A5103142492- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Helicobacter pylori-related gastroenterology studies
- Inflammatory Bowel Disease
- Pancreatitis Pathology and Treatment
- Microscopic Colitis
- Chronic Lymphocytic Leukemia Research
- IgG4-Related and Inflammatory Diseases
- Abdominal vascular conditions and treatments
- Esophageal Cancer Research and Treatment
- Potassium and Related Disorders
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Parasite Biology and Host Interactions
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Infectious Diseases and Mycology
- Leech Biology and Applications
- Study of Mite Species
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders
- Colorectal Cancer Surgical Treatments
- Inflammation biomarkers and pathways
Kagawa Prefectural Central Hospital
2013-2025
Nagasaki University
2000-2025
Toranomon Hospital
2011
Okayama Prefecture
2009
Abstract Background and Aim: Endoscopic submucosal dissection (ESD) is a useful procedure for the treatment of early gastric neoplasms; however, this advanced technique has also resulted in an increase serious complications such as perforation delayed bleeding. This study aimed to elucidate risk factors these complications. Methods: A total 1123 lesions diagnosed with neoplasms treated by ESD at three institutions were investigated. Retrospectively, patients or without compared on basis...
Summary Background Vonoprazan, a potassium‐competitive acid blocker, is expected to improve the healing of endoscopic submucosal dissection ( ESD )‐induced gastric ulcers compared with proton pump inhibitors PPI s). Aim To compare status ‐induced and incidence post‐ bleeding between subjects treated vonoprazan for 5 weeks those s 8 weeks. Methods Patients in group n = 75) were prospectively enrolled, whereas patients 150) selected 2:1 matched historical control cohort according baseline...
ABSTRACT Objective The global prevalence of nontuberculous mycobacterial pulmonary disease (NTM‐PD) has been steadily increasing. A few small retrospective studies have reported a poor prognosis associated with chronic aspergillosis (CPA) as complication NTM‐PD. Furthermore, the prognostic impact CPA may inadequately assessed due to differences in background factors. This study aimed identify risk factors for NTM‐PD and compare in‐hospital mortality between patients without aspergillosis....
The long-term use of proton pump inhibitors (PPIs) can induce fundic gland polyps (FPs) in the stomach, sometimes leading to numerous large FPs (LFPs). Although PPI discontinuation reduce LFP size and number, underlying process remains unstudied. A 63-year-old woman on esomeprazole (20 mg daily for 10 years) was scheduled endoscopic removal. After discontinuation, her LFPs regressed <10 mm within 35 days. 60-year-old male physician rabeprazole (10 12 had detected via...
A 30-year-old female patient had an 8-cm retroperitoneal mass that was incidentally discovered during abdominal computed tomography (CT) scan performed for diagnosing ischemic colitis, resulting in her referral to our hospital. CT-guided needle biopsy with a 20G needle, but the results were inconclusive. 14G used after weighing benefits and harms, diagnosis of hyaline-vascular variant Castleman disease. No laboratory or imaging features are specific unicentric disease, occurrence has been...
Although the frequency of residual disease and recurrence following endoscopic submucosal dissection (ESD) has markedly decreased, a few cases ESD are still observed. The aims present study were to clarify causes non-curative resection investigate risk factors. A total 1,123 early gastric neoplasm lesions treated by investigated. Non-curative was defined as histological positivity resected margins, vascular invasion or failure en bloc resection. Cases classified being caused one three...
Dasatinib, a second-generation tyrosine kinase inhibitor, is widely used in patients with haematological malignancies. The main side effects of dasatinib are myelosuppression and pleural effusion; however, colitis, such as haemorrhagic colitis cytomegalovirus (CMV) have been reported rare effects. There only few studies conducted on dasatinib-induced colitis.This study aimed to clarify the clinical, endoscopic pathological features retrospective included 51 consecutive who received therapy...
A 24-year-old man was referred to our hospital due bilateral hilar lymphadenopathy on chest radiography. He had been under medication for aortitis syndrome and Crohn's disease 12 years. Surgical biopsy from the anterior segment of left upper lobe mediastinal lymph nodes performed video-assisted thoracoscopy. Histopathological examination revealed epithelioid cell granulomas without caseous necrosis, compatible with sarcoidosis. Full sequence analysis CARD15 gene, which is reportedly related...
A 74-year-old woman developed acute severe colitis after receiving her sixth mRNA vaccine against coronavirus disease-2019 (COVID-19). On the day vaccination, she experienced bloody diarrhea, abdominal pain, and high-grade fever. Laboratory tests revealed leukocytosis increased C-reactive protein. Contrast-enhanced computed tomography bowel wall thickening with a reduced contrast effect within colon, in addition to ascites. Sigmoidoscopy extensive sloughing of mucosa. Her symptoms laboratory...
