A5018007136- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Immune cells in cancer
- Cancer Cells and Metastasis
- Intraperitoneal and Appendiceal Malignancies
- Neuroendocrine Tumor Research Advances
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Diagnosis and Treatment
- Stress Responses and Cortisol
- Cancer, Hypoxia, and Metabolism
- Assisted Reproductive Technology and Twin Pregnancy
- Intestinal Malrotation and Obstruction Disorders
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
Ishikawa Prefectural Central Hospital
2023-2025
Kanazawa University
2015-2024
Hokkaido University Hospital
2024
Kanazawa University Hospital
2017-2023
Kanazawa Medical Center
2015-2022
National Hospital Organization
2015-2022
Toyama Prefectural Central Hospital
2020
Osaka International Cancer Institute
2018
Gangnam Severance Hospital
2018
Yonsei University
2018
Tumor-associated macrophages (TAMs) of the M2 phenotype are known to promote tumor proliferation and be associated with a poor prognosis in numerous cancers. Here, we investigated whether participate development peritoneal dissemination gastric cancer.The characteristics cancer patients or without were examined by flow cytometry real-time quantitative polymerase chain reaction. The effects on phenotypic changes cell line MKN45 assessed direct indirect co-culture system vitro an vivo mouse...
The lipid scavenger receptor cluster of differentiation 36 (CD36) has been shown to have a pro-metastatic function in several cancers. Adipose tissue, favorable site for peritoneal metastasis (PM) from gastric cancer (GC), promotes this process by providing free fatty acids (FFAs); however, the role CD36 PM progression GC remains be elucidated.We evaluated expression cells under various conditions. overexpressing (CD36OE) MKN45 were prepared and their migration invasive properties assessed....
The role of tumor-stroma interactions in tumor immune microenvironment (TME) is attracting attention. We have previously reported that cancer-associated fibroblasts (CAFs) contribute to the progression peritoneal metastasis (PM) gastric cancer (GC), and M2 macrophages mast cells also TME PM. To elucidate CAFs TME, we established an immunocompetent mouse PM model with fibrosis, which reflects clinical features TME. However, involvement immunosuppressive remains unclear. In this study,...
In this study, the effects of neoadjuvant chemotherapy (NAC) on cancer-associated fibroblasts (CAFs) in pancreatic cancer stroma were investigated.Density α-smooth muscle actin (αSMA)-positive resected surgical specimens from untreated patients, patients receiving conventional gemcitabine plus S-1 (GS), and nab-paclitaxel (GnP) was determined by hybrid cell counting. 18F-Fluorodeoxyglucose positron-emission tomography (FDG-PET) scans carbohydrate antigen 19-9 (CA19-9) concentrations used to...
Scirrhous gastric cancer is an intractable disease with a high incidence of peritoneal dissemination and obstructive symptoms (e.g., ileus, jaundice, hydronephrosis) arising from accompanying marked fibrosis. Microenvironmental interactions between cells cancer-associated fibroblasts are the suggested cause disease. We elucidated mechanisms tumor growth fibrosis using human mesothelial (HPMCs) investigated effects tranilast treatment on xenograft mouse model fibrosis.HPMCs were isolated...
Background/Aim: Severe sepsis is associated with high morbidity and mortality rates. Inflammation coagulation play pivotal roles in the pathogenesis of leading to multiple organ failure, especially liver. The aim present study was assess mechanism from liver damage a mouse model. Materials Methods: We created model by injecting lipopolysaccharide (LPS) intraperitoneally mice. At 0, 6, 12, 24 h following intraperitoneal injection LPS, mice were euthanised analyzed. Primary antibodies against...
Abstract Background Peritoneal metastasis (PM) is one of the most common causes noncurative surgery and frequent recurrence pattern in gastric cancer (GC). During process PM, GC cells detached from primary tumor interact with human peritoneal mesothelial (HPMC) overlapped adipose tissues such as omentum or mesentery. Although interaction HPMC promotes malignancy GC, role remains unclear. Aims We aimed to clarify how tissue are affected by adjacent tumors during expression adipokines...
Background The optimal reconstruction route after esophagectomy remains controversial. retrosternal has the advantage of a lower risk fatal complications. However, blind maneuver to create may cause bleeding and pleural injury. Herein, we report novel robotic technique for creating route.
Platelets are one factor promoting tumor development. Conversely, lymphocytes for immune protection. The peripheral blood platelets-lymphocyte ratio (PLR) is useful as an inflammation/immune indicator to predict postoperative recurrence and prognosis of a variety malignancies. neutrophil-lymphocyte (NLR) has also been reported indicator. However, there few studies evaluating the relationship between these indicators effectiveness chemotherapy. Thus, we examined relationships in gastric...
