Agathe Delbove
A5021735933- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Nosocomial Infections in ICU
- Family and Patient Care in Intensive Care Units
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- Injury Epidemiology and Prevention
- Thermal Regulation in Medicine
- Transplantation: Methods and Outcomes
- Emergency and Acute Care Studies
- Airway Management and Intubation Techniques
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Trauma and Emergency Care Studies
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Lung Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Polyomavirus and related diseases
- Neuroscience of respiration and sleep
- Nutrition and Health in Aging
- Venous Thromboembolism Diagnosis and Management
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Centre hospitalier Bretagne Atlantique
2020-2025
Hôpital Saint-Louis
2024
Assistance Publique – Hôpitaux de Paris
2024
Centre Hospitalier Universitaire de Nantes
2015-2022
Inserm
2022
Centre Hospitalier Universitaire de Rennes
2022
Université de Poitiers
2022
Institut du Thorax
2015-2022
Nantes Université
2020
Bicêtre Hospital
2015
Importance The benefit of high-flow nasal cannula oxygen (high-flow oxygen) in terms intubation and mortality patients with respiratory failure due to COVID-19 is controversial. Objective To determine whether the use oxygen, compared standard could reduce rate at day 28 admitted intensive care units (ICUs). Design, Setting, Participants SOHO-COVID randomized clinical trial was conducted 34 ICUs France included 711 a ratio partial pressure arterial fraction inspired equal or below 200 mm Hg....
Spontaneous-breathing trials can be performed with the use of either pressure-support ventilation (PSV) or a T-piece. Whether PSV may result in shorter time to tracheal extubation than T-piece trials, without resulting higher risk reintubation, among patients who have high failure is unknown.In this multicenter, open-label trial, we randomly assigned had (i.e., were >65 years age an underlying chronic cardiac respiratory disease) undergo spontaneous-breathing (with level 8 cm water and no...
Abstract Rationale Early corticosteroid treatment is used to treat COVID-19-related acute respiratory distress syndrome (ARDS). Infection a well-documented adverse effect of therapy. Objectives To determine whether early therapy COVID-19 ARDS was associated with ventilator-associated pneumonia (VAP). Methods We retrospectively included adults COVID-19-ARDS requiring invasive mechanical ventilation (MV) for ≥ 48 h at any 15 intensive care units in 2020. divided the patients into two groups...
No recommendation exists about the timing and setting for tracheal intubation mechanical ventilation in septic shock.This prospective multicenter observational study was conducted 30 ICUs France Spain. All consecutive patients presenting with shock were eligible. The use of described across participating ICUs. A multivariate analysis performed to identify parameters associated early (before H8 following vasopressor onset).Eight hundred fifty-nine enrolled. Two nine intubated (24%, range...
Abstract Background Delaying time to prone positioning (PP) may be associated with higher mortality in acute respiratory distress syndrome (ARDS) due coronavirus disease 2019 (COVID-19). We evaluated the use and impact of early PP on clinical outcomes intubated patients hospitalized intensive care units (ICUs) for COVID-19. Methods All ARDS COVID-19 were involved a secondary analysis from prospective multicenter cohort study COVID-ICU network including 149 ICUs across France, Belgium...
Abstract Background Prevalence, risk factors and medical management of persistent pain symptoms after critical care illness have not been thoroughly investigated. Methods We performed a prospective multicentric study in patients with an intensive unit (ICU) length stay ≥ 48 h. The primary outcome was the prevalence significant pain, defined as numeric rating scale (NRS) 3, 3 months admission. Secondary outcomes were compatible neuropathic (ID-pain score > 3) pain. Results Eight hundred...
Abstract Background We aimed to evaluate the cardiac adverse events (AEs) in hospitalized patients with coronavirus disease 2019 (COVID-19) who received remdesivir plus standard of care (SoC) compared SoC alone (control), as an association was noted some cohort studies and disproportionality analyses safety databases. Methods This post hoc analysis is based on data from multicenter, randomized, open-label, controlled DisCoVeRy trial COVID-19. Any first AE that occurred between randomization...
