Abstract The Precambrian and lower Paleozoic units of the Japanese basement such as Hida Oki South Kitakami terranes have geological affinities with eastern Asia continent particularly strong correlation China block. There are also indications from Hitachi metamorphics Abukuma terrane blocks in Maizuru that some material may been derived North In addition to magmatism, region has seen substantial growth due tectonic accretion. accreted dominantly consist mudstone sandstone continental margin...

A novel trypsin-like protease was purified to homogeneity from the sputum of patients with chronic airway diseases, by sequential chromatographic procedures. The enzyme migrated on SDS-polyacrylamide gel electrophoresis a position corresponding molecular weight 28 kDa under both reducing and non-reducing conditions, showed an apparent 27 filtration, indicating that it exists as monomer. It had NH2-terminal sequence Ile-Leu-Gly-Gly-Thr-Glu-Ala-Glu-Glu-Gly-Ser-Trp-Pro-Trp-Gln-Val-Ser-Leu-...

Plate reconstructions of oceanic domains are generally based on paleo-magnetic and seafloor spreading records. However, uncertainties associated with such grow rapidly increasing geological age because the original plates have been subducted. Here we synthesize advances in seismic tomographic mapping subducted now lying within mantle that assist plate reconstructions. Our proposed Japan–NW Pacific subduction histories incorporate tomography results show three distinct stages comparable to...

1. Isoprenaline (10 nM to 1 microM) and forskolin (0.6‐100 depolarized single guinea‐pig myocytes studied in vitro. Under voltage clamp both agents caused an inward current flow. 2. These effects were abolished by propranolol (100 nM) the beta1‐antagonist metoprolol (100‐200 nM), but not beta2‐agonist [corrected] salbutamol (1 microM). 3. The interaction of isoprenaline with forskolin, caffeine or isobutylmethylxanthine (IBMX) on amplitude was as expected if all these drugs causing...

Abstract Igneous rocks associated with the Cretaceous to Paleogene volcanic arc in SW Japan show ages that young from west east a direction parallel Median Tectonic Line suggesting corresponding translation of heat source traditionally interpreted terms oblique subduction spreading ridge. However, recent oceanic plate reconstructions suggest ridge may be younger than main activity. Age compilations 1227 points felsic intermediate and Cenozoic igneous magmatism can separated into an early...

Abstract Carbonaceous material (CM) undergoes progressive changes that reflect its thermal history. These are in general irreversible and provide valuable information for understanding diagenetic metamorphic processes of crustal rocks. Among various approaches to quantify these changes, the R2 ratio, area ratio specific peaks CM Raman spectra, is widely used estimate maximum temperature intermediate- moderately high-grade metamorphism. The calculation requires peak deconvolution original...

The effects of changing temperature on the electrophysiology isolated cardiac myocytes guinea pig and Richardson's ground squirrel were studied by patch-clamp techniques. In cells from both species, resting membrane potential declined cooling 36 to 12 degrees C approximately 6 mV. duration plateau action in increased monotonically cooling. contrast, showed a biphasic response, increasing 24 then decreasing C. From voltage-clamp studies, properties L-type calcium currents (ICa) compared two...

1. The generation of action potentials elicited from enzymatically dispersed ventricular cells the frog, Rana catesbeiana, has been shown to be due influx both Na+ and Ca2+. maximum rate rise, amplitude duration at 50% repolarization potential were estimated 26.4 +/- 5.1 V/s (n = 8), 110 2.7 mV 8) 601 180 ms 15 degrees C, respectively. 2. Inward current (INa) was studied in these by whole-cell patch clamp technique a medium where Ca2+ eliminated substituting extracellular Mg2+ for K+...

We investigated qualitative and quantitative changes in rat hind limb muscles caused by complete Freund's adjuvant (CFA)‐induced knee joint pain. One week after CFA injection, muscle atrophy was induced only on the CFA‐injected side. Wet weight of rectus femoris (RF) soleus (SOL) were significantly decreased 20% 19%, respectively. The reduction cross‐sectional areas similar for fast slow fibers RF (10% vs 15%, respectively) SOL (16% 16%, respectively). At light microscopic level,...

Therapeutic approaches to treat joint contracture after anterior cruciate ligament (ACL) reconstruction have not been established. Arthrofibrosis accompanied by inflammation following ACL is a major cause of arthrogenic contracture. In this study, we examined whether anti-inflammatory treatment using low-level laser therapy (LLLT) can prevent reconstruction-induced Rats underwent transection and surgery in their right knees. Unoperated left knees were used as controls. After surgery, rats...

This study tested whether cell cycle inhibitor mitomycin C (MMC) prevents arthrogenic contracture progression during remobilization by inhibiting fibroblast proliferation and fibrosis in the joint capsule. Rat knees were immobilized a flexed position to generate flexion contracture. After three weeks, fixation device was removed rat allowed freely move for one week. Immediately after days fixator removal, rats received intra-articular injections of MMC or saline. The passive extension range...

Abstract Raman spectroscopy of carbonaceous material (RSCM) thermometry is an effective method to determine the thermal structure metasedimentary domains with high spatial resolution. The mean value numerous measurements in a single sample used for temperature estimation. A potential complicating factor presence detrital (CM) that can introduce bias results. Detrital CM generally shows degree crystallinity making it difficult discriminate and metamorphic high-grade domains. Application RSCM...

After anterior cruciate ligament (ACL) injury, a decrease in muscle strength associated with atrophy is frequently observed. The temporal and spatial effects of reconstructive surgery on have not been examined detail. This study aimed to 1) reveal the short mid-term atrophy, 2) investigate differences degree after ACL reconstruction hindlimb muscles. transection or without was performed unilaterally knees rats. Untreated rats were used as controls. At one four weeks post-surgery, relative...

Abstract A compilation of the thicknesses contact metamorphic aureoles (CMAs) developed around intermediate to felsic plutons shows many CMAs are far broader than expected by commonly used thermal models for pluton emplacement. Shortfalls in amount heat potentially provided based on size, compared that needed form observed CMA, can be accounted if some hot magma has been lost volcanic eruption after passing through domain and replaced new magma. high ambient temperature may also contribute...

Abstract Application of Raman spectroscopy carbonaceous material thermometry to samples metasedimentary rock from the low‐grade Sanbagawa belt in central Kii peninsula reveals a progressive decrease temperature ~390 °C close northern boundary, major continental shear zone—the median tectonic line (MTL)—to ~270 and ~7 km south roughly constant distribution thereafter. Within belt, thermal structure is not significantly modified by slip‐on fault boundaries between different geological units or...