A5025854394- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Insect symbiosis and bacterial influences
- Helminth infection and control
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- Evolution and Genetic Dynamics
- Plant Virus Research Studies
- Parasites and Host Interactions
- Insect Resistance and Genetics
- Parasite Biology and Host Interactions
- Insect-Plant Interactions and Control
- Vector-borne infectious diseases
- Biochemical and Molecular Research
- Toxoplasma gondii Research Studies
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Mosquito-borne diseases and control
- Race, Genetics, and Society
- French Urban and Social Studies
- Genetic diversity and population structure
- Lysosomal Storage Disorders Research
- Escherichia coli research studies
- Bacteriophages and microbial interactions
- Mycobacterium research and diagnosis
Institut de Recherche pour le Développement
2015-2025
Centre de Coopération Internationale en Recherche Agronomique pour le Développement
2025
Centre National de la Recherche Scientifique
2014-2024
Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle
2015-2024
Agropolis International
2001-2023
Université de Montpellier
1993-2019
Centre de Gestion Scientifique
1998-2014
University of California, Irvine
1993-2012
Institut de Recherche pour le Développement
2010-2011
Fondation Jean Dausset-CEPH
1997-2006
In an effort to unify the nomenclature of Trypanosoma cruzi, causative agent Chagas disease, updated system was agreed upon at Second Satellite Meeting.A consensus reached that T. cruzi strains should be referred by six discrete typing units (T.cruzi I-VI).The goal a unified is improve communication within scientific community involved in research.The justification and implications will presented subsequent detailed report.
We propose a general theory of clonal reproduction for parasitic protozoa, which has important medical and biological consequences. Many protozoa have been assumed to reproduce sexually, because diploidy occasional sexuality in the laboratory. However, population genetic analysis extensive data on biochemical polymorphisms indicates that two fundamental consequences sexual (i.e., segregation recombination) are apparently rare or absent natural populations protozoa. Moreover, clones recorded...
We have studied 15 gene loci coding for enzymes in 121 Trypanosoma cruzi stocks from a wide geographic range--from the United States and Mexico to Chile southern Brazil. T. is diploid but reproduction basically clonal, with very little if any sexuality remaining at present. identified 43 different clones by their genetic composition; same clone often found distant places diverse hosts. There much heterogeneity among clones, they cannot be readily classified into few discrete groups that...
We argue that the mode of reproduction microorganisms in nature can only be decided by population genetic information. The evidence available indicates many parasitic protozoa and unicellular fungi have clonal rather than sexual structures, which has major consequences for medical research practice. Plasmodium falciparum, agent malaria, is a special case: scarce contradictory, some suggesting uniparental lineages may exist nature. This puzzling (because P. falciparum known to stage) poses...
We have assayed genetic polymorphisms in several species of parasitic protozoa by means random amplified polymorphic DNA (RAPD). One goal was to ascertain the suitability RAPD markers for investigating and evolutionary problems, particularly organisms, such as protozoa, unsuitable traditional methods analysis. Another test certain hypotheses concerning Trypanosoma cruzi, other that been established multilocus enzyme electrophoresis. The results corroborate hypothesis population structure T....
A genetic interpretation of the zymograms 524 Trypanosoma cruzi stocks from various hosts and representing a broad geographical range (United States to Southern Brazil) reveals high variability (only one monomorphic locus out 15) suggests that this parasite has diploid structure. The data do not give any indication Mendelian sexuality, although many opportunities are present for exchange between extremely different genotypes. population structure T. appears be multiclonal complex. natural...
Randomly amplified polymorphic DNA (RAPD) analysis, multilocus enzyme electrophoresis (MLEE), and Southern blot hybridization with moderately repetitive probes have emerged as effective fingerprinting methods for the infectious fungus Candida albicans. The three been compared their capacities to identify identical or highly related isolates, cluster weakly discriminate between unrelated assess microevolution within a strain. By computing similarity coefficients 29 isolates from cities...
Summary Deciphering the structure of pathogen populations is instrumental for understanding epidemiology and history infectious diseases their control. Although Mycobacterium tuberculosis most widespread agent in humans, its actual population has remained hypothetical until now because: (i) structural genes are poorly polymorphic; (ii) adequate samples appropriate statistics genetic analysis have not been considered. To investigate this structure, we analysed statistical associations...
We propose that clonal evolution in micropathogens be defined as restrained recombination on an evolutionary scale, with genetic exchange scarce enough to not break the prevalent pattern of population structure, a definition already widely used for all kinds pathogens, although clearly formulated by many scientists and rejected others. The two main manifestations are strong linkage disequilibrium (LD) widespread clustering (“near-clading”). hypothesize this is mainly due natural selection,...
To ascertain the population structure of Candida albicans, we have carried out a multilocus enzyme electrophoresis study based on analysis 21 gene loci. We thus characterized 55 strains isolated one each from human immunodeficiency virus-positive patients. There is considerable polymorphism among strains. A population-genetic indicates that two fundamental consequences sexual reproduction (i.e., segregation and recombination) are apparently absent in this C. albicans. The albicans appears to...
A set of 434 Trypanosoma cruzi stocks from a wide ecogeographical range was analysed by Multilocus Enzyme Electrophoresis for 22 genetic loci. Strong linkage disequilibrium, not associated with geographical distance, and 2 main clusters each considerably heterogeneous, observed. These results support the hypotheses previously proposed that T. natural populations are composed highly diversified clones distributed into phylogenetic lineages: lineage 1, most ubiquitous in endemic area, more...