A5003158111- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Genetic and Kidney Cyst Diseases
- Renal Diseases and Glomerulopathies
- Liver physiology and pathology
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
- MRI in cancer diagnosis
- Hepatitis B Virus Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Liver Diseases and Immunity
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Trace Elements in Health
- Ovarian cancer diagnosis and treatment
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- Tuberous Sclerosis Complex Research
- Gastrointestinal Tumor Research and Treatment
Teikyo University
2012-2021
Teikyo University Hospital
2014-2020
Rush University Medical Center
2017
Columbia College - Missouri
2017
Toranomon Hospital
2017
Funabashi Central Hospital
2001-2015
Chiba East Hospital
2014
Shizuoka Institute of Science and Technology
2014
Vanderbilt University Medical Center
2009
Chiba University
1999-2008
Primary liver carcinomas with both hepatocytic and cholangiocytic differentiation have been referred to as "combined (or mixed) hepatocellular‐cholangiocarcinoma." These tumors, although described over 100 years ago, attracted greater attention recently because of interest in possible stem cell origin perhaps frequency clinical recognition. Currently, a lack common terminology the literature, effective treatment predictable outcome data challenging accrue. This article represents consensus...
Abstract Percutaneous ethanol injection (PEI) was applied to 120 lesions in 95 patients with hepatocellular carcinomas (HCC) smaller than 3 cm the past 6 years. All main target tumours, 67 who had been followed by sonography for more months after PEI, decreased size; 28 tumours (41.8%) became undetectable and have remained so until now. The 1‐, 2‐, 3‐, 4‐ 5‐year survival rates calculated Kaplan‐Meier method were 93%, 81%, 65%, 52% 28% respectively. These better those of HCC did not receive...
Recently the authors proposed a new staging and grading system for primary biliary cirrhosis (PBC) that takes into account necroinflammatory activity histological heterogeneity. Herein is convenient version of this system. Scores fibrosis, bile duct loss, chronic cholestasis were combined staging: stage 1, total score 0; 2, 1–3; 3, 4–6; 4, 7–9. Cholangitis (CA) hepatitis (HA) graded as CA0–3, HA0–3, respectively. Analysis interobserver agreement was then conducted. Digital images 62 needle...
Magnetic resonance (MR) images of the liver were used to study 43 patients with relatively small hepatocellular carcinomas (HCCs) and 36 other hepatic mass lesions. In 27 HCC patients, histologic findings available. All focal lesions detectable by CT without contrast media delineated greater MR imaging. The rate detection depended on tumor size, being 97.5% for HCCs than 2 cm in longest axis 33.3% those less cm. imaging demonstrated ring sign characteristic encapsulated twice as frequently...
Abstract Background The aim of this study was to determine the clinicopathological features and surgical outcomes mucinous cystic neoplasm liver ( MCN ) mucin‐producing intraductal papillary intrahepatic bile duct M ‐ IPNB ). Methods We performed a multi‐institutional, retrospective patients with or pathologically defined by presence absence an ovarian‐like stroma. Results were diagnosed in 119 nine patients, respectively. observed female while produced symptoms cholangitis. IPNBs classed as...
Although recent findings of cancer biology research indicate that prognostic power arises from genes expressed by stromal cells rather than epithelial cells, desmoplastic reaction (DR) has not been completely examined as a marker for colorectal cancer. A pathologic review 821 stage II and III patients who underwent R0 resection at 4 independent institutions was conducted. DR classified mature, intermediate, or immature based on the existence hyalinized keloid-like collagen myxoid stroma...
Nodular hepatic lesions detected in 123 patients with chronic liver diseases were subjected to ultrasonically guided needle biopsy. Of these, 94 cases diagnosed as hepatocellular carcinoma of a moderately or poorly differentiated type classical histologic features carcinoma. In 14 whom hepatocytes had minimal atypical changes and mostly normotrabecular arrangement (one two cells thick), diagnosis well-differentiated was made on the basis following three criteria: nuclear crowding, increased...
Abstract BACKGROUND. Stromal invasion is 1 of the main features used to distinguish high‐grade dysplastic nodules (DNs) from well‐differentiated hepatocellular carcinomas (HCCs). The authors hypothesized that ductular reaction (DR) takes place around noninvasive but not within stroma contiguous invasive HCC. METHODS. DR/cytokeratin 7 (CK7)‐positive patterns were evaluated in 105 resected small hepatic according level invasion. classified histologically prior immunostaining as (large...
