Carlos Ferrando
A5083694677- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- Airway Management and Intubation Techniques
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Hemodynamic Monitoring and Therapy
- Thermal Regulation in Medicine
- Anesthesia and Sedative Agents
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Family and Patient Care in Intensive Care Units
- Ultrasound in Clinical Applications
- COVID-19 and healthcare impacts
- Mechanical Circulatory Support Devices
- Nosocomial Infections in ICU
- Non-Invasive Vital Sign Monitoring
- Antifungal resistance and susceptibility
- Enhanced Recovery After Surgery
- Anesthesia and Pain Management
- Tracheal and airway disorders
- Cardiac electrophysiology and arrhythmias
- Pleural and Pulmonary Diseases
Instituto de Salud Carlos III
2017-2025
Centro de Investigación Biomédica en Red
2019-2025
Hospital Clínic de Barcelona
2019-2025
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2019-2025
Universitat de Barcelona
2019-2024
Centro de Investigación Biomédica en Red de Enfermedades Respiratorias
2020-2024
Hospital Israelita Albert Einstein
2024
Monash University
2024
Austin Hospital
2024
Instituto Maimónides de Investigación Biomédica de Córdoba
2021-2024
The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe outcomes confirmed in COVID-19 managed invasive mechanical (MV).
<h3>Importance</h3> Enhanced Recovery After Surgery (ERAS) care has been reported to be associated with improvements in outcomes after colorectal surgery compared traditional care. <h3>Objective</h3> To determine the association between ERAS protocols and patients undergoing elective surgery. <h3>Design, Setting, Participants</h3> The Postoperative Outcomes Within Protocol (POWER) Study is a multicenter, prospective cohort study of 2084 consecutive adults scheduled for who received or did...
Objective: The open lung approach is a mechanical ventilation strategy involving recruitment and decremental positive end-expiratory pressure trial. We compared the Acute Respiratory Distress Syndrome network protocol using low levels of with resulting in moderate to high for management established moderate/severe acute respiratory distress syndrome. Design: A prospective, multicenter, pilot, randomized controlled Setting: 20 multidisciplinary ICUs. Patients: Patients meeting...
Whether the use of high-flow nasal oxygen in adult patients with COVID-19 associated acute respiratory failure improves clinically relevant outcomes remains unclear. We thus sought to assess effect on ventilator-free days, compared early initiation invasive mechanical ventilation, COVID-19.We conducted a multicentre cohort study using prospectively collected database admitted 36 Spanish and Andorran intensive care units (ICUs). Main exposure was (conservative group), while ventilation...
Abstract Background Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether combination high-flow nasal oxygen therapy (HFNO) with awake-PP prevents need for intubation when compared HFNO alone. Methods Prospective, multicenter, adjusted observational cohort study consecutive COVID-19 acute respiratory failure (ARF)...
BACKGROUND: We investigated whether individualized positive end-expiratory pressure (PEEP) improves oxygenation, ventilation, and lung mechanics during one-lung ventilation compared with standardized PEEP. METHODS: Thirty patients undergoing thoracic surgery were randomly allocated to the study or control group. Both groups received an alveolar recruitment maneuver at beginning end of ventilation. After maneuver, group had their lungs ventilated a 5 cm·H2O PEEP, while PEEP level determined...
The driving pressure (plateau minus positive end-expiratory pressure) has been suggested as the major determinant for beneficial effects of lung-protective ventilation. We tested whether was superior to variables that define it in predicting outcome patients with acute respiratory distress syndrome.A secondary analysis existing data from previously reported observational studies.A network ICUs.We studied 778 moderate severe syndrome.None.We assessed risk hospital death based on quantiles...
COVID-19 coagulopathy linked to increased D-dimer levels has been associated with high mortality (Fei Z et al. in Clinical course and risk factors for of adult inpatients Wuhan, China: a retrospective cohort study. Lancet (London, England) 395(10229):1054–62, 2020). While is accepted as disseminated intravascular coagulation marker, rotational thromboelastometry (ROTEM) also detects fibrinolysis (Wright FL Fibrinolysis shutdown correlates thromboembolic events severe infection. J Am Coll...
Abstract Background Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose. Methods This is nationwide, prospective, multicenter, observational, cohort study in critically adult COVID-19 admitted into Intensive Care Units (ICU) Spain from 12th March 29th June 2020. Using...
Although there is general agreement on the characteristic features of acute respiratory distress syndrome, we lack a scoring system that predicts syndrome outcome with high probability. Our objective was to develop an score clinicians could easily calculate at bedside predict risk death patients 24 hours after diagnosis.A prospective, multicenter, observational, descriptive, and validation study.A network multidisciplinary ICUs.Six-hundred meeting Berlin criteria for moderate severe enrolled...
We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated a shift invasive mechanical ventilation.This is multicenter, observational study from prospectively collected database consecutive admitted 36 Spanish Andorran intensive care units (ICUs) who received HFNO on ICU admission during 22-week period (March 12-August 13, 2020). Outcomes interest were day need for endotracheal intubation. used multivariable...
Abstract Background There are no specific generally accepted therapies for the coronavirus disease 2019 (COVID-19). The full spectrum of COVID-19 ranges from asymptomatic to mild respiratory tract illness severe pneumonia, acute distress syndrome (ARDS), multisystem organ failure, and death. efficacy corticosteroids in viral ARDS remains unknown. We postulated that adjunctive treatment established caused by with intravenous dexamethasone might change pulmonary systemic inflammatory response...
The primary aim of our study was to investigate the association between intubation timing and hospital mortality in critically ill patients with coronavirus disease 2019 (COVID-19)-associated respiratory failure. We also analysed both impact such throughout first four pandemic waves influence prior noninvasive support on outcomes.This is a secondary analysis multicentre, observational prospective cohort that included all consecutive undergoing invasive mechanical ventilation due COVID-19...
OBJECTIVES: To assess the value of machine learning approaches in development a multivariable model for early prediction ICU death patients with acute respiratory distress syndrome (ARDS). DESIGN: A development, testing, and external validation study using clinical data from four prospective, multicenter, observational cohorts. SETTING: network multidisciplinary ICUs. PATIENTS: total 1,303 moderate-to-severe ARDS managed lung-protective ventilation. INTERVENTIONS: None. MEASUREMENTS AND MAIN...
Acute respiratory distress syndrome is characterised by activation of the inflammatory cascade. The only treatment that reduces mortality rate associated with this lung protective ventilation, which requires sedation patients. Sedation in critical care units usually induced intravenously, although there reason to believe inhaled anaesthetics are a suitable alternative. Sevoflurane has recently been shown modulate response model injury more favourably than propofol.The goal study was confirm...
Background Low tidal volume (VT) during anesthesia minimizes lung injury but may be associated to a decrease in functional impairing mechanics and efficiency. Lung recruitment (RM) can restore this critically depend on the post-RM selected PEEP. This study was randomized, two parallel arm, open whose primary outcome compare effects driving pressure of adding RM low-VT ventilation, with or without an individualized PEEP patients known previous disease anesthesia. Methods Consecutive scheduled...