A5008429849- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Connexins and lens biology
- Heart Failure Treatment and Management
- Cardiac electrophysiology and arrhythmias
- Heart Rate Variability and Autonomic Control
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Axon Guidance and Neuronal Signaling
- Chemotherapy-induced cardiotoxicity and mitigation
- Congenital Heart Disease Studies
- Antibiotics Pharmacokinetics and Efficacy
- Non-Invasive Vital Sign Monitoring
- Neurogenesis and neuroplasticity mechanisms
- Pneumonia and Respiratory Infections
- Cardiovascular and exercise physiology
- Cardiac Valve Diseases and Treatments
- Mitochondrial Function and Pathology
- Cardiovascular Issues in Pregnancy
- Glaucoma and retinal disorders
- Vascular Anomalies and Treatments
- Lysosomal Storage Disorders Research
- Lymphoma Diagnosis and Treatment
- Viral Infections and Immunology Research
Tohoku University
2016-2025
Oita University
2012-2025
Oita Prefectural Hospital
2018-2025
Tohoku University Hospital
2016-2024
Kitasato University
2019-2024
Yokosuka Kyosai Hospital
2023
Kumamoto University
2017-2022
Tokyo University of Science
2021
Tokyo University of Pharmacy and Life Sciences
2021
Nagasaki University
2019
Although balloon pulmonary angioplasty (BPA) improves haemodynamics and short-term prognosis in patients with inoperable chronic thrombo-embolic hypertension (CTEPH), the long-term effects of BPA, procedure-related complications remain to be fully elucidated.From July 2009 October 2016, we performed a total 424 BPA sessions 84 consecutive CTEPH. We used 3D reconstructed computed tomography determine target lesions arteries optical select size, if needed. In 77 (92%) who completed treatment...
Background:It remains to be determined whether balloon pulmonary angioplasty (BPA) improves biventricular cardiac functions and flow in patients with chronic thromboembolic hypertension (CTEPH).Methods Results:We enrolled 30 consecutive inoperable CTEPH who underwent BPA, carried out serial magnetic resonance imaging (CMR; M/F, 9/21; median age, 65.2 years). No patient died during the treatment or follow-up period. BPA significantly improved WHO functional class (III/IV, 83.0 4.0%), 6-min...
Vericiguat has been used to treat patients with heart failure reduced ejection fraction (HFrEF) who demonstrated worsening despite treatment other guideline-directed medical therapies. The haemodynamic effects of vericiguat remain unclear.
The mammalian neocortex is composed of various types neurons that reflect its laminar and area structures. It has been suggested not only intrinsic but also afferent-derived extrinsic factors are involved in neuronal differentiation during development. However, the role molecular mechanism such almost unknown. Here, we attempted to identify molecules expressed thalamus affect cortical cell First, thalamus-specific were sought by comparing gene expression profiles developing rat cortex using...
Pulmonary arterial hypertension with systemic dysfunctions, including metabolic disorders and renal dysfunction, has a poor prognosis. However, it remains to be elucidated whether chronic thromboembolic pulmonary (CTEPH) is also associated if so, balloon angioplasty (BPA) improves them.Fifty-five consecutive patients who underwent BPA from March 2012 December 2014 for glycemic control, lipid profiles, vascular function, nutritional status were examined. The analyses performed before after...
Heart failure with preserved left ventricular ejection fraction (HFpEF) is a serious health problem worldwide, as no effective therapy yet available. We have previously demonstrated that our low-intensity pulsed ultrasound (LIPUS) and safe for angina dementia. In this study, we aimed to examine whether the LIPUS also ameliorates cardiac diastolic dysfunction in mice.
Although balloon pulmonary angioplasty (BPA) improves the hemodynamics and prognosis of patients with inoperable chronic thromboembolic hypertension (CTEPH), mechanisms improvement in oxygenation remain to be elucidated.From August 2013 May 2015, we performed a total 113 BPA procedures 24 CTEPH (mean 4.7 per patient). Median age was 70 [60, 74] years 18 were female (75%). We examined hemodynamics, respiratory functions, intrapulmonary shunt before after procedure. Mean arterial pressure (37...
