A5070409732- Ovarian cancer diagnosis and treatment
- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Endometrial and Cervical Cancer Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic Disease and Treatment Approaches
- Systemic Sclerosis and Related Diseases
- Photochemistry and Electron Transfer Studies
- Liver Diseases and Immunity
- Aortic aneurysm repair treatments
- Intraperitoneal and Appendiceal Malignancies
- Synthesis and Catalytic Reactions
- Lymphoma Diagnosis and Treatment
- Glutathione Transferases and Polymorphisms
- Endometriosis Research and Treatment
- T-cell and B-cell Immunology
- Colorectal and Anal Carcinomas
- High-Velocity Impact and Material Behavior
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Treatment and Pharmacology
- Liver Disease Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Genomics, phytochemicals, and oxidative stress
- Connective tissue disorders research
- Protease and Inhibitor Mechanisms
ASKA Pharmaceutical (Japan)
2024
Research Management (Norway)
2024
Osaka Institute of Technology
2019
Soka Municipal Hospital
2016-2018
Kure Kyosai Hospital
2018
Aizawa Hospital
2015
Tottori Prefectural Central Hospital
2006-2012
Gifu University
2008-2011
National Defense Medical College
2000-2010
Fujita Health University
2010
Abstract Here, tumor-infiltrating CD11b+ myelomonocytoid cells in murine colon adenocarcinoma-38 and GL261 glioma were phenotypically characterized. Over 90% of the CD11b+F4/80+ monocyte/macrophage lineage. They also had a myeloid-derived suppressor cell (MDSC) phenotype, as they suppressed proliferation activated splenic CD8+ T CD11b+CD11c+Gr-1lowIL-4Rα+ phenotype. In addition, expressed CX3CR1 CCR2 simultaneously, which are markers an inflammatory monocyte. The MDSCs CD206, CXCL10, IL-1β,...
A molecularly imprinted synthetic polymer receptor selective for triazine herbicides was prepared by suspension polymerization, and applied to the specific solid-phase extraction of simazine, one herbicides, from water. The procedure involves reversed-phase mode operation retain lipophilic agrochemicals, including in water, followed affinity separation based on hydrogen bonding which exhibits retention eluting other undesired compounds. yielded a 56 times concentrated simazine solution with...
We aimed to establish an enzyme-linked immunosorbent assay for measuring soluble elastin fragments (sELAF) in serum and reveal its usefulness diagnosing acute aortic dissection (AAD).An measure sELAF was developed by using the newly created double monoclonal antibodies, which recognize different epitopes of human elastin. Twenty-five AAD patients, 50 patients with myocardial infarction (AMI), 474 healthy individuals were enrolled study. The levels from subjects gradually increased aging....
Positron emission tomography (PET) is important in the noninvasive diagnostic imaging of gliomas. There are many PET studies on glioma diagnosis based 2007 WHO classification; however, there no using new classification (the 2016 classification). Here, authors investigated relationship between uptake 11C-methionine (MET), 11C-choline (CHO), and 18F-fluorodeoxyglucose (FDG) isocitrate dehydrogenase (IDH) status (wild-type [IDH-wt] or mutant [IDH-mut]) astrocytic oligodendroglial tumors...
Abstract We attempted to determine whether various cytokine levels in the serum and synovial fluid (SF) of rheumatoid arthritis (RA) patients are influenced by performance filtration leukocytapheresis (LCP). The LCP procedure that used a Cellsorba® column (LCP group: n=22; responder subgroup: n=17, non‐responder n=5) or sham apheresis (control group; n=7) was repeated three times at 1‐week intervals. Serum group, control SF n=6; n=3) samples were collected before after LCP. Levels tumor...
BACKGROUND No useful predictor of resistance or sensitivity to second-line chemotherapy is known for ovarian cancer. The objective this prospective study was determine the utility tumor glutathione S-transferase-π (GST-π) expression (GSH) concentration in predicting cancer patients' responses chemotherapy. METHODS Tumor samples were obtained from 26 patients with relapsed epithelial 3-4 weeks before initiation etoposide (daily on Days 1-5) and cisplatin (on Day 5). GST-π determined by...
BACKGROUND Although p53 gene mutation frequently is observed in ovarian carcinoma, the function of chemosensitivity has not been defined conclusively. The objective current study was to elucidate relation between chemotherapy-induced apoptosis through pathway and carcinoma. METHODS Tumor samples were obtained from 24 patients with epithelial carcinoma before after chemotherapy cisplatin, doxorubicin, cyclophosphamide. Mutations screened by polymerase chain reaction–single-strand conformation...
