A5081337349- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Head and Neck Cancer Studies
- Voice and Speech Disorders
- Salivary Gland Tumors Diagnosis and Treatment
- Parathyroid Disorders and Treatments
- Thyroid and Parathyroid Surgery
- Head and Neck Surgical Oncology
- Muscle Physiology and Disorders
- Medical Imaging and Pathology Studies
- Neurogenetic and Muscular Disorders Research
- Esophageal and GI Pathology
- Thyroid Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Airway Management and Intubation Techniques
- Oral and Maxillofacial Pathology
- Head and Neck Anomalies
- Genetic Neurodegenerative Diseases
- Neuroendocrine Tumor Research Advances
- Bone health and treatments
- Child Nutrition and Feeding Issues
- Medical Imaging Techniques and Applications
- Tumors and Oncological Cases
- Salivary Gland Disorders and Functions
Clinique Hartmann
2020-2024
Sorbonne Université
2014-2023
Hôpital Tenon
2014-2023
Assistance Publique – Hôpitaux de Paris
2013-2022
Inserm
2000-2022
Centre de Recherche en Myologie
2013-2022
Université Paris 1 Panthéon-Sorbonne
2020
Hôpital Robert-Debré
2018
Sorbonne Paris Cité
2018
Centrale Marseille
2017
We compared (18)F-fluorocholine hybrid positron emission tomography/X-ray computed tomography (FCH-PET/CT) with ultrasonography (US) and scintigraphy in patients hyperparathyroidism discordant, or equivocal results of US (123)I/(99m)Tc-sesta-methoxyisobutylisonitrile (sestaMIBI) dual-phase parathyroid scintigraphy. FCH-PET/CT was performed 17 primary (n = 11) lithium induced 1) secondary (1 dialyzed, 4 renal-transplanted).The reference standard based on surgical exploration histopathological...
Context: Preoperative ultrasonography and scintigraphy using 99mTc-sestamibi are commonly used to localize abnormal parathyroid glands. In cases of discrepant results between ultrasonography, it is important rely on another diagnostic imaging modality. 18F-fluorodeoxyglucose (FDG) 11C-methionine positron emission tomography (PET) have been studied, but imperfect detect Recently, first glands taking-up radiolabelled choline were discovered incidentally in men referred 11C-choline or...
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset autosomal dominant genetic disease mainly characterized by ptosis and dysphagia. We conducted phase I/IIa clinical study (ClinicalTrials.gov NCT00773227) using autologous myoblast transplantation following myotomy in adult OPMD patients. This included 12 patients with diagnosis of OPMD, indication for cricopharyngeal myotomy, confirmed diagnosis. The feasibility safety end points both the surgical procedure were assessed...
PURPOSE: To determine whether p53 gene status predicts tumor responses to platinum- and fluorouracil-based induction chemotherapy in locoregionally advanced squamous cell carcinomas of the head neck. PATIENTS AND METHODS: Tumor 105 patients were measured at primary site. Objective response major defined by a 50% 80% reduction size, respectively. All coding parts directly sequenced. expression cells was determined immunohistochemistry. Human papillomavirus infection detected polymerase chain...
Oculopharyngeal muscular dystrophy (OPMD) is an autosomal dominant adult-onset disease characterized by progressive ptosis, dysphagia, and proximal limb weakness. The genetic cause expanded (GCN)n mutation in the PABPN1 gene encoding for polyadenylate-binding protein nuclear 1. We hypothesized a potential correlation between size of expansion severity phenotype. To do this, we distribution genotypes as well their with age at diagnosis phenotypical features large cohort heterozygous...
Abstract Background Fibrosis is defined as an excessive accumulation of extracellular matrix (ECM) components. Many organs are subjected to fibrosis including the lung, liver, heart, skin, kidney, and muscle. Muscle occurs in response trauma, aging, or dystrophies impairs muscle function. represents a hurdle for treatment human muscular dystrophies. While data on mechanisms have mostly been investigated mice, dystrophic mouse models often do not recapitulate observed patients. Consequently,...
