A5001815508- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Magnetism in coordination complexes
- Metal complexes synthesis and properties
- Metal-Catalyzed Oxygenation Mechanisms
- Lanthanide and Transition Metal Complexes
- Airway Management and Intubation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Metal-Organic Frameworks: Synthesis and Applications
- Anesthesia and Pain Management
- Crystallography and molecular interactions
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Head and Neck Surgical Oncology
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Sedative Agents
- Cerebrospinal fluid and hydrocephalus
- Organic and Molecular Conductors Research
- Intensive Care Unit Cognitive Disorders
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neurosurgical Procedures and Complications
- Obstructive Sleep Apnea Research
- Meningioma and schwannoma management
- Simulation-Based Education in Healthcare
- Thermal Regulation in Medicine
Universitat de Barcelona
2012-2025
Hospital Clínic de Barcelona
2010-2025
Neurological Surgery
2023
Centro de Investigación Biomédica en Red de Salud Mental
2020
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020
Universitat Autònoma de Barcelona
2020
Hospital Universitari i Politècnic La Fe
2020
Hospital Universitario de La Princesa
2020
Complejo Hospitalario de Pontevedra
2020
Hospital Clínico Universitario de Valencia
2020
The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe outcomes confirmed in COVID-19 managed invasive mechanical (MV).
Abstract Background Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether combination high-flow nasal oxygen therapy (HFNO) with awake-PP prevents need for intubation when compared HFNO alone. Methods Prospective, multicenter, adjusted observational cohort study consecutive COVID-19 acute respiratory failure (ARF)...
Abstract Background Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose. Methods This is nationwide, prospective, multicenter, observational, cohort study in critically adult COVID-19 admitted into Intensive Care Units (ICU) Spain from 12th March 29th June 2020. Using...
A study of the magnetostructural correlations in polynuclear complexes containing a Cu4O4 cubane structure has been carried out employing theoretical calculations based on Density Functional Theory. We have analyzed independently magnetic properties three different families complexes, classified according to number short and long Cu⋯Cu distances as 2 + 4, 4 or 6 0. The results indicate that coupling through four Cu–O bridges can be from weakly ferromagnetic strongly antiferromagnetic, while...
Abstract A dinuclear Ni II complex, [Ni 2 ( L ) (H O)(NCS) ] · 3H O 1 in which the metal atoms are bridged by one water molecule and two μ ‐phenolate ions, a thiocyanato‐bridged dimeric Cu [Cu( )NCS] [ = tridentate Schiff‐base ligand, N ‐(3‐aminopropyl)salicylaldimine, derived from 1:1 condensation of salicylaldehyde 1,3‐diaminopropane], have been synthesized characterized IR UV/Vis spectroscopy, cyclic voltammetry single‐crystal X‐ray diffraction studies. The structure consists units with...
Theoretical methods based on density-functional theory with Gaussian, plane waves, and numerical basis sets were employed to evaluate the exchange coupling constants in transition-metal complexes. In case of set, effect different computational parameters was tested. We analyzed whether how use pseudopotentials affects calculation constants. For three sets, a comparison spin distributions shows that both plane-wave set approaches are accurate reliable alternatives more established Gaussian functions.
High-spin molecules have been proposed as candidates for the storage of information at molecular level. The electronic structure two complex magnetic systems, Mn10 and Mn19, is characterized by means a computational study based on density functional theory. All exchange interactions in recently reported Mn19 with highest known spin value 83/2, its highly symmetric parent compound, are ferromagnetic. In these complexes, there kinds ferromagnetic coupling: first one corresponds to MnII−MnIII...
Two new CuII linear trinuclear Schiff base complexes, [Cu3(L)2(CH3COO)2] (1) and [Cu3(L)2(CF3COO)2] (2), have been prepared using a symmetrical ligand H2L [where = N,N′-bis(2-hydroxyacetophenone)propylenediimine]. Both of the complexes characterized by elemental analyses, Fourier transform IR, UV/vis, electron paramagnetic resonance spectroscopy. Single-crystal X-ray structures show that adjacent ions are linked double phenoxo bridges μ2−η1:η1 carboxylato bridge. In each complex, central...
