We present historical and geomorphological evidence of a regularity in earthquake recurrence at three different sites plate convergence around the Japan arcs. The shows that larger an is, longer is following quiet period. In other words, time interval between two successive large earthquakes approximately proportional to amount coseismic displacement preceding not earthquake. enables us, principle, predict approximate occurrence earthquakes. data set includes 1) document describing repeated...

To provide a detailed record of relatively rare thrust surface rupture and examine its active tectonic implications, we have conducted field mapping the associated with 2005 M w 7.6 Kashmir earthquake. Despite difficulty arising from massive earthquake-induced landslides along rupture, found that typical pressure ridges warps extend northwestward for distance ∼70 km, northeast-side-up vertical separation up to ∼7 m. Neither main frontal nor boundary is responsible earthquake, but three...

The ∼2500 km long Himalayan arc has experienced three large to great earthquakes of M w 7.8 8.4 during the past century, but none produced surface rupture. Paleoseismic studies have been conducted last decade begin understanding timing, size, rupture extent, return period, and mechanics faulting associated with occurrence rupturing along Frontal Thrust (HFT) system India Nepal. previous limited about nine sites western two‐thirds HFT extending through northwest southern border We present...

It has demonstrated that the recognition of triacylated lipopeptides by Toll-like receptor (TLR) 2 requires TLR1 as a coreceptor. In NF-kappaB reporter assay system in which human embryonic kidney 293 cells were transfected with TLR2 and together an luciferase gene, S-(2,3-bispalmitoyloxypropyl)-N-palmitoyl-Cys-Lys-Lys-Lys-Lys (Pam(3)CSK(4)) Pam(3)CSSNA recognized TLR2/TLR1, but level was unexpectedly very low. However, cotransfection CD14 drastically enhanced TLR2/TLR1. The CD14-induced...

Numerous newly-identified traces of active faults in the Himalayan foothill zone along HFF around Chandigarh, Pinjore Dun, piedmont Lower Siwalik hill front and within Tertiary range reveal pattern thrust strike-slip faulting, striking parallel to principal structural trend (NNW-SSE) orogenic belt. The Chandigarh Fault, Garden Fault Barsar have vertically dislocated, warped backtilted fluvial alluvial-fan surfaces made up Late Pleistocene-Holocene sediments. West- southwest-facing fault...

Abstract Background There is little information regarding the clinical behaviour of hilar cholangiocarcinoma after curative resection. Methods A retrospective study was undertaken 79 consecutive patients with who had undergone major hepatectomy (three or more Couinaud segments) concomitant caudate lobectomy, and negative resection margins. Sites initial disease recurrence were classified as locoregional (porta hepatis) distant (intrahepatic, peritoneal, para-aortic lymph nodal...

Abstract Since the treatment window of thrombolytic therapy for stroke is limited, new remains to be developed. We have recently developed low-intensity pulsed ultrasound (LIPUS) improve cognitive dysfunction in mouse models vascular dementia and Alzheimer’s disease. Here, we further aimed examine whether our LIPUS improves neurological recovery from ischemic stroke, if so, elucidate mechanisms involved. In a model middle cerebral artery occlusion (MCAO), applied (32 cycles, 193 mW/cm 2 )...

Heart failure with preserved left ventricular ejection fraction (HFpEF) is a serious health problem worldwide, as no effective therapy yet available. We have previously demonstrated that our low-intensity pulsed ultrasound (LIPUS) and safe for angina dementia. In this study, we aimed to examine whether the LIPUS also ameliorates cardiac diastolic dysfunction in mice.

The prevalence of Alzheimer's disease (AD) has been rapidly increasing worldwide. We have developed a novel angiogenic therapy with low-intensity pulsed ultrasound (LIPUS), which is effective and safe in animal models AD vascular dementia. performed two trials LIPUS for (mild cognitive impairment due to mild AD); roll-in open trial safety, randomized, double-blind, placebo-controlled (RCT) efficacy safety. was whole brain through the bilateral temporal bones one hour 3 times week as session...

