A5000353595- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Congenital Heart Disease Studies
- Cardiac Imaging and Diagnostics
- Vascular Anomalies and Treatments
- Heart Failure Treatment and Management
- Blood Coagulation and Thrombosis Mechanisms
- Selenium in Biological Systems
- Atrial Fibrillation Management and Outcomes
- Liver Disease and Transplantation
- Cardiac Arrhythmias and Treatments
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Peptidase Inhibition and Analysis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Valve Diseases and Treatments
- Signaling Pathways in Disease
- Transplantation: Methods and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Chemotherapy-induced cardiotoxicity and mitigation
- Renin-Angiotensin System Studies
- Advanced X-ray and CT Imaging
Tohoku University
2015-2025
Tohoku University Hospital
2016-2025
Charité - Universitätsmedizin Berlin
2024
University of Tokyo Hospital
2023
University of Miyazaki
2023
Tenri Hospital
2023
International University of Health and Welfare
2023
Okayama Medical Center
2022
National Hospital Organization
2022
Policlinico S.Orsola-Malpighi
2022
Although balloon pulmonary angioplasty (BPA) improves haemodynamics and short-term prognosis in patients with inoperable chronic thrombo-embolic hypertension (CTEPH), the long-term effects of BPA, procedure-related complications remain to be fully elucidated.From July 2009 October 2016, we performed a total 424 BPA sessions 84 consecutive CTEPH. We used 3D reconstructed computed tomography determine target lesions arteries optical select size, if needed. In 77 (92%) who completed treatment...
Background: Excessive proliferation and apoptosis resistance of pulmonary artery smooth muscle cells (PASMCs) are key mechanisms arterial hypertension (PAH). Despite the multiple combination therapy, a considerable number patients develop severe (PH) because lack diagnostic biomarker antiproliferative therapies for PASMCs. Methods: Microarray analyses were used to identify novel therapeutic target PAH. In vitro experiments, including lung serum samples from with PAH, cultured PAH-PASMCs,...
Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark pulmonary hypertension (PH). Yet, why some ECs die others proliferate how this contributes to vascular remodeling unclear. We hypothesized that differential response may: (1) relate different EC subsets, namely artery (PAECs) versus microvascular (MVECs); (2) be attributable autophagic activation in both subtypes; (3) cause replacement MVECs by PAECs with subsequent distal vessel muscularization.
Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells (VSMCs) by oxidative stress and promotes VSMC proliferation. However, the role of extracellular CyPA its receptor Basigin (Bsg, encoded Bsg) in pathogenesis pulmonary hypertension (PH) remains to be elucidated.To determine CyPA/Bsg signaling development PH.In arteries patients with PH, immunostaining revealed strong expression Bsg. The CyPA(±) Bsg(±) mice exposed normoxia did not differ morphology compared their littermate...
Background:It remains to be determined whether balloon pulmonary angioplasty (BPA) improves biventricular cardiac functions and flow in patients with chronic thromboembolic hypertension (CTEPH).Methods Results:We enrolled 30 consecutive inoperable CTEPH who underwent BPA, carried out serial magnetic resonance imaging (CMR; M/F, 9/21; median age, 65.2 years). No patient died during the treatment or follow-up period. BPA significantly improved WHO functional class (III/IV, 83.0 4.0%), 6-min...
Rationale: Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling with aberrant artery smooth muscle cells (PASMCs) proliferation, endothelial dysfunction, and extracellular matrix remodeling. Objective: Right ventricular (RV) failure an important prognostic factor in PAH. Thus, we need to elucidate a novel therapeutic target both PAH RV failure. Methods Results: We performed microarray analysis PASMCs from patients (PAH-PASMCs) controls. found ADAMTS8...
Vericiguat has been used to treat patients with heart failure reduced ejection fraction (HFrEF) who demonstrated worsening despite treatment other guideline-directed medical therapies. The haemodynamic effects of vericiguat remain unclear.
Objective— Chronic thromboembolic pulmonary hypertension (CTEPH) is a fatal disease that distinct from arterial (PAH). Although CTEPH characterized by obstruction of major artery because chronic thrombus, it remains unclear whether associated with prothrombotic condition. Approach and Results— In addition to conventional markers, GTP-bound levels Rap1, RhoA, RalA, Rac1, Ras in platelets, which are implicated for platelet activation, were measured patients without (non-PH, n=15), PAH (n=19),...