Abstract Context Primary hyperparathyroidism (PHPT) is commonly diagnosed in the setting of hypercalcemia, whereas normocalcemic primary (NHPT) may be misdiagnosed. Objective Our objective was to compare patients with hypercalcemic (HPHPT) vs NHPT hypercalciuric renal stones. Methods We took advantage a routine calcium load test performed stones assess retrospectively among PHPT prevalence and characteristics HPHPT under calcium-restricted diet Results Among 1671 hypercalciuria, 91 had final...
Abstract Objective: The purpose of the current report is to evaluate ability videoendoscopic swallowing study in assessing pharyngeal propulsion and aspiration episodes when compared with videofluoroscopy manometry. Study Design: Prospective study. Methods: Thirty‐four patients oropharyngeal dysphagia underwent videoendoscopy assess as pathologic or non‐pathologic, aspiration. These features were those found on manometry videofluoroscopy, which considered reference examinations. Sensitivity,...
Thirty-four patients with an identified muscular disease were referred to our department for assessment and treatment of swallowing difficulties. Their ages ranged from 16 91 years (mean 59). The diagnoses oculopharyngeal dystrophy in 17 patients, Steinert myotonic 6, mitochondrial myopathies 4, polymyositis 3, other types 4 patients. main consequences the dysphagia weight loss (12 patients), pulmonary infections (15 modified food consistency (18 patients) non-oral feeding (3 patients)....
Oculopharyngeal muscular dystrophy (OPMD) is a late-onset autosomal dominant inherited caused by an abnormal trinucleotide repeat expansion in the poly(A)-binding-protein-nuclear 1 (PABPN1) gene. Primary targets of OPMD are eyelid elevator and pharyngeal muscles, including cricopharyngeal muscle (CPM), progressive involution which leads to ptosis dysphagia, respectively. To understand consequences PABPN1 polyalanine OPMD, we studied biopsies from 14 patients, 3 inclusion body myositis 9...
This study assesses the efficacy of Geriatric Assessment (GA)-driven interventions and follow-up on six-month mortality, functional, nutritional status in older patients with head neck cancer (HNC). HNC aged 65 years or over were included between November 2013 September 2018 by 15 Ear, Nose, Throat (ENT) maxillofacial surgery departments at 13 centers France. The was an open-label, multicenter, randomized, controlled, parallel-group design, independent outcome assessments. randomized 1:1 to...
A review of the postoperative course, complications, and functional outcome 69 elderly patients (older than 65 years age) consecutively managed with a supracricoid partial laryngectomy between 1977 1993 is presented. The tumors were glottic supraglottic in origin 53 16 patients, respectively. cricohyoidoepiglottopexy, tracheo-cricohyoidoepiglottopexy, cricohyoidopexy performed 48, five, Immediate laryngeal, cervical, medical complications noted 5.8%, 10.2%, 10.2% Supracricoid laryngectomies...
BACKGROUND: During the past decade, 18F-fluorocholine (FCH) PET/CT has been continuously performed at Tenon Hospital (Paris, France) for detection of hyperfunctioning parathyroid glands (PT).METHODS: A cohort 401 patients, deliberately referred HPT since September 2012, analyzed. The aim this real-life retrospective study was to determine diagnostic utility FCH in setting, overall and subgroups according type hyperparathyroidism (HPT), context imaging work-up patient's history: initial or...
A short abnormal polyalanine expansion in the polyadenylate-binding protein nuclear-1 (PABPN1) causes oculopharyngeal muscular dystrophy (OPMD). Mutated PABPN1 proteins accumulate as insoluble intranuclear aggregates muscles of OPMD patients. While roles nuclear polyadenylation and regulation alternative poly(A) site choice have been established, molecular mechanisms which trigger pathological defects role remain to be determined. Using exon array, for first time we identified several...
Thyroid calcification is frequent in thyroid nodules. The aim of our study was to evaluate the prevalence calcifications tissue samples patients with various diseases, and identify their composition according localization. Among 50 included, 56% were malignant (papillary carcinoma) 44% benign (adenoma, multinodular goiter, Graves' disease, sarcoidosis). Calcifications found 95% using polarised light microscopy, whereas only 12% described initial pathological reports. Three types...