A5063578715- Glioma Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Animal Virus Infections Studies
- Exercise and Physiological Responses
- RNA modifications and cancer
- Advanced biosensing and bioanalysis techniques
- Virology and Viral Diseases
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Viral Infections and Immunology Research
- Respiratory Support and Mechanisms
- Viral gastroenteritis research and epidemiology
- Adipose Tissue and Metabolism
- Regulation of Appetite and Obesity
- MicroRNA in disease regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Biology Techniques and Applications
- Rabies epidemiology and control
- Venomous Animal Envenomation and Studies
- Inflammasome and immune disorders
- NF-κB Signaling Pathways
- Bacillus and Francisella bacterial research
- Chromatin Remodeling and Cancer
- Biochemical Analysis and Sensing Techniques
- Immune Response and Inflammation
Zhongnan Hospital of Wuhan University
2021
Wuhan University
2021
Tongji University
2016
Tongji Hospital
2016
China Animal Disease Control Center
2014
Tianjin University of Sport
2009-2010
Eccentric contraction (EC) is known to elicit inflammation and damage in skeletal muscle. Proinflammatory cytokine TNF-alpha plays an important role this pathogenesis, but the time course of its response EC regulatory mechanisms involved are not clear. The purpose study twofold: 1) investigate gene expression rat muscle during after acute bout downhill running associated oxidoreductive (redox) changes; 2) examine whether activates ubiquitin-proteolytic pathway resulting necrosis oxidative...
ABSTRACT Gliomas, the most prevalent primary malignancy of central nervous system, is characterised by its high mortality rates and unfavourable prognosis. Despite extensive research, underlying mechanisms glioma pathogenesis remain elusive. The Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases provided lower‐grade gliomas (LGG) transcriptome related clinical data, which were downloaded separately. It was determined what data differences between two groups based on median...
Abstract LEPTIN (LEP) is a circulating hormone released primarily from white adipocytes and crucial for regulating satiety energy homeostasis in humans animals. Using the CRISPR technology, we created set of Lep mutant rats that carry either null mutations or deletion 14 th Ile (LEP ∆I14 ) mature LEP protein. We examined potential off-target sites (OTS) by whole-genome high-throughput sequencing and/or Sanger-sequencing analysis found no OTS rats. Mature incessantly produced to blood at much...
Glioma is a relatively low aggressive brain tumor. Although the median survival time of patients for lower-grade glioma (LGG) was longer than that glioblastoma, overall still short. Therefore, it urgent to find out more effective molecular prognostic markers. The role Fam20 kinase family in different tumors an emerging research field. However, biological function Fam20C and its value have rarely been reported. This study aimed evaluate as potential marker LGG. A total 761 LGG samples (our...
Inflammation is an important biological process for eliciting immune responses against physiological and pathological stimuli. must be efficiently regulated to ensure homeostasis in the body. Nuclear factor-kappa B (NF-κB) signaling crucial inflammatory responses. Aberrant activation of NF-κB leads development numerous human diseases. In this study, we investigated function chromosome 7 open reading frame 41 (C7ORF41) during inflammation. C7ORF41 was upregulated cells stimulated with tumor...
AT-rich interaction domain 5A (ARID5A) is a member of the ARID family with function that has been linked to autoimmune as well inflammatory diseases. Some members are involved in initiation and progression human cancers. However, ARID5A glioma remains unknown. In this study, expression levels were analyzed using Gene Expression Profiling Interactive Analysis (GEPIA) database. Subsequently, relationship between clinical characteristics patients was evaluated Chinese Glioma Genome Atlas (CGGA)...
Glioma, the most prevalent primary intracranial malignancy among adults, is distinguished by its high morbidity and recurrence rates, posing a considerable threat to patients' quality of life survival prospects. Consequently, pursuit efficacious molecular prognostic markers holds paramount importance. The exploration role KDELR3 kinase family in various neoplastic conditions constitutes an emerging area research. However, biological functions implications brain tumors remain largely...
A dual real-time quantitative polymerase chain reaction assay (drtqPCR) was established to detect and differentiate between Porcine circovirus-2a (PCV-2a) circovirus-2b (PCV-2b). Genotype-specific primer sets probes were designed by using sequence data published for different PCV-2 strains. Specificity sensitivity of the drtqPCR examined isolates with known genotype. Among 367 tissue samples, 44.69% (164/367) positive. From 164 positive 10.98% (18/164), 92.56% (137/164), 3.31% (9/164)...
Eccentric contraction (EC) is known to elicit inflammation and damage in skeletal muscle. Tumor necrosis factor (TNF) a plays an important role this pathogenesis but its EC unclear. PURPOSE: (1) To investigate the gene expression of TNFa rat muscle during after acute bout downhill exercise signaling pathways; (2) examine whether activates ubiquitin-proteolytic pathway resulting damage. METHODS: Female Sprague-Dawley rats (age 3 mo) were randomly divided into five groups (N=6): ran on...