberrant found 32 (24%) tumors, 22 (17%)...
Abstract Background The head and neck/oral squamous cell carcinoma (HNOSCC) is a diverse group of cancers, which develop from many different anatomic sites are associated with risk factors genetic characteristics. oral tongue (OTSCC) one the most common types HNOSCC. It significantly more aggressive than other forms HNOSCC, in terms local invasion spread. In this study, we aim to identify specific transcriptomic signatures that OTSCC. Results Genome-wide profiles were obtained for 53 primary...
Abstract BACKGROUND. Podoplanin is a mucin‐like glycoprotein that important in lymphangiogenesis but not blood vessel formation. Recent studies suggested potential role of podoplanin certain tumor cells. The purpose the current study was to determine head and neck squamous cell carcinoma (HNSCC). METHODS. expression analyzed 35 patients with HNSCC including 16 oral tumors 19 hypopharyngeal by immunohistochemical analysis association between status patients' clinical pathologic...
Primary head and neck mucosal melanoma (HNMM) has a poor prognosis with low local control rate frequent distant metastases. The objective of the current study was to determine impact postoperative radiotherapy on survival.One hundred forty-two patients primary HNMM treated between 1979 1997 were reviewed. Of these, 69 confirmed melanoma, absence metastatic disease, definitive management by surgery or without follow-up at Institut Gustave-Roussy (Villejuif) selected. site sinonasal in 46...
Salivary duct carcinoma (SDC), a rare malignancy, manifests remarkable morphologic and biologic resemblance to high-grade mammary ductal carcinoma. We contend that, similar carcinoma, hormones growth factors may play role in SDCs. Our aim was determine the incidence clinical significance of expression several hormone factor receptors evaluate their potential therapeutic stratification SDC patients largest cohort studied date. Eighty-four archived tumor tissue blocks were analyzed...
Objective: To report patterns of failure according to treatment modality, with an emphasis on the role postoperative radiotherapy in patients localized head and neck mucosal melanoma (HNMM) treated during a 28-year period multi-institutional setting.Design: Retrospective review.Setting: French medical institutions.Patients: A total 160 nonmetastatic HNMM from 1980 through 2008.Interventions: Treatment modality consisted surgery alone (hereinafter, S group) (n=82 patients) or SRT...
This multicenter phase III study evaluated the efficacy and safety of lapatinib, an epidermal growth factor receptor/ErbB2 inhibitor, administered concomitantly with chemoradiotherapy as maintenance monotherapy in patients high-risk surgically treated squamous cell carcinoma head neck (SCCHN).Patients resected stage II to IVA SCCHN, a surgical margin ≤ 5 mm and/or extracapsular extension, were randomly assigned (66 Gy total radiation dose cisplatin 100 mg/m(2) per day on days 1, 22, 43) plus...
PURPOSE: To determine whether p53 gene status predicts tumor responses to platinum- and fluorouracil-based induction chemotherapy in locoregionally advanced squamous cell carcinomas of the head neck. PATIENTS AND METHODS: Tumor 105 patients were measured at primary site. Objective response major defined by a 50% 80% reduction size, respectively. All coding parts directly sequenced. expression cells was determined immunohistochemistry. Human papillomavirus infection detected polymerase chain...
To establish relationships between smoking status and human papillomavirus in head neck squamous cell carcinomas.Human was detected paraffin-embedded samples using E6-directed consensus primers type-specific oligonucleotide probes. Patients were classified as smokers nonsmokers. Alcohol use also recorded. Data analyzed by means of the Fisher exact test. Sequence analysis exons 5 to 8 p53 gene performed tumor from nonsmokers.Academic medical center Paris, France.One hundred eighty-seven...
Abstract Background Nasopharyngeal carcinoma (NPC) is a human epithelial malignancy consistently associated with the Epstein-Barr virus. The viral genome contained in nuclei of all malignant cells abundant transcription family microRNAs called BART miRNAs. MicroRNAs are well known intra-cellular regulatory elements gene expression. In addition, they often exported extra-cellular space and sometimes transferred recipient distinct from producer cells. Extra-cellular transport facilitated by...
Lapatinib is a dual inhibitor of epidermal growth factor receptor (EGFR) and human EGFR-2 (HER-2) tyrosine kinases. This study investigated the pharmacodynamic clinical effects lapatinib in patients with locally advanced squamous cell carcinoma head neck (SCCHN). In total, 107 therapy-naive SCCHN were randomised (2 : 1) to receive or placebo for 2–6 weeks before chemoradiation therapy (CRT). Endpoints included apoptosis proliferation rates, response, toxicity. Versus placebo, monotherapy did...
Salvage surgery after concomitant chemoradiation therapy (CCRT) for patients with head and neck squamous cell carcinomas (HNSCC) is challenging because of its associated morbidity/mortality the poor prognoses these patients.The outcome analysis prospectively collected data from 93 HNSCC local and/or regional shows treatment failures but without distant metastasis CCRT.Thirty-eight underwent salvage surgery, whereas 55 palliative treatment, 2-year overall survival rates 43.4% 0%,...
Antiprogrammed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) therapies have demonstrated promising activity in advanced head and neck squamous carcinoma (HNSCC), with overall response rates of approximately 20% unselected populations survival benefit. Whether induction docetaxel, platinum fluorouracil (TPF) modifies PD-L1 expression or tumour immune infiltrates is unknown.Patients locally HNSCC treated at Gustave Roussy (Villejuif, France) between 2006 2013 by TPF followed surgery were...
Abstract Objectives/Hypothesis: To evaluate the reliability of sentinel node (SN) biopsy in early oral squamous cell carcinomas. Study Design: Prospective cohort study. Methods: We conducted a primary prospective study on 53 consecutive patients presenting T1, T2 N0 carcinomas cavity between January 2000 and June 2003. Primary results demonstrated negative predictive value 100%. The series was then extended until 2010, with total number 166 successful procedures. Results: accounted for 118...
Regional lymph node metastasis is a critical event in oral tongue squamous cell carcinoma (OTSCC) progression. The identification of biomarkers associated with the metastatic process would provide prognostic information to facilitate clinical decision making for improved management OTSCC patients. Global expressional profiles were obtained 25 primary OTSCCs, where 11 cases showed (pN+) histologically and 14 nonmetastatic (pN-). Seven pN+ also exhibited extracapsular spread (ECS) nodes....
Abstract Background. The purpose of this study is to review our experience with the use facial artery musculo‐mucosal (FAMM) flap for floor mouth (FOM) reconstruction following cancer ablation assess its reliability, associated complications, and functional results. Methods. This was a retrospective analysis 61 FAMM flaps performed FOM from 1997 2006. Results. No total loss observed. Fifteen cases partial necrosis occurred, 2 them requiring revision surgery. We encountered 8 other 4 surgery...
Indications for preservation of orbital contents in case malignant sinonasal tumors invading the orbit remain controversial.A retrospective consecutive review was conducted patients a tertiary care center over 15-year period.Ninety-three were diagnosed with tumor orbit. Eighty-three treated curative intent which 58 underwent surgery. Mean follow-up 45 months. Orbital feasible 66% cases, whereas clearance performed cases locally advanced disease (invasion extraocular muscles, ocular globe, or...