A5035583513- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Gastrointestinal disorders and treatments
- Vascular anomalies and interventions
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
- Esophageal and GI Pathology
- Nutrition and Health in Aging
- Appendicitis Diagnosis and Management
- Abdominal vascular conditions and treatments
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Renal cell carcinoma treatment
- Occupational and environmental lung diseases
- Cancer Treatment and Pharmacology
- Renal and Vascular Pathologies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hernia repair and management
- Cancer Genomics and Diagnostics
- Case Reports on Hematomas
Kanazawa Medical University Hospital
2019-2024
Kanazawa Medical University
2019-2021
Japanese Red Cross Kanazawa Hospital
2017-2020
Shizuoka Cancer Center
2015-2018
Kanazawa University
1977-2017
Keio University
2014
Nihon University
2013
Mitsuwadai General Hospital
2013
National Research Institute of Police Science
2012
Asanogawa General Hospital
2012
Methotrexate (MTX), a folic acid antagonist, is widely used in the treatment of neoplasms, psoriasis and rheumatoid arthritis. Despite its efficacy, MTX sometimes finds limited application because adverse effects, including renal or liver impairment, bone marrow toxicity gastrointestinal mucosal injury. Intestinal mucositis, bleeding peptic ulcers are well-known effects MTX, although cases fatal necrosis induced by extremely rare. Here, we report case an 82-year-old Japanese woman who...
Oxaliplatin-based chemotherapy plays a central role in the treatment of patients with colorectal liver metastasis (CRLM). This treatment, however, has been associated hepatic sinusoidal obstruction syndrome (SOS), clinically important adverse effect characterized by bluish hue liver, splenomegaly and thrombocytopenia, resulting dysfunction. The significant association between endothelium platelets suggested that oxaliplatin-based affects liver. study compared platelet counts who did not...
The use of staging laparoscopy (SL) has become widespread in patients with advanced gastric cancer (GC). This study aimed to evaluate the predictive value neutrophil/lymphocyte ratio (NLR) for presence peritoneal metastasis during GC. retrospective analysis was performed 35 GC who underwent SL at Kanazawa Medical University Hospital between January 2009 and December 2017. Clinicopathological characteristics were examined multivariate analyses identify preoperative laboratory parameters that...
Abstract Blood vessels are composed of endothelial cells (EC) and mural cells, the interaction between EC is essential for development maintenance vasculature. differentiate from bone marrow‐derived progenitor (EPC). Recently, we established a conditionally immortalized marrow EPC‐derived cell line, TR‐BME2, brain capillary (BCEC) TR‐BBB, temperature‐sensitive‐SV40 T‐antigen gene transgenic rats. To understand function EPC, it important to analyze difference EPC mature such as BCEC. In this...
Abstract Background and Aim Sinusoidal obstruction syndrome (SOS) is a serious drug‐induced liver injury. However, the pathophysiology of disease remains unclear. This study investigated effects cilostazol (CZ), phosphodiesterase III inhibitor, in monocrotaline (MCT)‐induced rat model SOS. Methods Male Wistar rats were administrated MCT to induce Rats divided into control, MCT, + CZ groups. In group, was administered at 48 h, 24 30 min prior 8 h after administration. The group treated with...
Oxaliplatin-based chemotherapy plays an important role in the treatment of colorectal liver metastases. Oxaliplatin, however, causes sinusoidal obstruction syndrome (SOS), which is characterized by portal hypertension, splenomegaly, thrombocytopenia, and dysfunction. SOS diagnosed histopathologically disruption endothelium, collagen deposition, fibrosis especially around zone 3, dilatation space congestion. This study assessed characteristics a rat model SOS. was induced rats administration...
Cystic neoplasms of the liver are divided into two types: mucinous cystic neoplasm and intraductal papillary bile duct. We herein report cases which differed from abovementioned types. Case 1. A 70-year-old man. Radiologically, a tumor measuring 20 mm in diameter was found at hepatic hilum. Right hepatectomy performed under diagnosis intrahepatic cholangiocarcinoma (iCCA) based on imaging findings. 2. 60 Under iCCA, left trisectionectomy performed. In both cases, endoscopic retrograde...
Background/Aim: We evaluated whether splenic volume (SV) predicts sinusoidal obstruction syndrome (SOS) in colorectal cancer (CRC) patients receiving capecitabine plus oxaliplatin (CapeOX) therapy. Patients and Methods: In this retrospective study, we measured SV 41 adjuvant CapeOX for CRC at five different time points. compared the clinical data of 18 who experienced ≥30% increases immediately after vs. before (group A) with remaining 23 B). Results: Platelet numbers decreased levels...
A gastric inlet patch (GIP) is an ectopic mucosal lesion usually arising at the cervical esophagus that may rarely cause esophageal adenocarcinoma (EAC). To best of our knowledge, this first case a GIP‑derived EAC was successfully treated using multidisciplinary treatment approach. 64‑year‑old man referred to Department Gastrointestinal Surgery, Kanazawa University Hospital (Kanazawa, Japan) for surgical refractory recurrent derived from GIP who had previously been with induction...
A useful perioperative nutritional therapy for highly invasive esophageal cancer surgical cases needs to be developed. We clarified the usefulness of amino acid-enriched using glutamine (Gln)/arginine (Arg)/calcium β-hydroxy-β-methylbutyrate (HMB) products on short-term postoperative outcomes minimally esophagectomy cancer. Altogether, 114 patients (Gln/Arg/HMB group) received with Gln/Arg/HMB products, and we retrospectively investigated change in parameters including skeletal muscle mass,...
It has previously been suggested that postgastrectomy syndrome (PGS) is more severe in patients after surgery for advanced gastric cancer than with early cancer. Using the assessment scale‑45 (PGSAS‑45), present study aimed to determine whether PGS patients, Kanazawa Medical University Hospital, was A questionnaire survey conducted using PGSAS‑45 curative gastrectomy cases at Hospital. The data were combined patient background data, anonymized and moved an unlinked file privacy. this...
Gallbladder torsion is a rare and potentially fatal condition presenting with acute abdominal pain. requires early diagnosis treatment; however, preoperative difficult. In the present case, magnetic resonance cholangiopancreatography provided definitive imaging findings was very useful in making diagnosis.
Abstract Background Conversion surgery (CS) following a response to chemotherapy occasionally leads prolonged survival in patients with stage IV gastric cancer (GC). This study aimed evaluate the predictive value of neutrophil/lymphocyte ratio (NLR) for success CS GC. Methods We retrospectively analyzed data 50 GC who received systemic between January 2009 and December 2017 at Kanazawa Medical University Hospital. The successful group included underwent R0 or R1 resection CS, failed did not...
Background/Aim: A significant predictive factor for the occurrence of complications after gastrectomy in elderly gastric cancer patients is yet to be determined. We aimed evaluate clinical factors associated with overall including remote infection patients. Patients and Methods: retrospectively analyzed data 101 aged over 80 years, who underwent curative gastrectomy. clinicopathological that were independently or by a logistic regression model. Results: The complication rate was 24.8%....