A5075201209- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Medical Imaging Techniques and Applications
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Brain Tumor Detection and Classification
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Cardiac Arrest and Resuscitation
- Microtubule and mitosis dynamics
- Antifungal resistance and susceptibility
- Angiogenesis and VEGF in Cancer
- Advanced MRI Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Psychosomatic Disorders and Their Treatments
- Intracranial Aneurysms: Treatment and Complications
- Nail Diseases and Treatments
- Neurogenesis and neuroplasticity mechanisms
- stochastic dynamics and bifurcation
- Nuclear Receptors and Signaling
Gifu University
2008-2024
Saitama International Medical Center
2022-2024
Deleted Institution
2023
Tokyo Women's Medical University
2022
Gifu University Hospital
2009
Osaka University
2009
Nagahama Institute of Bio-Science and Technology
2009
A cancer stem cell population in malignant brain tumors takes an essential part tumor initiation, growth, and recurrence. Growth factors, such as epidermal growth factor, fibroblast factor-2, vascular endothelial platelet-derived hepatocyte are shown to support the proliferation of neural cells also may play key roles gliomagenesis. However, responsible factor(s), which controls maintenance cells, is not yet uncovered. We have established three lines from human gliomas. These were...
Although the majority of cases Alzheimer disease (AD) are known to be attributable sporadic (nongenetic) form disease, mechanism underlying its cause and progression still remains unclear.We found that vascular beta-amyloid (Abeta), Abeta40, inhibited proliferative activity human brain endothelial cells (HBECs) without toxic effects on them. This peptide also tube formation migration HBECs. Moreover, Abeta40 ex vivo hippocampal revascularization, reendothelialization, differentiation adult...
An auditory steady-state response (ASSR) is an electrophysiological to periodic stimuli that reflects the synchronization of endogenous oscillations. The 40-Hz ASSR reduced in patients with schizophrenia, bipolar disorder, and autism spectrum making it a candidate biomarker for these psychiatric disorders. Previous studies have revealed experimental conditions such as stimulus duration inter-stimulus interval tend affect ASSR, suggesting novelty detection may play important role determining...
Adipose tissue stromal vascular fraction contains mesenchymal stem cells, which show protective effects when administered to damaged tissues, mainly through secreted trophic factors. We examined the of adipose-derived cells (ASCs) and ASC-conditioned medium (ASC-CM) against retinal damage identified neuroprotective factors in ASC-CM. ASCs mature adipocytes were isolated from mouse subcutaneous tissue. injected intravitreally a model light-induced damage, ASC injection recovered function as...
Positron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based 2007 WHO classification; however, there no using new classification (the 2016 classification). Here, authors investigated relationship between uptake 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) astrocytic oligodendroglial tumors...
Spastic hypertonia usually occurs in patients with chronic disorders of consciousness (DOC) following severe traumatic brain injury (TBI). Spinal motor neuron excitability has been reported to increase damage. The aim this study was evaluate the immediate effects acupuncture on spinal DOC TBI by using evoked electromyography.Eleven male (mean age, 33 ± 14 years) refractory muscle spasticity upper extremity accompanying and admitted Chubu Medical Center for Prolonged Traumatic Brain...
Objective: To evaluate the immediate effect of acupuncture on cortico spinal tract (CST) activity in patients with chronic disorders consciousness (DOC) after traumatic brain injury (TBI) by measuring motor-evoked potential (MEP) using transcranial magnetic stimulation (TMS). Design: Changes several variables session were compared those control without same patients. Setting: Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Gifu, Japan. Patients: Fourteen (mean age ± standard...
Abstract Background and purpose The volume of excised tumor in contrast‐enhanced areas evaluated via magnetic resonance imaging is known to have a strong influence on the survival patients with glioblastoma (GBM). In this study, we investigated effect resection GBM 11 C‐methionine (MET) accumulation area using MET‐positron emission tomography (MET‐PET). Methods A total 26 (median age, 69 years; 15 males) who had undergone MET‐PET before after surgery, being newly diagnosed GBM, were included...
Introduction. Many patients with mild/moderate traumatic brain injury (m/mTBI) in the chronic stage suffer from executive function impairment. Analyzing metabolism is important for elucidating pathological mechanisms associated their symptoms. This study aimed to determine differences glucose between m/mTBI and without visible lesions based on MRI. Methods. Ninety due traffic accidents were enrolled divided into two groups MRI findings. Group A comprised 50 lesions. B 40 Patients underwent...
11 C-methionine (MET)-PET is a useful tool in neuro-oncology. The T2-fluid-attenuated inversion recovery (FLAIR) mismatch sign on MRI characteristic finding lower grade gliomas with isocitrate dehydrogenase (IDH) mutations and the absence of 1p/19q codeletion; however, T2-FLAIR has low sensitivity differentiating does not aid identifying glioblastomas IDH mutations. We therefore investigated efficacy combination MET-PET for accurately determining molecular subtype all grades.The present...
Owing to the several advantages that they have over other cells, mesenchymal stem cells are among most promising tools in cell therapy after ischemic stroke. Mesenchymal can be obtained from various sources. Therefore, a wide range of careful comparative studies these is required, preclinical stage (in vitro and vivo) clinical stage, order develop best with appropriate type. An vivo study this issue Stem Cell Research & Therapy compares therapeutic potential two types, bone marrow adipose...
To measure regional cerebral metabolic rate of glucose (CMRGlu) in patients with chronic disorders consciousness (DOCs) using 18F-fluorodeoxyglucose positron emission tomography (FDG-PET).This retrospective cohort study examined 50 (mean age: 40.9 ± 20.1 years) traumatic brain injury (TBI)-induced DOCs [minimally conscious state (MCS)+, n = 20; MCS-, 15 and vegetative (VS), 15]. We measured FDG-PET-based CMRGlu values 12 regions both hemispheres compared those among MCS+, MCS - VS...
11 C-Methionine (MET)-PET is a useful tool in neuro-oncology. This study aimed to examine whether combination of diagnostic variables associated with MET uptake could help distinguish between brain lesions that are often difficult discriminate conventional CT and MRI.MET-PET was assessed 129 patients glioblastoma multiforme, primary central nervous lymphoma, metastatic tumor, tumefactive multiple sclerosis, or radiation necrosis. The accuracy the differential diagnosis analyzed using five...
Objective: Patients with chronic disorders of consciousness (DOC) frequently develop constipation. This study evaluated the effects acupuncture on bowel movements (BMs) in patients DOC and constipation resulting from severe traumatic brain injury (TBI). Materials Methods: retrospective observational took place Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Kizawa Memorial Hospital, Minokamo, Gifu, Japan. The included 25 TBI, who received treatment. 2 sessions treatment per...
Abstract OBJECTIVE This study examined the correlation between cerebral blood volume (CBV) and MET PET. SUBJECTS AND METHODS 108 non-contrast-enhanced gliomas (41.8±12.3 years old, 58 males) April 2012 December 2022 were included. The pathological diagnosis was Glioblastoma, IDH-wildtype (G): 21 cases, Astrocytoma, IDH-mutant (A): 52, Oligodendroglioma, 1p/19q codeleted (O): 35. T2 region (the high signal on T2WI) MRI high-MET (tumor maximum SUV/normal frontal cortex SUV (T/N) ratio >...