A5043392549- Cancer Immunotherapy and Biomarkers
- SARS-CoV-2 and COVID-19 Research
- Moyamoya disease diagnosis and treatment
- Bladder and Urothelial Cancer Treatments
- Medical Imaging and Pathology Studies
- Cerebrovascular and Carotid Artery Diseases
- Tracheal and airway disorders
- Urinary and Genital Oncology Studies
- Intracranial Aneurysms: Treatment and Complications
- Immunotherapy and Immune Responses
- Helicobacter pylori-related gastroenterology studies
- Bone health and treatments
- Neurological Complications and Syndromes
- CAR-T cell therapy research
- Gastric Cancer Management and Outcomes
- Pneumonia and Respiratory Infections
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Radiopharmaceutical Chemistry and Applications
- Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Surgical Simulation and Training
- Emergency and Acute Care Studies
- Reconstructive Facial Surgery Techniques
- vaccines and immunoinformatics approaches
Kyoto University
2021-2025
Kyoto University Hospital
2022-2025
Kyoto University of Education
2025
Matsumoto University
2023
Musashi University
2006
Abstract Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of mRNA vaccines remains unclear. Using a vaccinated cohort ( n = 216), we demonstrated that older adults (aged ≥65 years) had fewer vaccine-induced spike-specific CD4 + including CXCR3 circulating follicular helper H 1 subset after first dose, which correlated with their lower peak IgG levels systemic adverse effects second compared younger adults. Moreover, expressed higher programmed cell death...
BACKGROUND Although bypass surgery can reduce rebleeding risk in hemorrhagic moyamoya disease, the remaining after is not negligible. We hypothesized that postoperative persistence of periventricular anastomosis (PA), a fragile collateral manifestation, associated with rebleeding. METHODS This retrospective cohort study included patients disease who underwent direct at 2 institutions presentation. Either presence or absence PA was radiologically determined by grading each subtype,...
Abstract Background The efficacy of neoadjuvant chemoradiotherapy for resectable pancreatic ductal adenocarcinoma (R-PDAC) remains unclear. This study was designed to evaluate by using intensity-modulated radiotherapy (NAC-IMRT) R-PDAC compared with upfront surgery (UpS). Methods Among 198 patients who were indicated resection between 2013 and 2021, 130 included in this after excluding underwent chemotherapy did not meet the NAC-IMRT criteria (Eligible set). planned 58 patients, UpS 72...
Background: Successive processing, a form of working memory function detected with the Das Naglieri Cognitive Assessment System (CAS), is selectively impaired in pediatric moyamoya disease (MMD). We aimed to test whether successive processing children MMD was improved after bypass surgery under control confounding. Methods: The present retrospective cohort study included who underwent direct or combined surgery. Neuropsychological tests including CAS were administered at two timepoints,...
This study aimed to evaluate retinal vessel structure using OCT, which enables high-resolution imaging for detailed vascular assessment. We investigated how age, sex, and body mass index (BMI) influence the OCT-measured parameters, including outer inner diameters (ODs IDs, respectively), wall thickness, reflectivity-parameters that are challenging assess color fundus photography. A cross-sectional retrospective study. The included 6981 participants in Nagahama Study, with eyes being...
Abstract Despite the high effectiveness of coronavirus disease (COVID-19) mRNA vaccines, both immunogenicity and reactogenicity show substantial interindividual variability. One key challenge is predicting low responders using easily measurable parameters. In this study, we performed multivariate linear regression analysis, which allows adjustment for confounding, to explore independent predictive factors antibody responses. Using data from 216 healthy vaccinated donors aged 23-81 years,...
<title>Abstract</title> Background In recent years, multigene assays have become indispensable tools for predicting the recurrence risk of estrogen receptor (ER)-positive, human epidermal growth factor 2 (HER2)-negative early-stage breast cancer and guiding adjuvant chemotherapy decisions. Curebest™ 95GC Breast (95GC), developed in 2011 as a domestically produced assay postoperative prediction, has been commercially available since 2013. Since 2021, five validation studies evaluating...