Antistaphylococcal penicillin (ASP) is the first-line therapy for MSSA bloodstream infection (BSI), with cefazolin as an alternative. However, ASPs are associated a high risk of acute kidney injury (AKI) and overexposure. We implemented kidney-sparing protocol based on: (i) systematic use in patients creatinine clearance <60 mL/min or any factor AKI; (ii) reduced ASP dose (75-100 mg/kg/day) therapeutic drug monitoring. compared all episodes BSI adults admitted during 15 months before...
Introduction Out-of-hospital cardiac arrest is a public health concern with high mortality rate. Hypoxic ischaemic brain injury the primary cause of death in patients admitted to intensive care unit (ICU) after return spontaneous circulation (ROSC). Several systemic factors, such as hypotension, can exacerbate injuries. International guidelines recommend targeting mean arterial pressure (MAP) at least 65 mm Hg. observational studies suggest that higher MAP may be associated better outcomes,...
Abstract Background Ventilator-associated pneumonia (VAP) is a prevalent nosocomial infection in intensive care units (ICUs) with significant impacts on patient outcomes and healthcare costs. Multiplex PCR could allow for personalized empirical treatment of VAP optimize antibiotic therapy. Methods This multicenter retrospective study analyzed culture-positive cases from January 2016 to March 2021 across 12 ICUs France. The prevalence non-targeted bacteria was evaluated according the...
Limitations of life-sustaining therapies (LST) practices are frequent and vary among intensive care units (ICUs). However, scarce data were available during the COVID-19 pandemic when ICUs under intense pressure. We aimed to investigate prevalence, cumulative incidence, timing, modalities, factors associated with LST decisions in critically ill patients. did an ancillary analysis European multicentre COVID-ICU study, which collected from 163 France, Belgium Switzerland. ICU load, a parameter...
Abstract Background Recent studies identified coronavirus disease 2019 (COVID-19) as a risk factor for invasive pulmonary aspergillosis (IPA) but produced conflicting data on IPA incidence and impact patient outcomes. We aimed to determine the outcomes of COVID-19-associated (CAPA) in mechanically ventilated patients. Methods performed multicenter retrospective observational cohort study consecutive adults admitted 15 French intensive care units (ICUs) 2020 COVID-19 requiring mechanical...
Abstract Background Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience its associations with PTSD quality of life, also identified factors associated greater resilience. Methods This prospective, multicentre, study in patients recruited at 41 French ICUs was done parallel the NUTRIREA-3 trial given...
Backgrounds: High flow nasal cannula (HFNC) is an alternative therapy for acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19). This study aimed first describe outcomes of patients suffering from COVID-19-related ARDS treated with HFNC; secondly evaluate safety HFNC (patients and healthcare workers) compare according outcome. Methods: A retrospective cohort was conducted in French general hospital intensive care unit (ICU). Patients were included if receiving...
Abstract Background Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly related to Enterobacterales. Data regarding extended-spectrum beta-lactamase producing Enterobacterales (ESBL-E) VAP are scarce. We aimed investigate risk factors outcomes ESBL-E among critically ill infectious disease-19 (COVID-19) patients who developed VAP. methods...
Abstract Background Predicting outcomes of critically ill intensive care unit (ICU) patients with coronavirus-19 disease (COVID-19) is a major challenge to avoid futile, and prolonged ICU stays. Methods The objective was develop predictive survival models for COVID-19 after 1-to-2 weeks in ICU. Based on the COVID–ICU cohort, which prospectively collected characteristics, management, COVID-19. Machine learning used dynamic, clinically useful able predict 90-day mortality using data day (D) 1,...
Among strategies that aimed to prevent acquired infections (AIs), selective decontamination regimens have been poorly studied in the COVID-19 setting. We assessed impact of a multiple-site (MSD) regimen on incidence bloodstream (BSI) and ventilator-associated pneumonia (VAP) patients receiving mechanical ventilation.We performed an ancillary analysis multicenter retrospective observational study 15 ICUs western France. In addition standard-care (SC), 3 used MSD, variant digestive...
Abstract Purpose Despite the benefits of mechanical ventilation, its use in critically ill patients is associated with complications and had led to growth noninvasive techniques. We assessed effect early intubation (first 8 h after vasopressor start) septic shock patients, as compared non-early intubated subjects (unexposed), regarding in-hospital mortality, intensive care hospital length stay. Methods This study involves secondary analysis a multicenter prospective study. To adjust for...