A5003857077- Immune Response and Inflammation
- Exercise and Physiological Responses
- Immune cells in cancer
- Immune Cell Function and Interaction
- Wound Healing and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cardiac Arrest and Resuscitation
- Polymer Surface Interaction Studies
- Autopsy Techniques and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Traumatic Brain Injury and Neurovascular Disturbances
- Cancer Immunotherapy and Biomarkers
- Surgical Sutures and Adhesives
- Nanoplatforms for cancer theranostics
- Inflammasome and immune disorders
- Adipose Tissue and Metabolism
- Radar Systems and Signal Processing
- Traumatic Ocular and Foreign Body Injuries
- Parathyroid Disorders and Treatments
- Cardiovascular and exercise physiology
- Advanced Algorithms and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Traumatic Brain Injury Research
- Lipid metabolism and biosynthesis
- Antimicrobial agents and applications
National Defense Medical College
2016-2025
Uji Hospital
2020-2023
Electronic Navigation Research Institute
2017
Kumamoto University
2017
Smith College
2016
Syracuse University
2016
University of Memphis
2016
Texas A&M University
2016
John Wiley & Sons (United States)
2016
National Defense Medical College Hospital
2011-2013
ABSTRACT Although mouse liver F4/80+ Kupffer cells consist of cytokine-producing CD11b+ and phagocytic CD68+ cells, an undefined CD11b− CD68− subset (30%) also exists. We herein demonstrate a more fundamental classification by adding CD32 (FcγRII), which covers most the distinct functions them. Among 50%, 40%, 30% were CD32+, CD68+, CD11b+, respectively, one-half coexpressed CD32. CD32+ but not expressed phagocytosis-related CRIg. Gy (6) irradiation depleted those in spleen, bone marrow,...
Nelumbo nucifera Gaertn. (Nymphaceae) has been used for various medicinal purposes as in Chinese herbal medicine. In particular, the leaves are known diuretic and astringent properties, to treat obesity. During our search a plant-derived anti-obesity agent from natural products, we have found that 50% ethanol (EtOH) extract prepared of N. (NN) stimulated lipolysis white adipose tissue (WAT) mice beta-adrenergic receptor (beta-AR) pathway was involved this effect. subsequent experiments,...
ABSTRACT Bacterial infections, including surgical site infections (SSI), are a common and serious complication of diabetes. Staphylococcus aureus , which is eliminated mainly by neutrophils, major cause SSI in diabetic patients. However, the precise mechanisms diabetes predisposes to staphylococcal infection not fully elucidated. The effect insulin on this also well understood. We therefore investigated treatment neutrophil function mice. S. was inoculated into abdominal muscle db /...
Autologous split-thickness skin grafts are the preferred treatment for excised burn wounds, but donor sites autografting often limited in patients with extensive burns. A number of alternative treatments already use to treat large burns and ulcers. Despite intense efforts develop tissue-engineered skin, delayed or absent vascularization is one major reasons engraftment failure. To overcome these problems, we developed a scaffold-free 3-dimensional (3D) substitute containing vascular networks...
Freestanding poly(L-lactic acid) (PLLA) nanosheets are mass-produced by a simple combination of spin-coating-assisted multi-layering process and peeling technique. The resulting PLLA fragmented homogenization then reconstructed into "patchwork" sheet on various surfaces without any adhesive reagents. patchwork is shown to offer excellent protection against burn wound infection with Pseudomonas aeruginosa, may therefore be an alternative conventional therapy for prevention infection.
Nanostructuring surfaces is an emergent strategy to endow materials with abilities combat pathogenic bacteria. Nevertheless, it remains challenging create nanospike structures on the curved of polymer materials, including gauze and other microfibrous medical materials. Additionally, effects nanostructured bacteria in presence proteins vivo remain largely unexplored. Herein, we demonstrated decoration microfiber via self-assembly cello-oligosaccharides investigated nanospiked proteins. The...
ABSTRACT Although B cells in vertebrates have been thought to lack phagocytic activity, there has a recent report of such ability by the early as fish and frogs. Here, we show for first time that mouse liver IgM+ actively phagocytose microsphere beads Escherichia coli they effectively kill bacterial cells. Such activity is not observed other MNCs, except F4/80+ Kupffer In presence fresh serum (but heat-inactivated serum), heat-killed E. increased significantly but was inhibited...
Although there have been multiple advances in the development of novel anticancer agents and operative procedures, prognosis patients with advanced gastric cancer remains poor, especially peritoneal metastasis. In this study, we established nanoparticles loaded indocyanine green ( ICG ) derivatives: lactosomes m) investigated diagnostic therapeutic value photodynamic therapy PDT using m for experimental dissemination cancer. Experimental disseminated xenografts human were nude mice. Three...
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) infection is a grave concern in burn-injured patients. We investigated the efficacy of interleukin-18 (IL-18) treatment postburn MRSA infection. Alternate-day injections IL-18 into C57BL/6 mice significantly increased their survival after and methicillin-sensitive S. Although augmented natural IgM production before gamma interferon (IFN-γ) infection, neither nor IFN-γ contributed to improvement mouse survival. increased/restored...
Abstract Burn wounds are highly susceptible to bacterial infection due impairment of the skin's integrity. Therefore, prevention colonization/infection in wound is crucial for management burns, including partial‐thickness burn injuries. Although injuries still retain potential reepithelialization, complication severely impairs reepithelialization even such superficial We recently developed a biocompatible nanosheet consisting poly( l ‐lactic acid) ( PLLA ). The nanosheets have many useful...
Abstract We have recently reported that Kupffer cells consist of two subsets, radio-resistant resident CD68+ and radio-sensitive recruited CD11b+ cells/macrophages (Mφs). Non-alcoholic steatohepatitis (NASH) is characterized not only by hepatic steatosis but also chronic inflammation fibrosis. In the present study, we investigated immunological mechanism diet-induced in fibroblast growth factor 5 (FGF5) deficient mice. After consumption a high fat diet (HFD) for 8 weeks, FGF5 null mice...
The purpose of the present study was to investigate effects swimming training on changes in three superoxide dismutase (SOD) isoenzymes mice. trained mice underwent a 6-wk program (1 h/day, 5 days/wk) water at 35–36°C. Immunoreactive extracellular SOD (EC-SOD), copper- and zinc-containing (CuZn-SOD), manganese-containing (Mn-SOD) contents their mRNA abundance were determined serum, heart, lung, liver, kidney, gastrocnemius muscle. EC-SOD content liver kidney significantly increased with...
Postmenopausal women as well rodents after ovariectomy, which results in a lack of estrogen, can become obese. Ovariectomy-induced obesity mice is associated with decrease oxygen consumption, indicating repressed energy expenditure. In this study, to elucidate the mechanism weight gain we examined expression patterns genes related expenditure and lipid metabolism, mouse tissues including adipose tissue skeletal muscle. muscle, at 2-4 wk levels nuclear receptors cofactors involved such ERR1,...