A5047822717- Chemical Reaction Mechanisms
- Chemical Reactions and Mechanisms
- Inorganic and Organometallic Chemistry
- Lung Cancer Treatments and Mutations
- Analytical Chemistry and Chromatography
- Porphyrin and Phthalocyanine Chemistry
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Oxidative Organic Chemistry Reactions
- Chemical Synthesis and Reactions
- Synthetic Organic Chemistry Methods
- Molecular spectroscopy and chirality
- Photochemistry and Electron Transfer Studies
- Radical Photochemical Reactions
- Various Chemistry Research Topics
- Chemical Reactions and Isotopes
- Fluorine in Organic Chemistry
- Organic Chemistry Cycloaddition Reactions
- Lung Cancer Research Studies
- Cancer-related Molecular Pathways
- Free Radicals and Antioxidants
- Molecular Sensors and Ion Detection
- Cancer Treatment and Pharmacology
- PI3K/AKT/mTOR signaling in cancer
- Cancer therapeutics and mechanisms
Kagawa Prefectural Central Hospital
2018-2024
Kindai University
2009-2020
Kishiwada City Hospital
2015-2017
Saitama International Medical Center
2013
Saitama Medical University
2013
Astellas Pharma (Japan)
2011
Kyushu University
2011
Yasuda Women's University
2010
Kyoto Prefectural University of Medicine
2002
Denso (United States)
1996
Nephrotoxicity remains a problem for patients who receive cisplatin chemotherapy. We retrospectively evaluated potential risk factors cisplatin-induced nephrotoxicity as well the impact of intravenous magnesium supplementation on such toxicity.We reviewed clinical data 401 underwent chemotherapy including high dose (≥60 mg/m2) in first-line setting. was defined an increase serum creatinine concentration at least grade 2 during first course chemotherapy, assessed basis National Cancer...
Abstract The molecular mechanism by which epidermal growth factor receptor–tyrosine kinase inhibitors (EGFR-TKI) induce apoptosis in non–small cell-lung cancer (NSCLC) cells that are positive for activating mutations of the EGFR remains unclear. In this study, we report effects EGFR-TKI gefitinib on expression antiapoptotic protein survivin have functional consequences mutation–positive NSCLC cells. Immunoblot analysis revealed downregulated expression, likely through inhibition PI3K-AKT...
Loss of PTEN was recently shown to contribute resistance epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) in EGFR mutation-positive non-small cell lung cancer (NSCLC) through activation the protein AKT. We previously showed that downregulation expression antiapoptotic survivin by EGFR-TKIs contributes EGFR-TKI-induced apoptosis NSCLC cells. have now investigated role EGFR-TKI induced loss. The erlotinib did not affect or induce cells with Downregulation either...
We previously showed that tumor-derived heregulin, a ligand for HER3, is associated with both de novo and acquired resistance to cetuximab. have now examined whether patritumab, novel neutralizing monoclonal antibody able overcome such resistance. Human colorectal cancer (DiFi) cells are highly sensitive cetuximab were engineered stably express heregulin by retroviral infection, the effects of patritumab on resulting DiFi-HRG examined. released substantial amounts Cetuximab alone inhibited...
Therapeutic strategies that target c-Src hold promise for a wide variety of cancers. We have now investigated both the effects dasatinib, which inhibits activity and several other kinases, on cell growth as well mechanism dasatinib resistance in human gastric cancer lines. Immunoblot analysis revealed activation at various levels most lines examined. Dasatinib inhibited phosphorylation extracellular signal-regulated kinase (ERK) induced G(1) arrest, by flow cytometry, subset responsive In...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1,2:3,4:5,6-Tris(bicyclo[2.2.2]octeno)tropylium ion: an all-hydrocarbon carbocation with extraordinary stabilityKoichi. Komatsu, Hidekazu. Akamatsu, Yasuhisa. Jinbu, and Kunio. OkamotoCite this: J. Am. Chem. Soc. 1988, 110, 2, 633–634Publication Date (Print):January 1, 1988Publication History Published online1 May 2002Published inissue 1 January 1988https://pubs.acs.org/doi/10.1021/ja00210a072https://doi.org/10.1021/ja00210a072research-articleACS...
Abstract The kinetics of the reactions trimethylamine, dimethylamine, methylamine, and ammonia with methyl iodide in aqueous solutions have been investigated at temperatures ranging from 0 to 40°C. Kinetic analyses consecutive methylations dimethylamine methylamine conducted according method French. In case a standard second-order kinetic treatment can be successfully used because relative sluggishness first stage as compared succeeding stages. observed rates are sequence:...