In order to reveal the precursor lesion of hepatocellular carcinoma, a histopathologic study was performed on 141 cases liver cirrhosis with or without carcinoma. Exclusive primary metastatic carcinoma nodules, 94 nodular lesions (greater than 5 mm) were detected in 53 cirrhotic livers. They consisted 83 large regenerative nodules and 11 dysplastic nodules. Besides some common features those observed former type, presented increased cytoplasmic basophilia, nuclear nucleolar enlargement,...
PURPOSE: To investigate the relationship between metal content of hepatocellular carcinoma (HCC) and signal intensity pattern on magnetic resonance images. MATERIALS AND METHODS: The patterns 59 HCCs 3 cm in diameter or smaller were correlated with histologic findings content. RESULTS: high T1-weighted images demonstrated more steatosis (P = .035) higher copper .008) than did surrounding hepatic parenchyma. T2-weighted clear cells .001) intensities related to a lower degree differentiation,...
Biliary lining epithelia of the bile ducts in biliary diseases are known to have intraepithelial atypical/proliferative lesions related development cholangiocarcinoma. The purpose present study was determine histological criteria for these based on interobserver agreement. Digital images 30 stone‐containing intrahepatic hepatolithiasis (30 cases) were sent 10 pathologists. At first, pathologists made a diagnosis (either reactive/regenerative change, low‐grade or high‐grade neoplasia (BilIN‐1...
To evaluate the therapeutic effect of percutaneous ethanol injection (PEI) on small hepatocellular carcinoma (HCC) with computed tomography (CT).Sixty-seven patients histologically proved HCC 3 cm or less in diameter underwent PEI. The were regularly followed up sonography and contrast material-enhanced CT for more than 1 year (range, 12-96 months). findings evaluated three tumor types distinguished basis their appearance relative to that surrounding liver parenchyma: type = hyperattenuating...
Seventeen patients with cirrhosis and histologically defined, ultrasonically detected, large regenerative nodules of the liver were followed without treatment for more than 1 yr (range = 13 to 51 mo). During follow-up period, none demonstrated sonographically have enlarged. Computed tomography and/or hepatic angiography also performed in 14 patients, but there was no evidence malignant transformation these lesions. None 17 showed acute elevation serum α-fetoprotein levels. Furthermore, four...
Some follow-up studies of large regenerative nodules (LRNs) and dysplastic (DNs) were reported previously. However, the pre-malignant potentiality LRNs has remained controversial up to now. No showed malignant transformation in our previous study. We aimed evaluate DNs with a greater number cases longer periods. From 1982 2005, 1,500 consecutive nodular lesions 2 cm diameter subjected US guided thin-needle biopsy cirrhotic patients at Chiba University Hospital. Of these lesions, 68 60 20 22...
We report a 69-year-old female patient with advanced lung cancer who developed myocarditis concomitant myasthenia gravis (MG), also known as "Herzmyasthenie," after 3 cycles of nivolumab administration. Her initial symptoms were general malaise and double vision. However, her deteriorated rapidly the following day, necessitating temporary pacemaker noninvasive positive pressure ventilation in intensive care unit. Immunohistochemical examination myocardial biopsy suggested an immune response...
Highly accurate risk assessment of recurrence may improve adjuvant treatment practice in stage II colorectal cancer (CRC), which lacks definite prognostic factors. Recent studies indicate the importance stroma determining behavior, although there are few histopathologic criteria for its evaluation. A pathology review 679 CRC patients (1980-2005) was conducted at an institution. Desmoplastic reaction (DR) results were classified as mature, intermediate, or immature depending on presence...
Abstract Purpose: Recently, the application of replication-competent viruses has been studied as anticancer agents. Sindbis virus (SIN) is an RNA that belongs to Alphavirus genus in Togaviridae family. The AR339 strain SIN not reported induce any serious disease humans. Experimental Design: In this study, we evaluated feasibility agent for cervical and ovarian cancer therapy. Results: infection was able cytopathic effects apoptosis two cells (HeLaS3 C33A) three (HOC-1, HAC-2, OMC-3) but...
Small (less than 5 cm) hepatocellular carcinomas (HCCs) in 45 of 112 patients (40.2%) had a high-signal-intensity pattern (relative to that liver) on T1-weighted magnetic resonance (MR) images. To identify the cause this pattern, specimens histologically defined HCC with high- (n = 21), iso- 6), and low- 22) intensity patterns were evaluated for paramagnetic ionic forms metals. The incidence steatosis, clear cell formation, copper accumulation was statistically (P less .01) higher tumors...