A5039443818- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Body Contouring and Surgery
- Esophageal and GI Pathology
- Thyroid and Parathyroid Surgery
- Gastric Cancer Management and Outcomes
- Agriculture and Rural Development Research
- Thyroid Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Drug Transport and Resistance Mechanisms
- Cardiovascular Disease and Adiposity
- Adrenal and Paraganglionic Tumors
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Venous Thromboembolism Diagnosis and Management
- Diagnosis and Treatment of Venous Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Pituitary Gland Disorders and Treatments
- Hormonal Regulation and Hypertension
- Pharmacology and Obesity Treatment
- Adipose Tissue and Metabolism
Centre Hospitalier Universitaire de Lille
2016-2025
Inserm
2016-2025
European Genomic Institute for Diabetes
2015-2025
Institut Pasteur de Lille
2021-2025
Recherche translationnelle sur le diabète
2017-2024
Université de Lille
2014-2024
Centre Oscar Lambret
2017-2023
Hôpital Claude Huriez
2016-2020
Laboratoire de Recherche Vasculaire Translationnelle
2017
Générale de Santé
2015-2016
Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and nuclear FXR. BA sequestrants (BAS) complex bile in intestinal lumen decrease FXR activity. The BAS–BA also induces glucagon-like peptide-1 (GLP-1) production by L cells potentiates β-cell glucose-induced insulin secretion. Whether is expressed controls GLP-1 unknown. Here, we show that activation decreases proglucagon expression interfering with glucose-responsive factor Carbohydrate-Responsive Element...
In Brief Objectives: To compare the long-term benefit of gastric bypass [Roux-en-Y (RYGB)] versus adjustable banding (AGB) on nonalcoholic fatty liver disease (NAFLD) in severely obese patients. Background: NAFLD improves after weight loss surgery, but no histological study has compared effects various bariatric interventions. Methods: Participants consisted 1236 patients (body mass index = 48.4 ± 7.6 kg/m2), enrolled a prospective longitudinal for up to 5 years RYGB (n 681) or AGB 555)....
Metabolic dysfunction-associated steatotic liver disease (MASLD) exhibits considerable variability in clinical outcomes. Identifying specific phenotypic profiles within MASLD is essential for developing targeted therapeutic strategies. Here we investigated the heterogeneity of using partitioning around medoids clustering based on six simple variables a cohort 1,389 individuals living with obesity. The identified clusters were applied across three independent cohorts biopsy (totaling 1,099...
Background & aims The value of non-invasive tests for monitoring the resolution significant liver fibrosis after treatment is poorly investigated. We compared performances six to predict bariatric surgery. Methods Participants were individuals with obesity submitted needle biopsy at time surgery, and 12 and/or 60 months calculated fibrosis-4 index (FIB-4), NAFLD score (NFS), AST platelet ratio (APRI), Hepatic (HFS), Fibrosis (FNI), Liver risk (LRS) each point, their predicting (F ≥ 2) its...
Postprandial hyperinsulinemic hypoglycemia (PHH) is often reported after Roux-en-Y gastric bypass (RYGB). In the absence of a prospective study, clinical and biological determinants PHH remain unclear.To determine incidence predictive factors RYGB.Participants were 957 RYGB patients enrolled in an ongoing longitudinal cohort study. We analyzed results oral glucose tolerance test (OGTT) routinely performed before surgery 1 and/or 5 years after. was defined as blood < 50 mg/dL AND plasma...
Background: Lymph node dissection (LND) in primary treatment of differentiated thyroid carcinoma is controversial. The aim our retrospective study was to analyse the risk factors post-thyroidectomy complications and assess morbidity lymph dissection, especially central neck compartment, since prophylactic has not been proven bring an overall survival benefit. Methods: We performed a analysis postoperative from 1547 consecutive patients with academic department endocrine surgery over period...
The potential benefit of the centralization Bariatric surgery (BS) remains debated. aim this study was to evaluate impact on 90-day mortality an innovative organization aiming at centralizing care severe postoperative complications BS.The for complication after BS implemented by French Authorities in 2013 Nord-Pas-de-Calais Region, France. This unique formalized network (OSEAN), coordinated 1 tertiary referral center, enrolled all regional institutions performing bariatric surgery. Data were...
OBJECTIVE Bariatric surgery is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, cluster 5 (C5) 6 (C6) are high-risk clusters developing comorbidities, while 4 (C4) a low-risk cluster. We investigated bariatric outcomes, hypothesizing that benefit most due to great potential metabolic improvement. RESEARCH DESIGN AND METHODS allocated...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
<p dir="ltr">Objective</p><p dir="ltr">Bariatric surgery (BS) is an effective treatment option for individuals with obesity and type 2 diabetes (T2D). However, whether outcomes in subtypes of at risk T2D and/or comorbidities (Tübingen Clusters) differ, unknown. Of these, clusters 5 6 (C5, C6) are high-risk developing comorbidities, while cluster 4 (C4) a low-risk cluster. We investigated BS outcomes, hypothesizing benefit most due to great potential metabolic...
Steatotic liver disease (SLD) is frequent in individuals with obesity. In this study, type 2 diabetes (T2D), sex, and menopausal status were combined to refine the stratification of obesity regarding risk advanced SLD gain further insight into physiopathology. This study enrolled 1446 participants from ABOS cohort (NCT01129297), who underwent extensive phenotyping, including histology transcriptome profiling. Hierarchical clustering was applied classify participants. The prevalence metabolic...
To investigate the way robotic assistance affected rate of complications in bariatric surgery at expert and laparoscopic facilities.
To assess recurrence according to the type of surgery for primary hyperparathyroidism (pHPT) in multiple endocrine neoplasia 1 ( MEN1 ) patients and identify risk factors after initial surgery.