The new tetranuclear carbonate complex [Cu2L)2(CO3)]·8H2O (1·8H2O) (H3L = (2-(2-hydroxyphenyl)-1,3-bis[4-(2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine) has been obtained by two different synthetic routes and fully characterized. Recrystallization of 1·8H2O in methanol yields single crystals {[(Cu2L)2(CO3)]}2·12H2O (1·6H2O), suitable for X-ray diffraction studies. crystal structure 1·6H2O shows crystallographically molecules the asymmetric unit, 1a 1b. Both can be understood as...
Abstract A new tetranuclear complex, [Cu 4 L ] · 2H 2 O ( 1 ), has been synthesized from the self‐assembly of copper(II) perchlorate and tridentate Schiff base ligand 4‐chloro‐2‐[( E )‐(2‐hydroxyethylimino)methyl]phenol (H L). Single‐crystal X‐ray diffraction studies reveal that complex consists a Cu cubane core where four centers are linked by μ 3 ‐alkoxo bridges. Each II ion assumes distorted square‐pyramidal geometry with CuNO chromophore. Variable‐temperature magnetic susceptibility data...
Supplemental magnesium sulfate has a potential neuroprotective role in acute brain injury. It is safe, widely available, and inexpensive. This study evaluated the effect of perioperative intravenous administration on damage caused by neurosurgery. Prospective randomized double-blind controlled study. Fifty adult patients undergoing supratentorial neurosurgery (25 were assigned to group 26 control group). On arrival operating room, intervention received sulfate, 4 g bolus 100 mL 0.9% saline...
Deep brain stimulation has become the standard of care for refractory Parkinson's disease. Neuroimaging advances have led to image-based targeting subthalamic nucleus under general anaesthesia (GA), an approach that renders unnecessary microelectrode recording and tests local conscious sedation (CS). We aimed compare procedures incidents related each anaesthetic approach. Retrospective descriptive comparison deep CS versus G. collected patient procedure data (e.g., comorbidities, difficult...
The endoscopic superior eyelid approach is a relatively novel mini-invasive technique that currently investigating for skull base cancers. However, questions remain regarding specific approach-related complications when treating different tumors. This study aims to analyze any surgical occurred in our preliminary consecutive experience, with focus on orbital outcome.
The reaction of ethanolic/water solutions NiX2·6H2O (X = NO3-, ClO4-), bidentate amine N,N,N',N'-tetramethylethylenediamine (tmen) and N,N,N'-trimethylethylenediamine (trimen) with [Cu(oxpn)] (oxpn N,N'-bis(3-aminopropyloxamide) ammonium thiocyanate, in the presence hexafluorophosphate when X is leads to high-yield formation new heterotetranuclear (Cu−Ni)2 complexes general formulation [Cu(oxpn)Ni(μ-NCS)(H2O)(aa)]2(X)2 (1, PF6-, aa tmen; 2, ClO4-, 3, ClO4-; trimen; 4 , trimen). crystal...
A pyrazole based ditopic ligand (PzOAP), prepared by the reaction between 5-methylpyrazole-3-carbohydrazide and methyl ester of imino picolinic acid, reacts with Cu(NO3)2·6H2O to form a self-assembled, ferromagnetically coupled, alkoxide bridged tetranuclear homoleptic Cu(II) square grid-complex [Cu4(PzOAP)4(NO3)2] (NO3)2·4H2O (1) central Cu4[µ-O4] core, involving four molecules. In out copper centers, two centers are penta-coordinated remaining hexa-coordinated. each case hexa-coordination,...
Four new supramolecular compounds of Cu(II)-Ni(II) have been synthesized and characterized: [Cu(Me(2)oxpn)Ni(mu-NCS)(H(2)O)(tmen)](2)(ClO(4))(2) (1), [Cu(Me(2)oxpn)Ni(mu-NCS)(H(2)O)(tmen)](2)(PF(6))(2) (2), [Cu(oxpn)Ni(mu-NCS)(NCS) (tmen)](n) (3), [Cu(Me(2)oxpn)Ni(mu-NCS)(NCS)(tmen)](n) (4), where oxpn = N,N'-bis(3-aminopropyl)oxamidate, Me(2)oxpn N,N'-bis(3-amino-2,2'-dimethylpropyl)oxamidate, tmen N,N,N',N'-tetramethylethylenediamine. Their crystal structures were solved. Complexes 1 2 the...