Neutrophil extracellular traps (NETs) are web-like structures consisting of decondensed chromatin DNA and contents granules, such as myeloperoxidase (MPO) neutrophil elastase (NE). NETs usually released from neutrophils undergoing NETosis, a neutrophil-specific cell death mode characterized by the collapse disappearance membranes nuclear envelopes. It is well known that production reactive oxygen species (ROS) triggers NETosis NET formation. However, details intracellular signaling...
Neuronal abundance and thickness of each cortical layer are specific to area, but how this fundamental feature arises during development remains poorly understood. While some area-specific features controlled by intrinsic cues such as morphogens transcription factors, the exact influence mechanisms action extrinsic cortex, in particular thalamic axons, have not been fully established. Here, we identify a thalamus-derived factor, VGF, which is indispensable for thalamocortical axons maintain...
A woman in her 20s, with no significant medical history, presented lower abdominal pain.The patient was initially diagnosed appendicitis.However, computed tomography revealed widespread free air and atypical liver en-hancement, suggesting the spread of inflammation to capsule (Figure 1), gastrointestinal perforation, resultant peritonitis.There were intrathoracic or intraabdominal lesions, such as cystic pneumatosis.Given
A 69-year-old woman presented with heart failure and progressive muscle weakness was diagnosed as anti-mitochondrial antibody (AMA) myositis cardiac involvement. Immunosuppressive therapy prednisolone intravenous cyclophosphamide significantly improved the symptoms, hemodynamics, function. Cardiac magnetic resonance (CMR) T1 T2 mapping showed elevated native T1, T2, extracellular volume fractions during exacerbation (day 37) compared to pre-hospitalization values (10 months before admission)...
The UNC-5 family of netrin receptors is known to regulate axon guidance, cell migration, and survival. We have previously demonstrated that unc5d, one the member genes, specifically expressed in layer 4 developing rat neocortex (Zhong Y, Takemoto M, Fukuda T, Hattori Murakami F, Nakajima D, Nakayama Yamamoto N. 2004. Identification genes are upper layers neocortex. Cereb Cortex. 14:1144–1152). However, role UNC5D cortical development still unknown. In this study, we revealed unc5d was highly...
Abstract Aim To determine whether there are differences in size between the male and female pronuclei immediately before pronuclear membrane breakdown ( PNMBD ) to evaluate influence normal birth rates. Methods Time‐lapse photography was used measure of each pronucleus, while outcome 71 frozen‐thawed single blastocyst transfers patients receiving hormone therapy analyzed retrospectively. The measurements were made 4 hours , corresponding 16‐20 after insemination or intracytoplasmic sperm...
It is widely known that the incidence of pulmonary arterial hypertension (PAH) higher in female, whereas prognosis poorer male patients. However, sex differences hemodynamic response to and long-term with PAH-targeted treatment modern era remain be fully elucidated. We examined 129 consecutive PAH patients (34 males 95 females) diagnosed our hospital from April 1999 October 2014, assessed changes therapy. Female had better 5-year survival compared (74.0 vs. 53.4%, P = 0.003); however, age...
This study proposes an objective method of quantifying the vortex flow in pulmonary arteries to compare duration its presence before and after balloon angioplasty (BPA) patients with chronic thromboembolic hypertension (CTEPH).Thoracic 4D-flow magnetic resonance imaging was performed 28 CTEPH BPA. Planes were set evaluate volume rate (VFR), duration, area backward trunk, which is a component flow. The full width at half maximum (FWHM) peak time course VFR assessed quantify vortical...
The aim of this study was to assess clinical and pulmonary thin-section CT findings in patients with acute Pseudomonas aeruginosa (PA) infection.We retrospectively identified 44 PA pneumonia who had undergone chest examinations between January 2004 December 2010. We excluded nine concurrent infections. final group comprised 35 (21 males, 14 females; age range 30-89 years, mean 66.9 years) pneumonia. patients' were assessed. Parenchymal abnormalities, enlarged lymph nodes pleural effusion...