A5045905510- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Immune Response and Inflammation
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Immune Cell Function and Interaction
- Inflammatory Biomarkers in Disease Prognosis
- Immune cells in cancer
- Sepsis Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Immunotherapy and Immune Responses
- Colorectal and Anal Carcinomas
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
- Gastrointestinal disorders and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Inflammasome and immune disorders
- Helicobacter pylori-related gastroenterology studies
National Defense Medical College
2016-2025
National Defense Medical College Hospital
2006-2024
Japan Surgical Society
2023
Fukushima Medical University
2013
Kagoshima University
2013
University of Florida
2004-2006
Florida College
2004-2006
Foundation for Ichthyosis and Related Skin Types
2006
Complicated gastric lymphatic drainage potentially undermines the utility of sentinel node (SN) biopsy in patients with cancer. Encouraged by several favorable single-institution reports, we conducted a multicenter, single-arm, phase II study SN mapping that used standardized dual tracer endoscopic injection technique.Patients previously untreated cT1 or cT2 adenocarcinomas < 4 cm gross diameter were eligible for inclusion this study. was performed using technique. Following identified SNs,...
Abstract CD 47 is an antiphagocytic molecule that acts via ligation to signal regulatory protein alpha on phagocytes; its enhanced expression and therapeutic targeting have recently been reported for several malignancies. However, in gastric cancer not well documented. Immunohistochemical of surgical specimens was investigated. Expression 44, a known stem cell marker, were investigated lines by flow cytometry. MKN 45 74 cells sorted fluorescence‐activated sorting according 44 levels, their...
Abstract Photothermal therapy (PTT) using a photo-absorbent in the near-infrared (NIR) region is an effective methodology for local cancer treatment. Before PTT NIR absorbent executed, operator generally determines two parameters of fluence rate and irradiation time. However, even if are unchanged, therapeutic effect often different individual tumors. Hence, we examined (ICG lactosome) while changing (fluence time) various combinations. As result, there was no robust correlation between...
Abstract Background Tumor size (TS) in pancreatic ductal adenocarcinoma (PDAC) is one of the most important prognostic factors. However, discrepancies between TS on preoperative images (TSi) and pathological specimens (TSp) have been reported. This study aims to evaluate factors associated with differences TSi TSp. Patients Methods We retrospectively analyzed patients PDAC who underwent surgery at our institution January 2010 November 2023. discrepancy (TSD[%]) was defined as ([TSp −...
Highly activated neutrophils play a critical role in mediating organ injury sepsis by releasing neutrophil elastase (NE). Toll-like receptors (TLRs) an important the host defense against invading microbes, and their signaling pathway is to activation of proinflammatory response. However, relationship between TLR expression mechanism during has not been fully elucidated. In this paper, we investigated relationships among chemokine (MIP-2), TLR-4, NE human murine peritonitis (CLP). TLR-4 on...
Helicobacter pylori is reportedly involved in the development of gastric cancer. We investigated mechanisms by which H. affects cancer growth and antitumor immunities host, focusing on pylori-derived lipopolysaccharide (LPS).H. four cell lines (MKN28, MKN45, NUGC3, KATOIII) were used. examined effect or its LPS stimulation involvement LPS-toll-like receptor 4 (TLR4) pathway. also cytotoxicities pylori/LPS-stimulated human mononuclear cells (MNC) against cytokine production MNC.H. pylori, as...
In Brief Objective: To evaluate the early results of sentinel node (SN)-navigated limited surgery for gastric cancer. Summary Background Data: False-negative SN biopsy cannot be ignored in cancer surgery. Previous studies suggest that dissection lymph stations where SNs belong (SN stations) may minimize possibility leaving metastasis behind SN-navigated Methods: Patients with T1N0M0 <4 cm were informed about from 2003 to 2008. identified using radioisotope and dye methods. When by frozen...
Highly accurate risk assessment of recurrence may improve adjuvant treatment practice in stage II colorectal cancer (CRC), which lacks definite prognostic factors. Recent studies indicate the importance stroma determining behavior, although there are few histopathologic criteria for its evaluation. A pathology review 679 CRC patients (1980-2005) was conducted at an institution. Desmoplastic reaction (DR) results were classified as mature, intermediate, or immature depending on presence...
This study was performed to evaluate the oncological impact of surgical site infection (SSI) and pneumonia on long-term outcomes after esophagectomy.
Abstract Background Neutrophil extracellular traps (NETs) have been implicated in cancer progression by enhancing cell motility through the coiled-coil domain-containing protein 25 (CCDC25). Objective This study aimed to evaluate prognostic value of CCDC25 expression patients with esophageal squamous carcinoma (ESCC). Method Tissue specimens from who underwent radical esophagectomy for ESCC were analyzed investigate relationship between expression, clinicopathological features, and...