Three oxamato-bridged copper(II) complexes of formula [{Cu(H2O)(tmen)Cu(tmen)}{μ-Cu(H2O)(Me2pba)}]n{(PF6)2}n·2nH2O (1), [{Cu(H2O)(tmen)Cu(NCS)(tmen)}{μ-Cu(H2O)(Me2pba)}]2(ClO4)2·4H2O (2), and [{Cu(H2O)(tmen)Cu(NCS)(tmen)}{μ-Cu(H2O)(Me2pba)}]2(PF6)2·4H2O (3), where Me2pba = 2,2-dimethyl-1,3-propylenebis(oxamato) tmen N,N,N‘,N‘-tetramethylethylenediamine, have been synthesized characterized. Their crystal structures were solved. Complex 1 crystallizes in the monoclinic system, space group P21,...
In cirrhotic patients undergoing hepatic surgery, postoperative analgesia remains a challenge. this study, we evaluated the efficacy of single dose morphine combined with small-dose ketamine given epidurally for pain relief. One-hundred-four classification “Child A” were randomly assigned to two groups: 1) (MKG, n = 54): epidural (3.5–5 mg) plus (20/30 mg); and 2) (3.5/5 (MG, 50). The level analgesia, side effects, psychomimetic neurological disorders, additional analgesic needs, overall...
Intermittent high peak pressure values inside the endoscope during neuroendoscopic surgical procedures are associated with postoperative morbidity. Unexpected delay in awakening is complication most frequently observed by anesthesiologist as a result of endoscope. During eight authors continuously monitored cerebral hemodynamic function, using transcranial doppler (TCD) probe fixed on patients' temporal window. We that episodes navigation rinsing periods resulted changes TCD wave profile...
In Brief Airway management in patients with penetrating neck trauma must guarantee cervical spine stability. Moreover, the prone position increases risk of difficult ventilation and injury. A 19-yr-old patient was brought to emergency room a drill bit protruding from posterolateral aspect his neck. The had entered spinal canal below first vertebra, placed near odontoid peg. He referred for surgical removal drill. use an inhaled induction anesthesia, avoiding muscle relaxants, through...
The paper reports the synthesis, X-ray and neutron diffraction crystal structures, magnetic properties, high field-high frequency EPR (HF-EPR), spin density theoretical description of tetranuclear CuII complex [Cu4L4] with cubane-like structure (LH2=1,1,1-trifluoro-7-hydroxy-4-methyl-5-aza-hept-3-en-2-one). simulation behavior gives a predominant ferromagnetic interaction J1 (+30.5 cm(-1)) weak antiferromagnetic J2 (-5.5 cm(-1)), which correspond to short long Cu-Cu distances, respectively,...
The simple nickel(II) acetate/H(3)L system (H(3)L = 2-(2-hydroxyphenyl)-1,3-bis[4-(2-hydroxyphenyl)-3-azabut-3-enyl]-1,3-imidazolidine) presents an unusually complicated reactivity scheme, which strongly depends on the Ni(OAc)(2)/H(3)L molar ratio and pH of medium. Thus, in addition to formerly reported compounds [Ni(2)L(OAc)(H(2)O)(2)][Ni(2)L(OAc)(H(2)O)(HOAc)].3.25H(2)O, 1.3.25H(2)O; [{Ni(3)L(OAc)(OH)(H(2)O)(MeOH)(2)}(CO(3)){Ni(2)L(OAc)(MeOH)(2)}].2.7H(2)O.1.5MeOH, 2.2.7H(2)O.1.5MeOH;...
In cirrhotic patients undergoing hepatic surgery, postoperative analgesia remains a challenge. this study, we evaluated the efficacy of single dose morphine combined with small-dose ketamine given epidurally for pain relief. One-hundred-four classification "Child A" were randomly assigned to two groups: 1) (MKG, n = 54): epidural (3.5–5 mg) plus (20/30 mg); and 2) (3.5/5 (MG, 50). The level analgesia, side effects, psychomimetic neurological disorders, additional analgesic needs, overall...
The pyrazole derived Schiff base polytopic ligand 5-methyl-N′-[1-(pyridin-2-yl)ethylidene]-1H-pyrazole-3-carbohydrazide (PzCAP), prepared by the reaction between 5-methylpyrazole-3-carbohydrazide and 2-acetyl pyridine, has two potentially bridging functional groups [μ-O μ-(N-N)] consequently can exhibit different coordination conformations. Two tetranuclear homoleptic copper(II) 2 × rectangular grid-complexes [Cu4(PzCAP)4(NO3)2] (NO3)2·8H2O (1) [Cu4(PzCAP)4(ClO4)2] (ClO4)2 (2) were formed a...