A5076680045- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- COVID-19 Clinical Research Studies
- Antifungal resistance and susceptibility
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Emergency and Acute Care Studies
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Outbreaks Research
- Fungal Infections and Studies
- Bacterial Infections and Vaccines
- Mosquito-borne diseases and control
- Tracheal and airway disorders
- Infectious Diseases and Mycology
- Diphtheria, Corynebacterium, and Tetanus
- Bacterial biofilms and quorum sensing
- COVID-19 and healthcare impacts
- Abdominal vascular conditions and treatments
- Viral Infections and Vectors
- Infectious Aortic and Vascular Conditions
- COVID-19 epidemiological studies
- Microbial infections and disease research
Nagasaki University Hospital
2012-2025
Yokufukai Hospital
2023
Nagasaki University
2002-2018
Hamamatsu University School of Medicine
2006
Monash University
2006
National Hospital of Pediatrics
2006
Kawasaki Medical School
2006
Kyorin University Hospital
2001
ABSTRACT Objective The global prevalence of nontuberculous mycobacterial pulmonary disease (NTM‐PD) has been steadily increasing. A few small retrospective studies have reported a poor prognosis associated with chronic aspergillosis (CPA) as complication NTM‐PD. Furthermore, the prognostic impact CPA may inadequately assessed due to differences in background factors. This study aimed identify risk factors for NTM‐PD and compare in‐hospital mortality between patients without aspergillosis....
Abstract Background Recently, the number of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has increased worldwide. The most common causative organism in Japan is Mycobacterium avium complex (MAC). incidence MAC (MAC-PD) higher than that other countries, and deaths from MAC-PD are increasing. Complex cases involving radiological fibrocavitary patterns aspergillosis have been reported as poor prognostic factors; however, available evidence limited. To address this gap,...
Background and objective: Nontuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic respiratory infection with increasing prevalence mortality worldwide. Chronic aspergillosis (CPA) significant complication of NTM-PD associated poor prognosis. In this multicenter, retrospective, cohort study, we examined the epidemiology, comorbidities, risk factors for CPA coinfection, long-term prognoses patients infected in Japan. Methods: Patients aged ≥18 years newly diagnosed who visited 18...
Long-term hospital stay is associated with functional decline in patients pneumonia, especially the elderly. Among elderly aspiration pneumonia a major category. Clinical definition usually used because it can occur without apparent episodes. It still not clear whether long-term due to itself caused by underlying oropharyngeal dysfunction or simply multiple comorbidities during acute infection. The aim of this study identify clinically defined was stay.A prospective observational on...
Objective The advantage of transbronchial biopsy (TBB) using endobronchial ultrasonography (EBUS) with a guide sheath (GS) over TBB without EBUS guidance was investigated in this study. Materials and Methods A retrospective chart review conducted at Nagasaki University Hospital, Japan. Data were collected from all cases peripheral pulmonary lesions (PPLs) undergoing either EBUS-GS-guided or our department December 2003 through November 2009. diagnostic yield each group compared, after...
Antibody responses to a 23-valent pneumococcal vaccine for Streptococcus pneumoniae serotypes 6B, 14, 19F, and 23F in 84 patients with chronic pulmonary diseases over 2-year period after vaccination were examined by using third-generation enzyme-linked immunosorbent assay. Of these patients, 28 (31%) low responders who had developed increases of at least twofold the levels serotype-specific immunoglobulin G (IgG) sera none four 1 month vaccination. Although no specific clinical features...
Corynebacterium propinquum, which is included in group ANF-3, exists as a commensal the oral flora. This organism has not yet been fully recognized respiratory pathogen. Wepreviously reported that first case with infection caused by C. propinquum. On other hand, pseudodiphtheriticum causative infections. Recently we experienced two cases Propinquum infections our hospital. Three types of onset such community-acquired infection, hospital-acquired and nursing home acquired were observed. Our...
ABSTRACT The lack of reliable diagnostic tests for detecting vaccine serotype pneumococcal pneumonia (VTPP) remains a challenging issue in studies. This study assessed the performances high-throughput nanofluidic PCR-based serotyping and quantification assay methods using sputum samples (the quantitative PCR [Sp-qPCR] assay) to diagnose 13-valent conjugate VTPP compared with performance serotype-specific urinary antigen detection (UAD) urine samples. Adult patients from Japan were enrolled...
Tuberculous meningitis is an infectious disease with high mortality. Literature describing intrathecal therapy for tuberculous scarce. We herein report a case of refractory in 52-year-old woman underlying neuropsychiatric systemic lupus erythematosus. Despite treatment anti-tuberculosis drugs and dexamethasone, her meningeal irritation deteriorated. Intrathecal isoniazid prednisolone administration was therefore initiated, the symptoms severe improved along head magnetic resonance imaging...
It is challenging to diagnose infected aneurysm in the early phase. This study aimed describe clinical and microbiological characteristics of aneurysm, elucidate difficulties diagnosing disease.Forty-one cases were diagnosed Nagasaki University Hospital from 2005 2019. Information on characteristics, radiological findings, duration onset, type initial computed tomography (CT) imaging conditions collected. Factors related diagnostic delay analyzed by Fisher's exact test for categorical...
Severe fever with thrombocytopenia syndrome (SFTS) and Japanese spotted (JSF; a group rickettsiosis) are tick-borne zoonoses that becoming significant public health threat in Japan East Asia. Strategies for treatment infection control differ between the two; therefore, initial differential diagnosis is important. We aimed to compare clinical characteristics of SFTS JSF based on symptomology, physical examination, laboratory data, radiography findings at admission. This retrospective study...
A 38-year-old man presented to a previous hospital in December 2011 with high fever and acute abdominal pain. He was found have lymphadenopathy diagnosed HIV infection. His CD4 count 25/mm3 viral load 490 000 copies/mL. transferred our department for further investigations treatment. Whole body CT revealed bulky, widespread lymphadenopathy, especially the abdomen, but no ascites or pleural effusion (figure 1A, B). Stool, bone marrow an lymph node specimen were positive acid-fast bacillus...
Corynebacterium propinquum, which is classified as ANF-3, has not yet been described a cause of the respiratory infections. In this paper, we reported case 67-year-old immunocompetent male with community-acquired pneumonia caused by C. propinquum. Our study suggested that Gram staining pulurent sputum was most important diagnostic tool to determine pathogenecity organism.
Objective: The aim of this study was to investigate the causative organisms community‐acquired pneumonia (CAP) diagnosed between 2000 and 2002 evaluate Japanese Respiratory Society (JRS) guidelines. Methodology: A total 124 cases CAP during period were analyzed, results compared with those a previous by authors’ research group. Determination based on Gram stain, morphology colonies, quantitative culture sputum, identification bacterial isolates, serological tests. Results: During period,...
Abstract The effectiveness of population-wide compliance to personal precautions (mask-wearing and hand hygiene) in preventing community-acquired pneumonia has been unknown. In Japan, different types nonpharmaceutical interventions from containment closure policies (CACPs, e.g. stay-at-home requests) were sequentially introduced late January April 2020, allowing for separate analysis the effects other more stringent interventions. We quantified reduction hospitalizations deaths assessed if...
A 77-year-old man with urinary tuberculosis developed post renal anuria two days after starting an anti-tuberculosis drug regimen. He had bilateral hydronephrosis, and his right kidney was radiologically diagnosed to be non-functioning. transurethral catheter placed in the left ureter. No improvement ureteral stricture noted during initial three weeks of treatment; however, did thereafter improve commencement oral prednisolone. In cases tuberculosis, can deteriorate result obstruction...