A5100614398- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Cardiac Ischemia and Reperfusion
- Vitamin C and Antioxidants Research
- Biochemical effects in animals
- Cardiovascular Effects of Exercise
- Coenzyme Q10 studies and effects
- Antioxidant Activity and Oxidative Stress
- Pharmacological Effects and Assays
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Liver Disease Diagnosis and Treatment
- Fatty Acid Research and Health
- Nitric Oxide and Endothelin Effects
- Sirtuins and Resveratrol in Medicine
- Adipokines, Inflammation, and Metabolic Diseases
- Sports Performance and Training
- Renal function and acid-base balance
- Thermoregulation and physiological responses
- Cardiovascular Function and Risk Factors
- Neurological Disease Mechanisms and Treatments
- Spinal Cord Injury Research
- Mitochondrial Function and Pathology
University of Minnesota
2014-2025
Shandong University
2025
Twin Cities Orthopedics
2018-2021
Shanghai First People's Hospital
2020
Cheongju University
2016
University of Minnesota System
2015
Meizhou City People's Hospital
2015
University of Wisconsin–Madison
2003-2014
South China University of Technology
2014
Huazhong University of Science and Technology
2014
Reactive oxygen or nitrogen species (RONS) are produced during exercise due, at least in part, to the activation of xanthine oxidase. When is exhaustive they cause tissue damage; however, may also act as signals inducing specific cellular adaptations exercise. We have tested this hypothesis by studying effects allopurinol‐induced inhibition RONS production on cell signalling pathways rats submitted Exercise caused an mitogen‐activated protein kinases (MAPKs: p38, ERK 1 and 2), which turn...
Reactive oxygen species (ROS) are implicated in the mechanism of biological aging and exercise-induced oxidative damage. The present study examined effect an acute bout exercise on intracellular ROS production, lipid protein peroxidation, GSH status skeletal muscle young adult (8 mo, n = 24) old (24 female Fischer 344 rats. Young rats ran a treadmill at 25 m/min 5% grade until exhaustion (55.4 +/- 2.7 min), whereas 15 (58.0 min). Rate dichlorofluorescin (DCFH) oxidation, indication other...
JI, L. Antioxidant enzyme response to exercise and aging. Med. Sci. Sports Exerc., Vol. 25, No. 2, pp. 225–231, 1993. enzymes play an important role in defending the cells against free radical-mediated oxidative damage. The present investigations, using rats as models, indicate that antioxidant systems undergo significant alteration during aging acute chronic exercise. Hepatic myocardial show a general decline at older age, whereas activity of glutathione-related liver mitochondrial heart...
These experiments examined the influence of exercise intensity and duration on antioxidant enzyme activity in locomotor muscles differing fiber type composition. Nine groups female Sprague-Dawley rats (age 120 days) exercised 4 days/wk a motor-driven treadmill for 10 wk. The impact three levels (low, moderate, high: approximately 55, 65, 75% maximal oxygen consumption, respectively) (30, 60, 90 min/day) was assessed. Sedentary animals served as controls. Oxidative capacity soleus white red...
Two studies were performed to investigate the effects of an acute bout physical exercise on nuclear protein kappaB (NF-kappaB) signaling pathway in rat skeletal muscle. In Study 1, a group rats (n=6) was run treadmill at 25 m/min, 5% grade, for 1 h or until exhaustion (Ex), and compared with second injected two doses pyrrolidine dithiocarbamate (PDTC, 100 mg/kg, i.p.) 24 prior bout. Three additional groups either 8 mg/kg (i.p.) lipopolysaccharide (LPS), mmol/kg t-butylhydroperoxide (tBHP),...
Controversy exists as to the effect of endurance training on myocardial antioxidant enzyme activity. These experiments sought clarify this issue by examining activities in rat ventricular myocardium response different intensities and durations exercise training. Female Fischer-344 rats (120 days old) were assigned either a sedentary control group or one nine groups. Animals exercised motorized treadmill for 10 wk; combinations three (30, 60, 90 min/day), levels intensity (low, moderate,...
It has been hypothesized that sleep deprivation represents an oxidative challenge for the brain and may have a protective role against damage. This study was designed to test this hypothesis by measuring in rats effects of loss on markers stress (oxidant production antioxidant enzyme activities) as well cellular damage (lipid peroxidation protein oxidation).The analyses were performed peripheral tissues (liver skeletal muscle), after short-term (8 hours), long-term (3-14 days), during...
The effects of endurance training on the enzyme activity, protein content, and mRNA abundance Mn CuZn superoxide dismutase (SOD) were studied in various phenotypes rat skeletal muscle. Female Sprague-Dawley rats randomly divided into trained (T, n = 8) untrained (U, groups. Training, consisting treadmill running at 27 m/min 12% grade for 2 h/day, 5 days/wk 10 wk, significantly increased citrate synthase activity ( P < 0.01) type I (soleus), IIa (deep vastus lateralis, DVL), mixed II...
Eccentric contraction (EC) is known to elicit inflammation and damage in skeletal muscle. Proinflammatory cytokine TNF-alpha plays an important role this pathogenesis, but the time course of its response EC regulatory mechanisms involved are not clear. The purpose study twofold: 1) investigate gene expression rat muscle during after acute bout downhill running associated oxidoreductive (redox) changes; 2) examine whether activates ubiquitin-proteolytic pathway resulting necrosis oxidative...
Inhibition of metabolic enzyme activity has been associated with free radical stress in locomotor muscle prolonged or intense exercise. However, it is not known whether such alterations acute exercise skeletal are influenced by fiber type age. Twenty 4-mo-old and twenty 24-mo-old female Fischer-344 rats were divided at random into young exercised (YE; n = 10), old (OE; control (YC; (OC; 10) groups. Animals both YE OE groups ran on a treadmill (10% uphill grade) for 40 min approximately 75%...