A5072909652- Hemodynamic Monitoring and Therapy
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Respiratory Support and Mechanisms
- Ultrasound in Clinical Applications
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Renal function and acid-base balance
- Airway Management and Intubation Techniques
- Artificial Intelligence in Healthcare and Education
- Mechanical Circulatory Support Devices
- Machine Learning in Healthcare
- Adrenal Hormones and Disorders
- Optical Imaging and Spectroscopy Techniques
- Anesthesia and Neurotoxicity Research
- Cardiac Valve Diseases and Treatments
- Tracheal and airway disorders
- Cardiac Imaging and Diagnostics
- Thermal Regulation in Medicine
- Obstructive Sleep Apnea Research
- Mobile Health and mHealth Applications
- Nausea and vomiting management
- Statistical Methods in Epidemiology
Hospital Clínic de Barcelona
2015-2024
Harvard University
2024
Harvard–MIT Division of Health Sciences and Technology
2022-2023
Massachusetts Institute of Technology
2023
Universitat de Barcelona
2006-2023
Computational Physics (United States)
2022
Hospital Universitari i Politècnic La Fe
2020
Hospital Universitario de La Princesa
2020
Complejo Hospitalario de Pontevedra
2020
Hospital Clínico Universitario de Valencia
2020
The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe outcomes confirmed in COVID-19 managed invasive mechanical (MV).
Abstract Background Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether combination high-flow nasal oxygen therapy (HFNO) with awake-PP prevents need for intubation when compared HFNO alone. Methods Prospective, multicenter, adjusted observational cohort study consecutive COVID-19 acute respiratory failure (ARF)...
Sharing healthcare data is increasingly essential for developing data-driven improvements in patient care at the Intensive Care Unit (ICU). However, it also very challenging under strict privacy legislation of European Union (EU). Therefore, we explored four successful open ICU databases to determine how can be shared appropriately EU. A questionnaire was constructed based on Delphi method. Then, follow-up questions were discussed with experts from databases. These encountered similar...
Abstract Background Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose. Methods This is nationwide, prospective, multicenter, observational, cohort study in critically adult COVID-19 admitted into Intensive Care Units (ICU) Spain from 12th March 29th June 2020. Using...
We present the INSPIRE dataset, a publicly available research dataset in perioperative medicine, which includes approximately 130,000 surgical operations at an academic institution South Korea over ten-year period between 2011 and 2020. This comprehensive patient characteristics such as age, sex, American Society of Anesthesiologists physical status classification, diagnosis, procedure code, department, type anaesthesia. The also vital signs operating theatre, general wards, intensive care...
Abstract We validated a Deep Embedded Clustering (DEC) model and its adaptation for integrating mixed datatypes (in this study, numerical categorical variables). is promising technique capable of managing extensive sets variables non-linear relationships. Nevertheless, DEC cannot adequately handle datatypes. Therefore, we adapted by replacing the autoencoder with an X-shaped variational (XVAE) optimising hyperparameters cluster stability. call “X-DEC”. compared X-DEC reproducing previous...
In Brief BACKGROUND: The increasing demand for anesthetic procedures in the gastrointestinal endoscopy area has not been followed by a similar increase methods to provide and control sedation analgesia these patients. this study, we evaluated different combinations of propofol remifentanil, administered through target-controlled infusion system, estimate optimal concentrations as well best way sedative effects induced drugs patients undergoing ultrasonographic endoscopy. METHODS: One hundred...
The purpose of this study was to identify optimal target propofol and remifentanil concentrations avoid a gag reflex in response insertion an upper gastrointestinal endoscope.Patients presenting for endoscopy received target-controlled infusions (TCI) both sedation-analgesia. Patients were randomized 4 groups fixed effect-site concentrations: 1 ng•mL (REMI 1) or 2 2) μg•mL (PROP 3 3). For each group, the other drug (propofol REMI vice versa) increased decreased using "up-down" method based...
Objective Evaluation of the ratio oxyhaemoglobin to total haemoglobin in skeletal muscle (StO 2 ) using near-infrared spectroscopy may aid monitoring patients with sepsis. This study assessed benefits and risks targeting StO adults severe sepsis or septic shock. Design A European randomised controlled trial was performed on two parallel groups. Setting Five intensive care units (ICU) France, Greece, Spain Germany were used for study. Participants 103 shock ICU admission (54 subjects...
Respiratory depression is a common adverse effect of propofol and remifentanil. We aimed to develop model for respiratory depressant effects with remifentanil in patients undergoing endoscopy sedation. Data were available 136 Participants randomly received infusions Predicted plasma concentrations, outputted by infusion pumps, available. Transcutaneous arterial pressure carbon dioxide (pCO<sub>2</sub>) was measured. analyzed using nonlinear mixed-effects modeling methods. Covariate...
Echocardiography has gained wide acceptance among intensive care physicians during the last 15 years. The lack of accredited formation, long learning curve required and excessive structural orientation present algorithms to evaluate hemodynamically unstable patients hampers its daily use in unit. aim this article is show 4 cases where our simple algorithm based on VTI, was crucial. Subsequently, explain benefit using proposed with a more functional perspective, as means for clinical...
Abstract Background: The presence of the A118G single nucleotide polymorphism in OPRM1 gene as well noxious stimulation might affect requirements remifentanil for patients undergoing ultrasonographic endoscopy under sedation-analgesia with propofol and remifentanil. Bispectral index (BIS) was used a surrogate measure effect. Methods: A total 207 were screened randomly received different combinations remifentanil, changed depending on nausea response to tube introduction. Nonlinear mixed...
The level of sedation in patients undergoing medical procedures evolves continuously, affected by the interaction between effect anesthetic and analgesic agents pain stimuli. monitors depth anesthesia, based on analysis electroencephalogram (EEG), have been progressively introduced into daily practice to provide additional information about state patient. However, quantification analgesia still remains an open problem. purpose this work is improve prediction nociceptive responses with linear...
Abstract Purpose Invasive ventilation is a fundamental treatment in intensive care but its precise timing difficult to determine. This study aims at assessing the effect of initiating invasive versus waiting, patients with hypoxemic respiratory failure without immediate reason for intubation on one-year mortality. Methods Emulation target trial estimate benefit immediately failure, among within first 48-h hypoxemia. The eligible population included non-intubated SpO 2 /FiO ≤ 200 and 97%. was...
In Brief The LMA-CTrach™ combines the features of Intubating Laryngeal Mask Airway™ with a fiberoptic system and screen for visualization airway. Local pathology, such as lingual tonsillar hyperplasia, may obstruct view airway leading to unanticipated difficult intubation. We present two cases failed intubation LMA-CTrach in patients hyperplasia. both cases, maintained adequate ventilation, giving time prepare alternative strategies. IMPLICATIONS: LMA CTrach™ is new management device viewer...
To investigate the effect of endothelin receptor A (ET(A)) and B (ET(B)) blockade on liver microcirculation oxygenation during intra-abdominal pressure (IAP) increase.Fifteen anesthetized pigs were randomized to receive either nonselective endothelin-1 (ET-1) blocker tezosentan (TG, n = 7) or saline (CG, 8). Helium was insufflated increase IAP from 0 25 mmHg. Stroke volume variability maintained ≤ 12% with colloid infusion. Total blood flow (TLBF), hepatic microcirculatory (MBF), tissue...