A5038748850- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- ECG Monitoring and Analysis
- Ion channel regulation and function
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Cardiomyopathy and Myosin Studies
- Diabetes Treatment and Management
- Cardiac Imaging and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac Structural Anomalies and Repair
- Heart Failure Treatment and Management
- Transplantation: Methods and Outcomes
- Diabetes Management and Research
- Mechanical Circulatory Support Devices
- Chronic Myeloid Leukemia Treatments
- Adipose Tissue and Metabolism
- Personal Information Management and User Behavior
- Wnt/β-catenin signaling in development and cancer
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Phagocytosis and Immune Regulation
- Non-Invasive Vital Sign Monitoring
- Extracellular vesicles in disease
Okayama University
2011-2025
Intermittent arm ischemia before percutaneous coronary intervention induces remote ischemic preconditioning (RIPC) and attenuates myocardial injury in patients with infarction. Several studies have shown that intermittent increases flow is related to autonomic nerve system. The aim of this study was determine whether vasodilatation other arteries assess changes the system during humans. We measured change right brachial artery diameter left through three cycles 5-min inflation (200 mmHg)...
Risk stratification in patients with Brugada syndrome for primary prevention of sudden cardiac death is still an unsettled issue. A recent consensus statement suggested the indication implantable cardioverter defibrillator (ICD) depending on clinical risk factors present (spontaneous type 1 electrocardiogram (ECG) [Sp1], history syncope [syncope], and ventricular fibrillation during programmed electrical stimulation [PES+]). The ICD majority patients, however, remains unclear.A total 218...
Background Effects of sodium‐glucose cotransporter 2 inhibitors on reducing hospitalization for heart failure have been reported in randomized controlled trials, but their effects patients with preserved ejection fraction ( HF p EF ) are unknown. This study aimed to evaluate the drug efficacy luseogliflozin, a inhibitor, type diabetes mellitus and . Methods Results We performed multicenter, open‐label, randomized, trial comparing luseogliflozin 2.5 mg once daily voglibose 0.2 3 times...
It has been believed that electrophysiologic abnormality of the epicardial region right ventricular free wall may play an important role in arrhythmogenesis phase 2 reentry Brugada syndrome, but clinical evidence occurrence arrhythmias at not evaluated. In this study, we evaluated site-specific inducibility fibrillation (VF) and origin spontaneous premature contractions (PVCs) patients with syndrome.Forty-five Brugada-type ECG were enrolled study. Spontaneous PVCs recorded 9 patients....
<h3>Objective</h3> Multi-detector coronary CT angiography (CCTA) can detect stenosis, but it has a limited ability to evaluate myocardial perfusion. We evaluated the usefulness of first-pass CT-myocardial perfusion imaging (MPI) in combination with CCTA for diagnosing artery disease (CAD). <h3>Methods</h3> A total 145 patients suspected CAD were enrolled. used 64-row multi-detector (Definition Flash, Siemens). The same data CT-MPI without drug loading. Images reconstructed by examining...
Hospitalizations are common in patients with heart failure and associated high mortality, readmission economic burden. Detecting early signs of worsening may enable earlier intervention reduce hospitalizations. The HeartLogic algorithm is designed to predict using diagnostic data from multiple device sensors. main objective this analysis was evaluate the sensitivity alert calculation predicting events (HFEs). We also evaluated false positive rate (FPR) compared incidence HFEs occurring a...
Background:Patients with pulmonary arterial hypertension (PAH) are currently treated combination therapy of PAH-targeted drugs. Reverse right ventricular (RV) remodeling after lung transplantation (LTx) in patients end-stage PAH despite drugs has not been fully elucidated.
Abstract Aims The HINODE study aimed to analyse rates of mortality, appropriately treated ventricular arrhythmias (VA), and heart failure in Japanese patients compared with those Western patients. Methods results After treatment decisions following contemporary practice Japan, were prospectively enrolled into four cohorts: (i) internal cardioverter‐defibrillator (ICD), (ii) cardiac resynchronization therapy (CRT) defibrillator (CRT‐D), (iii) standard medical (‘non‐device’: ND), or (iv)...
Abstract Sodium-glucose cotransporter 2 inhibitors could reduce cardiovascular events in patients with heart failure irrespective of diabetes status. In this prespecified sub-analysis randomised-controlled trial, we investigated the efficacy luseogliflozin (2.5 mg daily), a sodium–glucose inhibitor, that voglibose (0.6 an alpha-glucosidase on high-risk lipid profile and inflammatory markers type-2 failure. Among 157 studied, there were no significant differences mean malondialdehyde LDL or...
Vascular medial calcification is often observed in patients with arteriosclerosis. It also associated systolic hypertension, wide pulse pressure, and fluctuation of blood which results cardiovascular events. Eicosapentaenoic acid (EPA) has been shown to suppress vascular previous animal experiments. We investigated the inhibitory effects EPA on Wnt signaling, one important signaling pathways involved calcification. Intake food containing 5% resulted upregulation mRNA expression Klotho, an...
This study sought to examine the action potential duration restitution (APDR) property and conduction delay in Brugada syndrome (BrS) patients. A steeply sloped APDR curve are known be important determinants for occurrence of ventricular fibrillation (VF).Endocardial monophasic was obtained from 39 BrS patients 9 control subjects using contact electrode method. Maximum slopes were at both right outflow tract (RVOT) apex (RVA). The onset activation (OAD) after premature stimulation examined...
Sodium glucose co-transporter 2 inhibitors have diuretic effects in both patients with glycosuria and natriuresis. We sought to assess the effect of luseogliflozin on estimated plasma volume (ePV) type diabetes heart failure preserved ejection fraction (HFpEF).