A5069410893- Vector-borne infectious diseases
- Autoimmune Bullous Skin Diseases
- Agriculture and Rural Development Research
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Polyomavirus and related diseases
- Autoimmune and Inflammatory Disorders
- African Botany and Ecology Studies
- Dermatological and Skeletal Disorders
- Urticaria and Related Conditions
- Inflammasome and immune disorders
- Cutaneous Melanoma Detection and Management
- melanin and skin pigmentation
- Eosinophilic Disorders and Syndromes
- Dermatological diseases and infestations
- Skin Diseases and Diabetes
- Melanoma and MAPK Pathways
- Bladder and Urothelial Cancer Treatments
- Dermatology and Skin Diseases
- Systemic Sclerosis and Related Diseases
- Allergic Rhinitis and Sensitization
- Autoimmune and Inflammatory Disorders Research
- Cutaneous lymphoproliferative disorders research
Université de Strasbourg
2016-2025
Hôpitaux Universitaires de Strasbourg
2014-2024
IQVIA (France)
2023
Hôpital Avicenne
2023
Hôpital Civil, Strasbourg
2011-2022
Centre Hospitalier Universitaire de Poitiers
2020
Centre National de la Recherche Scientifique
2019
Université Bourgogne Franche-Comté
2019
Centre Hospitalier Universitaire de Rouen
1991-2019
Université de Rouen Normandie
1991-2019
Abstract Acquired mutations in the UBA1 gene were recently identified patients with severe adult-onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic). However, precise physiological and clinical impact of these remains poorly defined. Here we study a unique prospective cohort patients. We show that monocytes from are quantitatively qualitatively impaired display features exhaustion aberrant expression chemokine receptors. In peripheral...
<b><i>Background:</i></b> The precise clinical description of skin lesions observed in some patients with hidradenitis suppurativa (HS) can be extremely difficult. <b><i>Objective:</i></b> Establishing a validated glossary terms allowing the best possible HS patients. <b><i>Material and Methods:</i></b> Five international experts were to assess series 25 photos representing typical this disorder. For each photo, asked...
The precise role of human epidermal Langerhans cells (LCs) in immune response is highly controversial. While studying the gene expression profile these cells, we were intrigued to identify HLA-DQB2 as potentially expressed LCs. Despite a strong evolutionary conservation their sequences, concomitant poorly polymorphic HLA-DQA2/HLA-DQB2 genes, paralogous HLA-DQA1/HLA-DQB1 has never been detected any cell type. We confirmed by RT-PCR that HLA-DQA2 and -DQB2 genes are both LCs, but not...
Blaschko-Linear Manifestations of Multifactorial Polygenic Diseases (BLMMPD) are rare. Their underlying pathogenesis is not known but genetic mosaicism supposed to be involved. To describe a series patients with BLMMPD and establish meaningful classification these manifestations. We retrospectively retrieved the records all Blaschko-linear lesions followed at our institution between 1994 2007. Only well-documented cases were included. 17 reviewed (11 men 6 women, mean age 42 years),...
Only about 30 cases of borrelial lymphocytoma (BL) with identification the causative species Borrelia have been published to date, mainly from Eastern or Central European countries.To identify B. burgdorferi complex responsible for BL in France.Nine patients acquired France and whom skin samples were sent national reference centre laboratory between 1994 2007 included this retrospective study. Direct detection was made by polymerase chain reaction targeting fla gene. Culture performed when...
Langerin is required for the biogenesis of Birbeck granules (BGs), characteristic organelles Langerhans cells. We previously used a Langerin-YFP fusion protein having C-terminal luminal YFP tag to dynamically decipher molecular and cellular processes which accompany traffic Langerin. In order elucidate interactions with its trafficking effectors their structural impact on BGs, we generated YFP-Langerin chimera an N-terminal, cytosolic tag. This latter induced formation YFP-positive large...
SUMMARY Acquired mutations in the UBA1 gene, occurring myeloid cells and resulting expression of a catalytically impaired isoform enzyme E1, were recently identified patients with severe adult-onset auto-inflammatory syndrome called VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic). The precise physiological clinical impact these remains poorly defined. Here, we studied unique prospective cohort individuals autoinflammatory disease (VEXAS) or without (VEXAS-like) somatic...
We recently recorded a high prevalence of inclusion body myositis (IBM) in patients with Sjögren's syndrome (SS). Whether SS differ from without terms the characteristics is currently unknown. Anti-cytosolic 5'-nucleotidase 1 A (cN1A) has been proposed as biomarker for IBM but also frequent SS. anti-cN1A independently associated still an open question. aimed to assess significance and patients.Cumulative data on all (EULAR/ACR 2017 criteria) screened (ACR/EULAR 2016 single centre were...
Introduction: Schnitzler's syndrome is a paradigm of an acquired autoinflammatory disorder, involving IL-1, which can now be pharmacologically targeted.Areas covered: Management covered in detail, by reviewing all published papers on this topic until May 2014. usually affects adult patients their fifties. The main symptoms are urticarial rash, fever, joint and/or bone pain, elevated CRP and leukocytosis patient with monoclonal IgM (or rarely IgG) gammopathy. It chronic/recurrent disorder...