Sevelamer is an anion exchange resin used to treat hyperphosphatemia. A common adverse effect of sevelamer constipation. According a review the available literature, colon perforation associated with this agent was less common.A 66-year-old man complaining lower abdominal pain transferred our hospital. The patient had been undergoing hemodialysis for chronic renal failure due rapidly progressive glomerulonephritis, and receiving hydrochloride 4.5 g/day 8years as treatment Abdominal computed...
Background/Aim: Anastomotic leakage is one of the most common and serious postoperative complications following esophagectomy. This study analyzed effect risk factors, such as degree arteriosclerosis, comorbidities, patient characteristics on incidence reconstruction-related including anastomotic leakage. Furthermore, usefulness tailor-made reconstruction methods was clarified using wide gastric conduit. Patients Methods: who underwent esophagectomy with a conduit for esophageal cancer...
Abstract Background X‐linked dystrophin‐deficient muscular dystrophy (MD) is a form of MD caused by variants in the DMD gene. It fatal disease characterized progressive weakness and degeneration skeletal muscles. Hypothesis/Objectives Identify deleterious genetic whole‐genome sequencing (WGS) using next‐generation sequencer. Animals One MD‐affected cat, its parents, 354 cats from breeding colony. Methods We compared WGS data affected cat with available National Center for Biotechnology...
Abstract Objectives Interleukin-17A (IL-17A) is pro-inflammatory cytokine and acts as profibrotic factor in the fibrosis of various organs. Fibrosis tumor-like peritoneal dissemination gastric cancer interferes with drug delivery immune cell infiltration because its high internal pressure. In this study, we examined relationship between IL-17A tissue elucidated mechanism induced by using human mesothelial cells (HPMCs) a mouse xenograft model. Methods Seventy patients were evaluated. The...
Abstract Background Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cells accompanied extensive stromal fibrosis the peritoneal space. The prognosis of GC with PM still poor regardless various current treatments. In order to elucidate cause difficulties treatment, we compared tumor immune microenvironment (TME) primary lesions GC. addition, a model fibrous stroma was constructed using immunocompetent mice determine whether its...
To clarify the mechanisms of formation peritoneal dissemination, a new animal model by i.p. inoculation highly metastatic gastric cancer cell line MKN-45-P was developed. Peritoneal dissemination with bloody ascites found in 100% nude mice, injected 1x10(7) cells suspension into cavity. By sensitive method for specific detection metastasized human tumor mice using polymerase chain reaction, beta-globin-related sequence DNA from various parts peritoneum specifically amplified and detected gel...
Extravasated platelet aggregation (EPA) serves an important role in the cancer microenvironment during progression, and has been demonstrated to interact with tumor cells several types of cancer. EPA induces epithelial-mesenchymal transition (EMT) via transforming growth factor-β, also recruits immunosuppressive cells, including regulatory T (Treg) myeloid-derived suppressor (MDSCs). However, gastric peritoneal metastasis remains unknown. The present study analyzed association between...
Postoperative pancreatic fistula (POPF) after pancreatoduodenectomy greatly influences patients' postoperative course. Several evaluation methods have been used to assess the risk of clinically relevant POPF (CR-POPF) namely, original, alternative, and updated alternative scores (o-FRS, a-FRS, ua-FRS, respectively). We enrolled 106/179 patients who underwent in our institution between April 2013 Mar 2018. CR-POPF was defined as grade B C according 2016 definitions International Study Group...
The theory of extravasated platelet aggregation in cancer lesions was recently introduced. We investigated the association gastric stroma with clinicopathological features, chemotherapeutic response, pathological and survival.The study comprised 78 patients advanced who had undergone gastrectomy or without combination docetaxel, cisplatin S-1 (DCS) as preoperative chemotherapy between 2005 2014. were divided into two groups: received DCS therapy forming p-DCS group not control group. 39...
The degree of difficulty in the overall procedure and forceps handling encountered by surgeons is greatly influenced positional relationship intrathoracic organs minimally invasive esophagectomy. This study aimed to identify anatomical factors associated with esophagectomy assessed intraoperative injuries postoperative outcomes.Minimally left-decubitus position was performed 258 patients. We defined α (mm) as anteroposterior distance between front vertebral body aorta, β center γ (degree)...
The earliest event in the formation of peritoneal dissemination is considered through process attachment intraperitoneal free cancer cells to submesothelial basement membrane, exposed after contraction mesothelial cells. We studied mechanisms using a. highly metastatic sell line (MKN-45-P) peritoneum. Four hours inoculation MKN-45-P, mouse began contract, and membrane was widely 24 h. same changes developed four i.p. injection IL-6, TNF-alpha IL-8, were most prominently observed mice treated...