A5101870911- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Neuropeptides and Animal Physiology
- Exercise and Physiological Responses
- Sleep and Wakefulness Research
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Biochemical effects in animals
- Receptor Mechanisms and Signaling
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Circadian rhythm and melatonin
- Neuroendocrine regulation and behavior
- Sports Performance and Training
- Thermoregulation and physiological responses
- Stress Responses and Cortisol
- Hydrogen's biological and therapeutic effects
- Physical Education and Training Studies
- Cardiovascular Disease and Adiposity
- Boron Compounds in Chemistry
- Amoebic Infections and Treatments
Shigakkan University
2015-2021
University of Miyazaki
2010-2020
Miyazaki Welfare Medical College
2001-2005
University of Tsukuba
1996-2003
Suntory (Japan)
2003
National Cerebral and Cardiovascular Center
2003
Tokyo Medical University
2001
University of Copenhagen
2001
Kyorin University
2001
Dongguk University
1999-2001
The hypothalamus regulates energy intake by integrating the degree of starvation or satiation with status environment through a variety neuronal and blood-derived signals. Ghrelin, peptide produced in stomach hypothalamus, stimulates feeding GH secretion. Centrally administered ghrelin exerts an orexigenic activity neuropeptide Y (NPY) agouti-related protein systems. interaction between other hypothalamic peptides, however, has not been clarified. Here, we investigated anatomical...
Abstract Peptide YY (PYY), an anorectic peptide, is secreted postprandially from the distal gastrointestinal tract. PYY3–36, major form of circulating PYY, binds to hypothalamic neuropeptide Y Y2 receptor (Y2-R) with a high-affinity, reducing food intake in rodents and humans. Additional hormones involved feeding, including cholecystokinin, glucagon-like peptide 1, ghrelin, transmit satiety or hunger signals brain via vagal afferent nerve and/or blood stream. Here we determined role vagus...
Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and GH secretion via interactions with secretagogue type 1a receptor (GHS-R1a), functionally active form of GHS-R. Ghrelin molecules exist stomach hypothalamus as two major endogenous forms, a at serine 3 (ghrelin) des-acylated (des-acyl ghrelin). Acylation is indispensable for binding ghrelin to GHS-R1a. enhances neuronal pathways neuropeptide Y orexin, which act orexigenic peptides hypothalamus. We here...
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus, resulting obesity and diabetes. The vagus nerve connects visceral central nervous system, gastric-derived orexigenic peptide ghrelin transmits its starvation signals to hypothalamus via vagal afferent nerve. Here we investigated inflammatory response neurons mice following one day of HFD feeding. This treatment increased number macrophages/microglia nodose ganglion hypothalamus. Furthermore, one-day...
Ghrelin and cholecystokinin (CCK) are gastrointestinal hormones regulating feeding. Both transmitted via the vagal afferent, ghrelin elicits starvation signals, whereas CCK induces satiety signals. We investigated interaction between functioning in short-term regulation of feeding Otsuka Long-Evans Tokushima fatty (OLETF) rats, which have a disrupted type A receptor (CCK-AR), their lean littermates, (LETO) rats. Intravenous administration increased 2-h food intake both OLETF LETO Because...
Ghrelin, an acylated peptide serving as endogenous ligand for GH secretagogue receptor (GHS-R), was originally isolated from rat and human stomach. In this study, we report the critical role of maternal ghrelin in fetal development. High levels (GHS-R) mRNA were detected various peripheral tissues beginning at embryonic d 14 lasting until birth. Fetal GHS-R expression also confirmed by immunohistochemistry. Autoradiography revealed that both des-acyl acyl bind to tissues. Chronic treatment...
Ghrelin, a stomach-derived orexigenic peptide, transmits starvation signals to the hypothalamus via vagus afferent nerve. Peripheral administration of ghrelin does not induce food intake in high fat diet (HFD)-induced obese mice. We investigated whether this resistance was caused by dysfunction pathway. Administration (s.c.) did intake, suppression oxygen consumption, electrical activity vagal nerve, phosphorylation ERK2 and AMP-activated protein kinase alpha nodose ganglion, or Fos...
Central insulin action activates hepatic IL-6/STAT3 signaling, which suppresses the gene expression of gluconeogenic enzymes. The vagus nerve plays an important role in this centrally mediated response; however, precise mechanism underlying brain-liver interaction is unclear. Here, we present our findings that signaling via α7-nicotinic acetylcholine receptors (α7-nAchR) on Kupffer cells, and central by suppressing vagal activity. Indeed, insulin-mediated activation suppression were impeded...
Neuropeptide W (NPW) is a novel hypothalamic peptide that activates the previously described orphan G protein-coupled receptors, GPR7 and GPR8. Two endogenous molecular forms of NPW consist 23- 30-amino acid residues were identified. The localization GPR8 in some regions primary importance regulation feeding behavior has provided springboard for investigation role central nervous system. In this study we examined effects on energy expenditure rats. Single intracerebroventricular (i.c.v.)...
Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and growth hormone (GH) secretion via interaction with GH secretagogue receptor. Ghrelin molecules are present two major endogenous forms, form (ghrelin) a des-acylated (des-acyl ghrelin). Recent studies indicated that aerobic exercise did not change plasma total ghrelin levels, however, dynamics of circulating des-acyl during remains unclear. The purpose this study is to examine effects moderate intensity...
The effects of endurance training and acute exhaustive exercise on plasma levels three superoxide dismutase (SOD) isoenzymes the ability generation in neutrophils were studied. Eighteen healthy male students, aged 17–22 years, who volunteered for this study, underwent months swimming or running. Before after course, they performed blood samples collected before exercise. significantly increased maximal oxygen uptake (V˙O2max) all subjects. Neither nor affected CuZn-SOD level. Acute training,...
Neuroendocrine regulatory peptide (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein. Vgf −/− mice exhibit dwarfism hypermetabolic rates, suggesting that VGF or VGF-derived peptides play important roles in energy metabolism. Here, we examined the role NERPs central regulation feeding homeostasis. We attempted to identify expressing neurons rats by immunohistochemistry. studied effects intracerebroventricular (icv) administration on feeding, body...
Obestatin is a 23-amino acid peptide, initially isolated from rat stomach as an endogenous ligand for the orphan G-protein-coupled receptor. derived proteolytic cleavage of 117-amino precursor, preproghrelin. Ghrelin increases food intake, body weight, and gastric emptying, whereas obestatin has opposite effects. In this study, we characterized in both human stomach, investigated peptide's effect on feeding behavior. Using reversed-phase high-performance liquid chromatography coupled with...