Research Article| September 01, 2008 Long recurrence interval of faulting beyond the 2005 Kashmir earthquake around northwestern margin Indo-Asian collision zone Hisao Kondo; Kondo * 11Active Fault Center, AIST (National Institute Advanced Industrial Science and Technology), Geological Survey Japan, Central 7, 1-1-1 Higashi, Tsukuba 305-8567, Japan *E-mail: kondo-h@aist.go.jp. Search for other works by this author on: GSW Google Scholar Takashi Nakata; Nakata 22Faculty Environmental Studies,...

Fault scarps and uplifted terraces in young alluvium are frequent occurrences along the trace of northerly dipping Himalayan frontal thrust (HFT). Generally, it was expected that 25 April 2015 M  7.8 Gorkha earthquake Nepal would produce fresh fault trace. Contrary to expectation, Interferometric Synthetic Aperture Radar aftershock studies soon indicated rupture HFT confined subsurface, terminating on order 50 km north HFT. We undertook a field survey faults lineaments within Kathmandu...

The Pyramid Lake fault zone (PLFZ) is a 50‐km‐long, active northwest‐trending right‐lateral in the northern Walker Lane, located ∼30  km east of Reno, Nevada. Previous paleoearthquake and slip‐rate studies report that has produced four surface‐rupturing paleoearthquakes since 15,475±720  cal B.P., three which occurred after 8980±260  cal B.P., had an average minimum slip rate 2.6±0.3  mm/yr late Pleistocene. These observations imply coseismic offset for each averaged 7–9 m, larger than...

Distinctive ruptures of the surface faulting which generated destructive 1995 Hyogoken-Nanbu Earthquake (Ms=7.2) appeared along Nojima fault, an active fault on northwestern coast Awaji island, Japan. The in island extend southwestward continuously for about 9km from Easki near epicenter to Toshima Hokudan town, and caused prominent right-latearl off-sets 1.9m at maximum roads, paddy dikes with vertical displacement 1.2m maximum, while no large has been reported Kobe where major damage...

The numerous coral reefs in the Ryukyu Islands provide detailed evidence of relationship between reef development and late Holocene sea-level changes. islands belong to tectonically active island arc have experienced many destructive earthquakes historical period. It is, therefore, assumed that been terraced at various elevations, due sudden uplift associated with major earthquakes, sites during period post-glacial eustatic In this paper, authors attempted restore curve as follows. First,...

Prominent Holocene marine terraces classified into four levels in southern Boss, have recorded the history of seismic crustal deformation by large earthquakes along Sagami trough. The mode and amount movements are discussed based on relative sea-level curve reconstructed from topographical chronological data including 36 14 C dates. 1. indicates times sudden drops at 6, 150 y. B. P., 4, 350 2, 850y. P. 250y. caused upheavals associated with -earthquakes like that Genroku Taisho type (Fig....

Pulmonary arterial hypertension is characterized by abnormal proliferation of pulmonary artery smooth muscle cells and vascular remodeling, which leads to right ventricular (RV) failure. Bsg (Basigin) a transmembrane glycoprotein that promotes myofibroblast differentiation, cell proliferation, matrix metalloproteinase activation. CyPA (cyclophilin A) binds its receptor inflammatory recruitment. We previously reported cardiac fibrosis failure in the left ventricle response pressure-overload...

We invented a completely new simple method and equipment necessary for high-resolution active fault studies. Vertical thin sections of unconsolidated soil layers are extracted by newly sampler named "Geo-slicer".Extracted can be taken to laboratory close examination or displayed at meeting even stored future re-examinations (Fig. 1). This enables us carry on analyses not only in studies but also other fields Quaternary sciences with less expenditure time, labor money.We made three...

In 1771, according to several trustworthy historical records, a huge tsunami named the Meiwa Tsunami washed southern part of Ryukyu Islands killing about 12, 000 people. The attributed probably large earthquake generated by submarine thrust fault along Trench. consisting Miyako, Irabu, Shimoji, Tarama, Ishigaki, Iriomote and other small islands are fringed coral reefs, Holocene coralline boulders possibly transported past tsunamis, extensively distributed on land reef flats. Among these...

Abstract A tsunamigenic sand layer is present in coastal sequences of the Masuda Plain, southwest Japan. The radiometric age has been estimated at 930 ± 80 years BP. It proposed that deposit product a large historic tsunami believed to have occurred Japan Sea on 16 June 1026 AD.