A5064121367- Meningioma and schwannoma management
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- COVID-19 and healthcare impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Melanoma and MAPK Pathways
- Cerebrospinal fluid and hydrocephalus
- Cardiac, Anesthesia and Surgical Outcomes
- Glioma Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Synthesis of Tetrazole Derivatives
- Synthesis and biological activity
- Radiation Dose and Imaging
- Spinal Fractures and Fixation Techniques
- Aortic Disease and Treatment Approaches
- CNS Lymphoma Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Sinusitis and nasal conditions
- Computational Drug Discovery Methods
- Congenital Heart Disease Studies
- Ultrasound in Clinical Applications
- Brain Metastases and Treatment
- Cardiac Arrest and Resuscitation
- Cancer Mechanisms and Therapy
- Surgical Simulation and Training
Hospital Clínic de Barcelona
2009-2024
Universitat de Barcelona
2010-2023
Neurological Surgery
2020-2023
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2022-2023
Institut de Virologie
2020-2021
University of Birmingham
2020
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
Merck (Germany)
2020
The recent development of the superior eyelid endoscopic transorbital approach (SETOA) offered a new route for management cavernous sinus and middle cranial fossa tumors. As result, constant anatomic landmark surgical pathway after drilling medial edge greater sphenoid wing (GSW) is represented by triangular-shaped bone ridge appearing as "crest."To perform an study to define this landmark, named "sagittal crest" (SC) seen from view.Four adult cadaveric specimens (8 sides) were dissected...
OBJECTIVE Different surgical routes have been used over the years to achieve adequate decompression of optic nerve in its canal including, more recently, endoscopic approaches performed either through endonasal corridor or transorbital one. The present study aimed detail and quantify amount bone removal around canal, achievable via medial-to-lateral lateral-to-medial trajectories. METHODS Five human cadaveric heads (10 sides) were dissected at Laboratory Surgical Neuroanatomy University...
Introduction Aneurysmal subarachnoid hemorrhage (aSAH) is a rare cause of stroke that poses significant morbidity and mortality, as it affects patients around the age 50 years. While advances in early aneurysm intervention have reduced mortality rates, many still experience poor outcomes due to brain injury (EBI) delayed cerebral ischemia (DCI). This study aims explore characteristics with neurological among status at admission, using comprehensive clinical neuroimaging data. Methods We...
BACKGROUND: The endoscopic superior eyelid transorbital route to the skull base is gaining progressive popularity in neurosurgical community. OBJECTIVE: To evaluate anatomy of middle cranial fossa from this novel ventral perspective reach through and show limits for possible safe drilling route. METHODS: Anatomic study was performed; 5 cadaveric specimens (ie, 10 sides) 2 dry skulls 4 were dissected. RESULTS: obtain a functional result, there are boundaries that correspond neurovascular...
Combined endonasal and transorbital multiportal surgery has been recently described for selected skull base pathologies. Nevertheless, a detailed anatomic description quantitative comprehensive study of the areas where these 2 endoscopic routes converge, so-called connection areas, are missing in scientific literature.To identify all structures avenues could be connected combined.Five cadaveric specimens (10 sides) were used dissection. Qualitative analysis each performed.At anterior cranial...
The endoscopic superior eyelid approach is a relatively novel mini-invasive technique that currently investigating for skull base cancers. However, questions remain regarding specific approach-related complications when treating different tumors. This study aims to analyze any surgical occurred in our preliminary consecutive experience, with focus on orbital outcome.
Postoperative deserved outcomes in acromegalic patients are to normalize serum insulin-like growth factor (IGF-1), reduce the tumoral mass effect, improve systemic comorbidities, and reverse metabolic alterations. Pituitary neuroendocrine tumors (PitNET) characterized present a heterogeneous behavior, hormone (GH)-secreting PitNET is not an exception. Promptly determining which affected by more aggressive essential guide optimal postoperative decision-making process [prognostic-based...
The aim of this study was to determine posture-induced changes in intracranial pressure (ICP) when patients with hydrocephalus or idiopathic hypertension remained supine for 1 hour and then sat up sitting 3 hours.Continuous ICP monitored using a fiberoptic extradural sensor in: 1) 259 free cerebrospinal fluid (CSF) flow through the craniovertebral junction Sylvian aqueduct, 2) 20 secondary aqueductal stenosis CSF junction, 3) 97 associated Chiari malformation. maximum difference (DeltaICP)...
Object Epidural pressures have been reported as being systematically higher than ventricular fluid pressures. These discrepancies attributed both to the characteristics of sensor and particular anatomy epidural space. To determine which these two possible causes better explains readings, authors compared pressure values obtained during simultaneous lumbar monitoring in 53 patients subdural 22 patients. The same nonfluid coupled device was used all compartments. Methods All 75 had normal...
Following recent studies measuring working area and surgical freedom of transcranial approaches, we aimed to quantify the gain achieved with progressive removal nasal structures during endoscopic endonasal suprasellar approach.Human cadaveric anatomic study.The width corridor was obtained measured in five cadaver heads using a computerized tracking system six steps: 1) standard approach monolateral lateralization middle turbinate; 2) bilateral turbinates; 3) turbinectomy; 4) 5)...
Postoperative cerebrospinal fluid (CSF) fistula is the most serious complication after transsphenoidal surgery.To analyze incidence of CSF endoscopic surgery for tumor removal in sellar region; to discuss associated factors and methods used closure.Retrospective study 67 patients (73 surgeries) operated via endoscopy at Hospital Vall D'Hebron Clinic Universidad de Barcelona, Spain. The data collected included: age, sex, hospitalization stay, suprasellar extension lesion, type tumor, evidence...
Compare the standard transsphenoidal sublabial microscopic approach with endoscopic concerning tumoral invasiveness and resection, complications of approaches time post operative hospitalisation.We realized a prospective, non randomised study 50 patients. They were operated between 2002 2006. All patients had sellar lesions different grades cavernous sinus as classified by Knosp. The variables included in our resection (total, subtotal partial), optic nerve lesion, postoperative...
Abstract The therapeutic benefit of approved BRAF and MEK inhibitors (BRAFi/MEKi) in patients with brain metastatic V600E/K–mutated melanoma is limited transient. Resistance largely occurs through the restoration MAPK signaling via paradoxical activation, highlighting need for more effective options. Aiming to address this clinical challenge, we characterized activity a potent, brain-penetrant paradox breaker BRAFi (compound 1a, C1a) as first-line therapy following progression upon treatment...
Glioblastoma (GBM) remains the most frequent and lethal primary brain tumor in adults, despite advancements surgical resection techniques adjuvant chemo- radiotherapy. The recurrence pattern (75-90%) occurs form of continuous growth from border cavity, thus emphasizing need for locoregional control. Fluorescence-guided using 5-ALA has been widely implemented protocols such tumors. Recent literature also highlights applicability 5-ALA-mediated photodynamic therapy to obtain control further....
OBJECTIVE: The endoscopic endonasal approach (EEA) has been proposed as an alternative in the surgical removal of ventral brainstem lesions. However, feasibility and limitations this to treat such pathologies are still poorly understood. This study aimed report our experience five consecutive cases intrinsic lesions that were managed via EEA, well specific anatomy each case. METHODS: All patients treated a single center by multidisciplinary team between 2015 2019. Before surgery, dedicated...