A5041225333- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- COVID-19 and healthcare impacts
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Thermal Regulation in Medicine
- Pediatric Pain Management Techniques
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Blood properties and coagulation
- Dermatological and COVID-19 studies
- Adrenal Hormones and Disorders
- Aortic Disease and Treatment Approaches
- Congenital Heart Disease Studies
- Vitamin K Research Studies
- Nausea and vomiting management
- Hemoglobinopathies and Related Disorders
- Venous Thromboembolism Diagnosis and Management
- Clinical Nutrition and Gastroenterology
- Health and Medical Education
- Neurogenetic and Muscular Disorders Research
Universitat de Barcelona
2018-2024
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2020-2024
Hospital Clínic de Barcelona
2020-2024
Fundació Clínic per a la Recerca Biomèdica
2024
National Institute on Aging
2020
Uniformed Services University of the Health Sciences
2020
National Institute of Neurological Disorders and Stroke
2020
Hospital Clínico Universitario de Valencia
2020
Hospital Universitario de La Princesa
2020
Complejo Hospitalario de Pontevedra
2020
The main characteristics of mechanically ventilated ARDS patients affected with COVID-19, and the adherence to lung-protective ventilation strategies are not well known. We describe outcomes confirmed in COVID-19 managed invasive mechanical (MV).
Abstract Background Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether combination high-flow nasal oxygen therapy (HFNO) with awake-PP prevents need for intubation when compared HFNO alone. Methods Prospective, multicenter, adjusted observational cohort study consecutive COVID-19 acute respiratory failure (ARF)...
COVID-19 is associated with a substantial risk of venous thrombotic events, even in the presence adequate thromboprophylactic therapy.We aimed to better characterize hypercoagulable state patients receiving anticoagulant took plasma samples 23 who were on prophylactic or intensified therapy. Twenty healthy volunteers included establish reference ranges.COVID-19 had mildly prolonged prothrombin time, high von Willebrand factor levels and low ADAMTS13 activity. Most rotational...
Balanced hemostasis with hypocoagulable and hypercoagulable features may occur in acute‐on‐chronic liver failure (ACLF). The characteristics prognostic impact of the coagulation profile ACLF are unknown. Consecutive patients (n = 36) acute decompensation (AD; n 24) were included. Blood samples for thromboelastometry (TE) obtained at admission 72 hours thereafter. was evaluated without those systemic inflammatory response syndrome. on transfusion requirements, bleeding events, short‐term...
COVID-19 coagulopathy linked to increased D-dimer levels has been associated with high mortality (Fei Z et al. in Clinical course and risk factors for of adult inpatients Wuhan, China: a retrospective cohort study. Lancet (London, England) 395(10229):1054–62, 2020). While is accepted as disseminated intravascular coagulation marker, rotational thromboelastometry (ROTEM) also detects fibrinolysis (Wright FL Fibrinolysis shutdown correlates thromboembolic events severe infection. J Am Coll...
Background and Aims Patients with liver disease acquire complex changes in their hemostatic system, which results a fragile rebalanced status. The status of the fibrinolytic system is controversial, as role dysfunction bleeding thrombosis patients cirrhosis. Here, we aimed to determine its relationship outcome acutely ill Approach Results We assessed plasma potential large cohort decompensated cirrhosis (AD, n = 52) or acute‐on‐chronic failure (ACLF, 57). Compared 40 healthy volunteers,...
Abstract Background Critically ill patients with coronavirus disease 19 (COVID-19) have a high fatality rate likely due to dysregulated immune response. Corticosteroids could attenuate this inappropriate response, although there are still some concerns regarding its use, timing, and dose. Methods This is nationwide, prospective, multicenter, observational, cohort study in critically adult COVID-19 admitted into Intensive Care Units (ICU) Spain from 12th March 29th June 2020. Using...
Pain is a clinical feature of COVID-19, however, data about persistent pain after hospital discharge, especially among ICU survivors scarce. The aim this study was to explore the incidence and characteristics new-onset its impact on Health-Related Quality Life (HRQoL), quantify presence mood disorders in critically ill COVID-19 survivors.This preliminary report PAIN-COVID trial (NCT04394169) presenting descriptive analysis survivors, following person interview 1 month discharge. assessed...
<h3>Objective</h3> To assess the burden of rare genetic variants and to estimate contribution known amyotrophic lateral sclerosis (ALS) genes in an Italian population-based cohort, we performed whole genome sequencing 959 patients with ALS 677 matched healthy controls. <h3>Methods</h3> We a cohort (Piemonte Valle d9Aosta Registry for [PARALS]). A panel 40 was analyzed identify potential disease-causing evaluate gene-wide among our population. <h3>Results</h3> total were compared controls...
Critically ill patients with COVID-19 are an especially susceptible population to develop post-intensive care syndrome (PICS) due acute respiratory distress (ARDS). Patients can suffer severe pain and may have long-term mental, cognitive, functional health deterioration after discharge. However, few controlled trials evaluating interventions for the prevention treatment of PICS. The study hypothesis is that a specific program based on early therapeutic education psychological intervention...
Patients with liver disease may acquire substantial changes in their hemostatic system, which are most pronounced patients who critically ill. Changes the quality of fibrin clot ill have not been studied detail. Here we assessed markers and effects coagulation factor concentrates acutely decompensated (AD) cirrhosis acute on chronic failure (ACLF).We measured plasma levels fibrinogen, XIII, prothrombin performed thrombin generation assays 52 AD patients, 58 ACLF 40 controls. In addition,...
Abstract Vitamin D deficiency is common in critically ill patients, and its role COVID-19 patients could be important. Its has been associated with respiratory distress syndrome, pulmonary fibrosis (through activation of the renin-angiotensin system), increased levels IL-2, cardiovascular adverse events. Various scientific societies recommend screening vitamin individuals at risk for deficiency. Despite that, demographics amongst a confirmed diagnosis are currently unknown. We propose study...
High doses of local anesthetic administered intra-articularly and peri-articularly during infiltration analgesia (LIA) for total knee arthroplasty (TKA) may have potential effects on patient hemodynamics. The aim this study was to know if hemodynamic changes are associated with LIA in patients undergoing TKA.In a prospective observational design, elective orthopedic surgery TKA treated consisting mixture ropivacaine (300 mg) epinephrine (1 were investigated selected parameters: heart rate...
Thromboelastometry is considered the best method to assesses hemostasis in liver disease. Diagnostic performance could be improved by adding protein C activators such as thrombomodulin or Protac®. We assessed changes ROTEM parameters after addition of Protac® patients with acute-on-chronic failure (ACLF), acute decompensation (AD), and healthy individuals (HI) define different patterns, considering standard velocity parameters, assess whether can improve definition pattern.Pre-test, we...
Mathematical models of thrombin generation (TG) that have been developed are based on a systems biology approach. Although this approach provides important information about the coagulation system, its clinical applicability is limited by complexity and number input variables required. The aim study was to develop semimechanistic model able describe TG in trauma control patients. A dataset containing longitudinal data assays factors from 40 patients 20 used for building. considered three...
Abstract Background: To explore the incidence and characteristics of new-onset pain, its impact on quality life (HRQoL), to quantify presence mood disorders in critically ill COVID-19 survivors. Methods: This is a preliminary report PAIN-COVID clinical trial (NCT04394169) presenting descriptive analysis critical COVID 19 survivors one month after hospital discharge. Pain was assed using Brief Inventory short form, Douleur Neuropathique 4 Questions test Catastrophizing Scale. Health related...