To assess the impact of histological variants on survival and response to treatment with pembrolizumab in patients chemo-resistant urothelial carcinoma (UC).The medical records 755 advanced UC who received were reviewed retrospectively. Patients classified into pure (PUC) each variant. Best overall (BOR) (OS) compared between groups using a propensity score matching (PSM).Overall, 147 (19.5%) harboured any variant (VUC). After PSM, there no significant differences objective rate (ORR, 24.5%...
Abstract Background Patients with rheumatoid arthritis (RA) are prone to muscle atrophy due inflammatory cytokines and corticosteroid use immobility joint pain deformity. Although resistance training is effective safe in reversing RA, some patients unable perform a conventional high-load exercise program disease-related limitations. This study aims examine the efficacy of individualized therapy on physical function elderly RA who at high risk for sarcopenia. Methods single-center,...
Abstract OBJECTIVES We developed a novel wireless localization technique after electromagnetic navigation bronchoscopy-guided radiofrequency identification marker placement for fluoroscopically invisible small lung lesions. conducted an observational study to investigate the feasibility of this and retrospectively compared 2 marking approaches with or without cone-beam computed tomography (CBCT). METHODS Consecutive patients from January 2021 March 2022 in our institution were enrolled....
Vonoprazan, a potassium-competitive acid blocker, is expected to be superior proton pump inhibitors (PPIs) in preventing post-endoscopic submucosal dissection (ESD)-induced gastric bleeding. However, the results of randomized controlled trials (RCTs) and observational studies on efficacy vonoprazan have been inconsistent. This study aimed evaluate effectiveness antithrombotic drug users, population that has excluded from RCTs. Treatment effects were assessed using cross-design synthesis,...
Background It is known that the mortality of pneumonia in patients with risk factors for aspiration worse than those without these factors. However, it still unknown which predict prognosis. Therefore, we aimed to determine are associated death or prolonged hospitalization.
Age-associated differences in the effect of repetitive vaccination, particularly on memory T-cell and B-cell responses, remain unclear. While older adults (aged ≥65 years) exhibited enhanced IgG responses following COVID-19 mRNA booster they produced fewer spike-specific circulating follicular helper T cells-1 than younger adults. Similarly, cytotoxic CD8
Polyglycolic acid (PGA) sheets are difficult to adapt the central airway because of poor durability against high air pressure. Therefore, we developed a novel layered PGA material cover and examined its morphologic traits functional performance as potential tracheal replacement.A critical-size defect in rat cervical tracheas was covered with material. Morphologic changes were bronchoscopically pathologically evaluated. Functional evaluated by regenerated ciliary area, beat frequency...
To investigate the relationship of followings for patients with moyamoya disease (MMD): arterial wall enhancement on vessel MRI (VW-MRI), cross-sectional area (CSA), time-of-flight MR angiography (MRA), age, locations from intracranial internal carotid artery (ICA) to proximal middle cerebral (MCA), progression, and transient ischemic attack (TIA).
Objectives Bleeding after endoscopic submucosal dissection (ESD) for gastric tumors in patients taking antithrombotic drugs, particular direct oral anticoagulants (DOACs), remains unresolved; therefore, we evaluated the risk factors post‐ESD bleeding and drug differences DOACs. Methods We included 278 drugs who underwent ESD between January 2017 March 2022. Antithrombotic were withdrawn following guidelines (Appendix on including DOACs). To further clarify agents' effects, peri‐cancerous...
The treatment and prognosis of de novo metastatic hormone-sensitive prostate cancer (mHSPC) vary. We established validated a novel prognostic model for predicting cancer-specific survival (CSS) in patients with mHSPC using retrospective data from contemporary cohort.
This study evaluated the effect of intratracheal administration basic fibroblast growth factor (bFGF) on tracheal healing following implantation a novel layered polyglycolic acid (PGA) material to replace critical-size defect in rat trachea.
Cultural adaptation is essential for optimizing programs centered around autonomy, such as the Serious Illness Care Program (SICP), especially populations valuing family-involved decision-making.