BACKGROUND To clarify the role of glutathione (GSH) in chemotherapy resistance ovarian carcinoma, authors examined expression S-transferase-π (GST-π) and concentration tumors before after same patients. METHODS The cohort for this study comprised 20 patients with carcinoma who had residual disease primary surgery. These received two to three courses postoperative chemotherapy, then underwent surgery a second time. Chemotherapy consisted 50 mg/m2 cisplatin, 40 doxorubicin, 400...
The purpose of this study is to determine the changes in CD4+ T lymphocyte subsets circulating blood and synovial fluid following filtration leukocytapheresis (LCP) therapy for patients with rheumatoid arthritis (RA). A Cellsorba column packed polyester fibers was used removal leukocytes. For RA, LCP or sham procedures were performed 3 times 1 week intervals between procedures. surface markers peripheral measured by flow cytometry. proportions activated cells (CD4+DR+, CD4+CD25+, CD4+CD71+)...
Liquid marbles were prepared using a water droplet and nonprotonated hydrophobic poly(2-N,N-diisopropylaminoethyl methacrylate) (PDiPAEMA) powder. Although the PDiPAEMA was hydrophobic, became hydrophilic because of protonation pendant tertiary amino groups under acidic conditions. Therefore, liquid stabilized with powder could float on neutral to basic surface, but they immediately disintegrated an surface. Furthermore, floating surface in response CO2 gas as result carbonic acid formation.
<h3>Purpose:</h3> To assess the antitumor efficacy and safety of 2 treatment modalities: intraperitoneal carboplatin combined with intravenous (IV) paclitaxel. <h3>Patients Methods:</h3> Eligible patients were those epithelial ovarian carcinoma or primary peritoneal stages II to IV who underwent initial surgery had a residual tumor size cm larger. Patients received paclitaxel 175 mg/m<sup>2</sup> followed by AUC6. The end point was response. Secondary points toxicity, progression-free...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA New Synthesis of Highly Functional Nitrones through a Nitrosoketene Intermediate and Their Use for the Stereoselective Amino AcidsNobuya Katagiri, Hiroshi Sato, Ayumu Kurimoto, Makoto Okada, Akemi Yamada, Chikara KanekoCite this: J. Org. Chem. 1994, 59, 26, 8101–8106Publication Date (Print):December 1, 1994Publication History Published online1 May 2002Published inissue 1 December...
This report presents the case of a patient demonstrating multicentric Castleman's disease (MCD) with lung lesion that was successfully treated an anti-interleukin-6 receptor antibody, tocilizumab in combination corticosteroid and tacrolimus.A 43-yr-old female abnormal shadows on chest X-ray referred to hospital for further examination.She diagnosed as having MCD based characteristic pathology inguinal lymph node, lesions, laboratory data, undifferentiated arthritis.Corticosteroid rituximab...
The aim of this study is to clarify the effects cevimeline on various components in human saliva, such as immunoglobulin A (IgA), lysozyme, alpha-amylase and squamous cell carcinoma (SCC) antigen. Twelve female patients with Sjögren syndrome (SS) 14 healthy women were enrolled. After first saliva collection, one capsule (30 mg) was administered each subject. Saliva collected again after 90 min. salivary flow rate concentration component measured. In both groups amylase significantly...
Angiotensin (Ang) II plays an important role in fibrogenesis various organs, including the lung. The aim of this study is to elucidate (i) effects Ang on expression cytokines, growth factors or matrix proteins normal human lung fibroblasts, and (ii) inhibitory type 1 (AT1) receptor blocker, candesartan.Normal adult fibroblasts were cultured. Candesartan was added cells incubated. All culture dishes collected at day 0 2, cell numbers counted using a Neubauer haemocytometer (Clay-Adams,...
Assessment of the degree air-flow obstruction is important for determining treatment strategy in COPD patients. However, some elderly patients, measuring FVC impossible because cognitive dysfunction or severe dyspnea. In such patients a simple test airways requiring only short run tidal breathing would be useful. We studied whether spontaneous expiratory flow-volume (SEFV) curve pattern reflects patients.In 34 subjects (mean ± SD age 80 7 y) with stable (percent-of-predicted FEV(1) 39.0...
The availability of intravenous cyclophosphamide (CYC) pulse therapy for collagen vascular diseases (CVD)-associated interstitial lung disease (ILD) has been indicated. However, the standard protocol concerning dosage and interval CYC infusion not yet established. aim this study is to elucidate efficacy safety our "divided administration" treatment CVD-ILD. consists two steps: step 1, 400-500 mg at 10-day intervals least 30 days, 2, 500 14-day 4 weeks. ILD activities were monitored by...