Pulmonary arterial hypertension with systemic dysfunctions, including metabolic disorders and renal dysfunction, has a poor prognosis. However, it remains to be elucidated whether chronic thromboembolic pulmonary (CTEPH) is also associated if so, balloon angioplasty (BPA) improves them.Fifty-five consecutive patients who underwent BPA from March 2012 December 2014 for glycemic control, lipid profiles, vascular function, nutritional status were examined. The analyses performed before after...
Background Circulating proteins are exposed to vascular endothelial layer and influence their functions. Among them, adipsin is a member of the trypsin family peptidases mainly secreted from adipocytes, monocytes, macrophages, catalyzing rate-limiting step alternative complement pathway. However, its pathophysiological role in cardiovascular disease remains be elucidated. Here, we examined whether serum levels have prognostic impact patients with coronary artery disease. Methods Results In...
The contemporary outcome of balloon pulmonary angioplasty (BPA) and endarterectomy (PEA) in patients with chronic thromboembolic hypertension (CTEPH) are unclear.
Pulmonary hypertension is a fatal disease; however, its pathogenesis still remains to be elucidated. Thrombin-activatable fibrinolysis inhibitor (TAFI) synthesized by the liver and inhibits fibrinolysis. Plasma TAFI levels are significantly increased in chronic thromboembolic pulmonary (CTEPH) patients.To determine role of activated (TAFIa) development CTEPH.Immunostaining showed that binding partner thrombomodulin (TM) were highly expressed arteries (PAs) thrombus patients with CTEPH....
Cyclophilin A (CyPA) is secreted from vascular smooth muscle cells, inflammatory and activated platelets in response to oxidative stress. We have recently demonstrated that plasma CyPA level a novel biomarker for diagnosing coronary artery disease. However, it remains be elucidated whether levels also prognostic impact such patients.In 511 consecutive patients undergoing diagnostic angiography, we measured the of CyPA, high-sensitivity C-reactive protein (hsCRP), brain natriuretic peptide...
The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) remains to be elucidated. Thrombin-activatable fibrinolysis inhibitor (TAFI) inhibits fibrinolysis. It elucidated whether TAFI is directly involved in the CTEPH. We examined potential involvement CTEPH humans.We enrolled 68 consecutive patients undergoing right heart catheterization our hospital, including those with (n=27), arterial (n=22), and controls (non-pulmonary hypertension, n=19). Whole blood clot lysis assay...
Although balloon pulmonary angioplasty (BPA) improves the hemodynamics and prognosis of patients with inoperable chronic thromboembolic hypertension (CTEPH), mechanisms improvement in oxygenation remain to be elucidated.From August 2013 May 2015, we performed a total 113 BPA procedures 24 CTEPH (mean 4.7 per patient). Median age was 70 [60, 74] years 18 were female (75%). We examined hemodynamics, respiratory functions, intrapulmonary shunt before after procedure. Mean arterial pressure (37...
A 69-year-old woman presented with heart failure and progressive muscle weakness was diagnosed as anti-mitochondrial antibody (AMA) myositis cardiac involvement. Immunosuppressive therapy prednisolone intravenous cyclophosphamide significantly improved the symptoms, hemodynamics, function. Cardiac magnetic resonance (CMR) T1 T2 mapping showed elevated native T1, T2, extracellular volume fractions during exacerbation (day 37) compared to pre-hospitalization values (10 months before admission)...
Various cardiovascular diseases cause acquired von Willebrand syndrome (AVWS), which is characterized by a decrease in high-molecular-weight (large) factor (VWF) multimers. Mitral regurgitation (MR) has been reported as of AVWS. However, much remains unclear about AVWS associated with MR.
Background: Heart failure (HF) is a complex clinical syndrome, resulting from structural and/or functional cardiac disease. The aim of this study was to determine whether the activity Rho-kinase, which has been identified as an important therapeutic target cardiovascular disease, enhanced in HF patients. Methods and Results: Total phosphorylated forms myosin binding subunit (t-MBS p-MBS), substrate were measured on western blotting circulating leukocytes, p-MBS/t-MBS ratio defined index...
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the arteries (PAs). We have previously demonstrated usefulness of optical coherence tomography …