A5042017809- Head and Neck Surgical Oncology
- Sinusitis and nasal conditions
- Metastasis and carcinoma case studies
- Pituitary Gland Disorders and Treatments
- Advanced Statistical Methods and Models
- Gastric Cancer Management and Outcomes
- Statistical Distribution Estimation and Applications
- Statistical Methods and Bayesian Inference
- Lung Cancer Treatments and Mutations
- Statistical Methods and Inference
- Nuclear physics research studies
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bayesian Methods and Mixture Models
- Colorectal Cancer Treatments and Studies
- Oral and Maxillofacial Pathology
- Statistical Mechanics and Entropy
- Cancer Diagnosis and Treatment
- Advanced Statistical Process Monitoring
- Cerebral Venous Sinus Thrombosis
- Silkworms and Sericulture Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Neuroendocrine Tumor Research Advances
- Multiple and Secondary Primary Cancers
Kyushu University
2010-2020
Sakurabashi Watanabe Hospital
2020
Kanazawa Medical University
2012-2020
Showa University
2004-2014
Gifu Prefectural General Medical Center
2013
RIKEN Nishina Center
2013
NTT WEST Osaka Hospital
2011
The Institute of Statistical Mathematics
2003-2009
Osaka University
1966-2006
Gifu Municipal Hospital
2006
A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It identified as CYP11B2, which previously postulated to be pseudogene or less active closely related CYP11B1, the 11 beta-hydroxylase (P-45011 beta) [Mornet, E., Dupont, J., Vitek, A. & White, P. C. (1989) J. Biol. Chem. 264, 20961-20967]. The nucleotide sequence of promoter region P-450C18 is strikingly different that P-45011 beta gene, although sequences their exons are 93% identical....
The mechanism of airway eosinophilia during antigen-induced inflammation was investigated by measurement eosinophil-active cytokines utilizing an eosinophil survival assay. In the first study, 4 patients with allergic rhinitis underwent segmental bronchoprovocation (SBP) low, medium, and high doses ragweed extract instilled into different bronchial subsegments; bronchoalveolar lavage (BAL) fluids were collected from each segment 12 min 48 h after challenge. Eosinophil granule proteins...
<b>Background and study aims: </b>No prospective comparison of endoscopic ultrasonography-guided direct celiac ganglia neurolysis (EUS – CGN) vs. EUS-guided plexus CPN) has been reported. The aim the current was to compare effectiveness EUS CGN CPN in providing pain relief from upper abdominal cancer a multicenter randomized controlled trial. <b>Patients methods: </b>Patients with were randomly assigned treatment using either or CPN. Evaluation performed at Day 7 postoperatively scale 0 10....
Summary Background Tiotropium bromide, a long acting muscarinic receptor inhibitor, is potent agent for patients with bronchial asthma as well chronic obstructive pulmonary disease. Objective The aim of this study was to evaluate whether tiotropium bromide can inhibit allergen‐induced acute and airway inflammation, T helper (Th)2 cytokine production, remodelling in murine model asthma. Methods Balb/c mice were sensitized challenged acutely or chronically ovalbumin (OVA). impact assessed...
Cucumisin is a thermostable alkaline serine protease that found in the juice of melon fruits (Cucumis melo L.).We have determined complete nucleotide sequence cucumisin cDNA (2,552 nucleotides) and deduced corresponding amino acid sequence.The open reading frame consists 731 codons encodes large precursor (molecular weight, 78,815) relative to observed size mature native (67 ma).Sequence comparisons reveal has several features common with microbial proteases subtilisin family.The highly...
A novel trypsin-like protease was purified to homogeneity from the sputum of patients with chronic airway diseases, by sequential chromatographic procedures. The enzyme migrated on SDS-polyacrylamide gel electrophoresis a position corresponding molecular weight 28 kDa under both reducing and non-reducing conditions, showed an apparent 27 filtration, indicating that it exists as monomer. It had NH2-terminal sequence Ile-Leu-Gly-Gly-Thr-Glu-Ala-Glu-Glu-Gly-Ser-Trp-Pro-Trp-Gln-Val-Ser-Leu-...
In an attempt to establish a standardized rating system for CT of the paranasal sinuses, Committee on Rhinology and Paranasal Sinus Disease American Academy Otolaryngology‐Head Neck Surgery instituted protocol review sinus scans at six international sites. Fifty identical were rated by four otolaryngologists each site according five established staging systems. Twenty 24 reviewers repeated session least 1 week later determine intrarater variability. The number that could not be classified...
Segmental bronchoprovocation (SBP) with allergen was used in an attempt to study eosinophils recruited the airway 24 h after challenge. Unexpectedly, first four patients, neutrophils (rather than eosinophils) were bronchoalveolar lavage (BAL) fluids, and we hypothesized that extracts contaminated endotoxin. The for challenge patients tested positive bacterial endotoxin a limulus amebocyte lysate assay. Rechallenge of one patient from group comparable dose endotoxin-free extract SBP five...
The expression of GHRH receptor (GHRH-R) messenger ribonucleic acid (mRNA) was studied in 22 pituitary adenomas and 2 normal anterior pituitaries. Northern blot analysis revealed that GHRH-R mRNA were expressed all 14 GH-producing adenomas, 1 3 ACTH-producing the PRL-producing adenoma, 4 nonfunctioning Their levels varied among relatively low GH-nonproducing adenomas. In addition to major transcript with a molecular mass 2.0 kilobases (kb), transcripts identified at 2.8 4.5 kb some To...
Sphingomyelin synthase 2 (SMS2) is the synthetic enzyme of sphingomyelin (SM), which regulates membrane fluidity and microdomain structure. SMS2 plays a role in LPS-induced lung injury inflammation; however, its inflammation-mediated tumorigenesis unclear. We investigated effect deficiency on dextran sodium sulfate (DSS)-induced murine colitis found inhibition DSS-induced inflammation SMS2-deficient (SMS2-/-) mice. DSS treatment induced significant increase ceramide levels, with decrease SM...
The binding and internalization of a novel adrenocorticotropic hormone (ACTH) analog having potent neuromodulating effect, ebiratide (H-Met(O2)-Glu-His-Phe-D-Lys-Phe-NH(CH2)8NH2), by isolated bovine brain capillaries, were examined. Metabolism [5-125I-His]ebiratide occurred during 30-min incubation with capillaries at 37 degrees C. In the presence 20 mM EDTA, added to inhibit this metabolism, medium, after 30 min incubation, contained 82.3 +/- 0.5% unchanged ebiratide. total acid-resistant...
SUMMARY Eosinophils and eosinophil granule proteins may play an important role in the pathogenesis of asthma. BALF from 40 patients with symptomatic asthma were analysed for cytokine activity by survival assay. 15 showed increased activity. Survival activities four these almost completely blocked anti-IL-5 MoAb, remaining anti-granulocyte-macrophage colony-stimulating factor (GM-CSF), anti-IL-3 antibody, or both. Surprisingly, samples other 25 decreased viabilities below levels medium...
Inhalation of the pulmonary irritant ozone is associated with an accumulation macrophages in lung. These cells, along type II epithelial are activated to release increased quantities hydrogen peroxide and nitric oxide, two reactive mediators that have been implicated tissue injury. In present studies we determined whether pretreatment rats bacterially derived endotoxin, which modulates oxidant levels tissues, could abrogate effects on lung injury oxide production. Acute exposure (2 parts per...