Salvage therapy for esophageal cancer following chemo-radiation (CRT) has not been established. We aimed to evaluate endoscopic submucosal dissection (ESD) as a salvage based on histopathological features of lesions. compared 10 lesions in eight patients with local residual, recurrent, or metachronous squamous cell carcinoma treated by ESD after CRT (CRT group) and 59 without (non-CRT during the same period. The en bloc resection rate was 100 % while complete 80.0 CRT, indicating no...
The piscicolid leech, Limnotrachelobdella okae (Moore, 1924), was found to be parasitic on Japanese seaperch, Lateolabrax japonicus (Lateolabracidae), from Tokyo Bay and kusafugu, Takifugu niphobles (Tetraodontidae), the Sea of Japan in Yamagata, Japan. This species also collected bastard halibut, Paralichthys olivaceus (Paralichthyidae), pufferfish, rubripes cultured Seto Island Sea, Okayama, These 4 fish are new hosts for L. okae. Based a wide range different taxonomic groups (11 7...
Bleeding after endoscopic submucosal dissection (ESD) in antithrombotic drug users is still one of the important issues to be solved. We performed scheduled second-look endoscopy (SLE) 5 days ESD, when resumption agents assumed have achieved a steady state, rather than on day ESD. investigated bleeding incidence and status ulcers.A total 299 lesions patients subjected ESD for gastric neoplasms were enrolled. A double dose proton pump inhibitors was administered SLE planned Post-ESD occurring...
Interleukin-12 (IL-12) is thought to play an important role as a modulator of levels IL-10 and interferon-γ (IFN-γ). To address the therapeutic effects rIL-12 in endogenous sepsis model mice, which closely mimics pathophysiology septicaemia man, on cytokines such IFN-γ, survival septic mice infected with Pseudomonas aeruginosa PAO1 were examined. First, model, serum IFN-γ remained normal until days 8 10, respectively, when significant rises seen. On day 11, returned normal, but high....
Abstract Causative agent identification is important in the treatment of poisoning. We report case a patient who presented with an altered level consciousness after drinking fluorescent pink liquid. Upon measuring anion gap and urinary calcium oxalate level, was diagnosed early ethylene glycol
Abstract Background The utility of intestinal ultrasound (IUS) on remission induction therapy for acute ulcerative colitis (UC) has not been fully addressed. Aims To elucidate the effectiveness IUS assessment therapy. Methods In all, 107 sites in 32 patients (12 with severe colitis, 20 moderate colitis) were analyzed. Disease activity was assessed as Mayo endoscopic score (MES) by colonoscopy. US grade and bowel wall thickness (BWT) before compared MES. Changes BWT after clinical improvement...
Objectives Bleeding after endoscopic submucosal dissection (ESD) for gastric tumors in patients taking antithrombotic drugs, particular direct oral anticoagulants (DOACs), remains unresolved; therefore, we evaluated the risk factors post‐ESD bleeding and drug differences DOACs. Methods We included 278 drugs who underwent ESD between January 2017 March 2022. Antithrombotic were withdrawn following guidelines (Appendix on including DOACs). To further clarify agents' effects, peri‐cancerous...
An 83-year-old Japanese man who underwent cholecystectomy for cholecystolithiasis 17 years ago visited our hospital owing to epigastric pain. He was initially diagnosed with choledocholithiasis and acute cholangitis following white blood cell, C-reactive protein, total bilirubin, alkaline phosphatase, γ-glutamyltranspeptidase level elevations along common bile duct stones on computed tomography (CT). Moreover, CT, magnetic resonance imaging, endoscopic retrograde cholangiography (ERC),...
症例は47歳女性.2年前に右乳癌に対して切除術を受け,その後,タモキシフェンを内服していた.タモキシフェン内服開始27ヶ月後に左側腹部痛が出現し,血液検査で膵酵素が上昇し,CTでは,膵腫大と左前腎傍腔に脂肪壊死を認めたため,急性膵炎と診断された.絶食と補液などの保存的治療で軽快し,入院13日目に退院した.入院時,血中トリグリセリド値が5512mg/dlと著明に上昇しており,急性膵炎の原因としてタモキシフェン投与による高脂血症が考えられた.入院時からタモキシフェンを中止したところ,血中トリグリセリド値は速やかに低下し,退院4ヶ月後には基準値内となった.タモキシフェンによる著明な高脂血症とそれによる急性膵炎発症の頻度は稀だが,重篤になることがある.タモキシフェン投与中の患者は,血中トリグリセリド値の定期的な経過観察が必要であり,上昇していれば,迅速な対応が必要である.