Amatuximab is a chimeric monoclonal antibody that targets mesothelin, which expressed in virtually all mesotheliomas and pancreatic adenocarcinomas. The objective of this study was to determine the dose-limiting toxicity maximum tolerated dose. Patients with mesothelioma, adenocarcinoma or other mesothelin-positive solid tumors were eligible for study. administered weekly as an intravenous infusion 4-week cycles at progressively increasing doses ranging from 50 200 mg/m(2). Seventeen...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and properties of hydrocarbon saltsKunio Okamoto, Toshikazu Kitagawa, Kenichi Takeuchi, Koichi Komatsu, Tomomi Kinoshita, Shuji Aonuma, Minoru Nagai, Atsushi MiyaboCite this: J. Org. Chem. 1990, 55, 3, 996–1002Publication Date (Print):February 1, 1990Publication History Published online1 May 2002Published inissue 1 February 1990https://pubs.acs.org/doi/10.1021/jo00290a034https://doi.org/10.1021/jo00290a034research-articleACS...
Abstract The polysubstituted tropylium ions having cyclopropyl or t-butyl groups at the ring positions with least steric hindrance, i.e. 1,3- and 1,4-dicyclopropyltropylium, 1,4-di-t-butyltropylium, 1,3,-5-tricyclopropyl- 1,3,5-tri-t-butyltropylium 1,2,4,6-tetracyclopropyltropylium (4), were synthesized, their properties compared known monosubstituted unsubstituted cations. 1H 13C NMR spectra for derivatives exhibited a gradual upfield shift seven-membered signals upon consecutive...
The one-electron reduction of the unsubstituted, methyl-, ethyl-, isopropyl-, t-butyl-, triphenylmethyl-, and phenyltropylium ions with Cr(II) in a 10% HCl solution gives, quantitatively, dimer corresponding substituted tropyl radical. measurements reaction rate at 25°C exhibit this order reactivity: t-butyltropylium (k2=7.98 l/g·ion·sec), isopropyltropylium (8.22), ethyltropylium (10.3), methyltropylium (11.1), tropylium (74.0), (144), triphenylmethyltropylium (567) ions. values log k2 have...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOn the Distribution of Oxygen-18 in Triphenylmethyl Benzoate from Reaction and Benzoyl Peroxide carbonyl-18OW. von E. Doering, Kunio Okamoto, H. KrauchCite this: J. Am. Chem. Soc. 1960, 82, 14, 3579–3582Publication Date (Print):July 1, 1960Publication History Published online1 May 2002Published inissue 1 July 1960https://pubs.acs.org/doi/10.1021/ja01499a026https://doi.org/10.1021/ja01499a026research-articleACS PublicationsRequest reuse...
Abstract 1. Titrimetric and polarimetric rate constants (Kt kα) for phenolysis of α-phenethyl chloride in 50wt.% phenol-benzene at 25°C were measured, satisfactory first-order behavior was observed irrespective presence or absence anilinium phenolate. From this the SN1-characteristics concluded. 2. The values kα’s fairly constant any phenolate concentrations (0.0∼0.6 n). kt’s also higher concentrations. However, Kt’s gave smaller than Kα’s, showed a sudden decrease vicinity zero...
Abstract A series of polymethylenebis(diphenylcyclopropenium) dications with the polymethylene chain one to six carbons (4n=1–6) were synthesized and characterized by spectral analytical means. Among 4n=3–6 which isolated as perchlorates, 4n=3 was shown pKR+ measurements be destabilized 1.3 pK units compared 4n=4–6. The values reduction potential exhibited same tendency. chromium(II) ion 4n=6, a representative dication, afforded polymeric material containing hexylbenzene unit. dication 4n=2...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT1-Aryl-8-tropylionaphthalene perchlorates: synthesis and intramolecular charge-transfer interactionKoichi Komatsu, Nobuyuki Abe, Kenji Takahashi, Kunio OkamotoCite this: J. Org. Chem. 1979, 44, 15, 2712–2717Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://pubs.acs.org/doi/10.1021/jo01329a024https://doi.org/10.1021/jo01329a024research-articleACS PublicationsRequest reuse...
Abstract Adamantyl derivatives, the bridgehead substrates, have been chosen as reference compounds in assessment of ionizing power phenolic solvents ,SN1-type solvolysis. The SN1-phenolyses 1-adamantyl chloride, bromide, and p-toluenesulfonate studied at several temperatures binary mixtures phenol with benzene; enthalpies entropies activation calculated. Phenolysis has also made on t-butyl chloride order to estimate Grunwald-Winstein Y values for phenol-benzene solvents. solvolysis rates...