A5048601539- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Respiratory viral infections research
- Pneumocystis jirovecii pneumonia detection and treatment
- Streptococcal Infections and Treatments
- Antimicrobial Resistance in Staphylococcus
- Infective Endocarditis Diagnosis and Management
- Influenza Virus Research Studies
- Immunodeficiency and Autoimmune Disorders
- Antifungal resistance and susceptibility
- Antibiotic Resistance in Bacteria
- Antibiotics Pharmacokinetics and Efficacy
- Virology and Viral Diseases
- Neonatal and Maternal Infections
- Fungal Infections and Studies
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Respiratory and Cough-Related Research
- Congenital Diaphragmatic Hernia Studies
- Parvovirus B19 Infection Studies
- Tracheal and airway disorders
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Bacterial Identification and Susceptibility Testing
- Infectious Diseases and Tuberculosis
Chiba University Hospital
2016-2025
Chiba University
2008-2025
Japan Pediatric Society
2020-2024
National Center For Child Health and Development
2021
Japan Society of Chemotherapy
2020
Respiratory and Meningeal Pathogens Research Unit
2012
Medical Research Council
2012
GlaxoSmithKline (Belgium)
2012
Pediatrics and Genetics
2009
Bridge University
2009
The members of the Japanese Society for Pediatric Infectious Diseases and Pulmonology have developed Guidelines Management Respiratory in Children with objective facilitating appropriate diagnosis, treatment prevention respiratory infections children. first edition was published 2004 fifth 2022. Guideline 2022 consists 2 parts, clinical questions commentary, includes general specific children underlying diseases severe infections. This executive summary outlines 2022, reference to Medical...
Eleven children with acute encephalopathy associated an influenza virus infection were treated during the 1997-1998 season. Reverse transcription-polymerase chain reaction (RT-PCR) assay was used to detect viral genome in peripheral blood and cerebrospinal fluid (CSF) samples. The results compared those of control patients without neurological complications. Viral RNA detected only mononuclear cells one patient influenza-virus-associated (1 9; 11%) CSF another 11;9%). RT-PCR negative all...
Background: Nationwide surveillance was conducted in Japan to clarify the status of pediatric invasive pneumococcal diseases (IPD) after introducing a 13-valent conjugate vaccine (PCV13).Methods: Detailed clinical and epidemiologic information IPD cases children aged <15 years were collected from 10 47 prefectures January 2014 December 2022. Streptococcus pneumoniae strains isolated sterile body sites analyzed, including capsular serotypes, multi-locus sequence typing (MLST), antimicrobial...
Nationwide surveillance was conducted in Japan to clarify the status of pediatric invasive pneumococcal diseases (IPD) after introducing a 13-valent conjugate vaccine (PCV13). Detailed clinical and epidemiologic information IPD cases children aged <15 years collected from 10 47 prefectures January 2014 December 2022. Streptococcus pneumoniae strains isolated sterile body sites were analyzed including capsular serotypes, multi-locus sequence typing (MLST), antimicrobial susceptibility...
Background Studies on microorganisms in a large cohort of patients with congenital heart disease (CHD) and infective endocarditis (IE) are rare. Using nationwide survey, the relationship between causative clinical profiles CHD IE was investigated. Methods Results Data from 188 (pediatric (n=113), mean age, 6.2±4.9 years; adult (n=75), age 28.4±13.4 years) 60 institutions were analyzed. Causative Streptococcus species (94:50.0%), Staphylococcus (68:36.2%), Haemophilus (9:4.8%), Candida...
Studies on community-acquired pneumonia (CAP) and pneumococcal (PP) related to the 13-valent conjugate vaccine (PCV13) introduction in Asia are scarce. This study aimed investigate epidemiological microbiological determinants of hospitalised CAP PP after PCV13 was introduced Japan. observational hospital-based surveillance included children aged ⩽15 years, admitted hospitals around Chiba City, Participants had bacterial based a positive blood or sputum culture for pathogens. Serotype...
Background: The clinical features of coronavirus disease 2019 (COVID-19) in children have been changing because the emergence and rapid spread variants concern (VOC). increase cases infected with VOC has brought persistent symptoms after COVID-19 children. This survey aimed to analyze manifestations pediatric Japan. Methods: We analyzed reported between February 2020 April 2022 Japan, using a dedicated database updated voluntarily by members Japan Pediatric Society. Using same database, we...
Early stage Kawasaki disease (KD) histopathology includes perivasculitis and vasculitis of the microvessels. The lesions then extend to larger vessels. Therefore analysis microvessel is important better understand initial pathogenesis KD vasculitis.We studied epicardial (<50 microm) aneurysm paraffin-embedded cardiac tissues from 4 Japanese patients who died 7 22 days after onset. cellular composition in was different that coronary lesions; eosinophils were preferentially accumulated...
Group B Streptococcus (GBS) is one of the leading causes neonatal bacterial infections. Population-based surveillance GBS-related invasive diseases among newborns and infants from 10 prefectures in Japan was performed between 2007 2012. The characteristics cases isolated GBS are described this study. incidence rate 0.13 per 1,000 live births. Analysis samples obtained 60 showed that most frequent serotypes were III (48.3%), Ia (30.0%), Ib (10.0%). All isolates susceptible to penicillin G,...
Haemophilus influenzae type b (Hib) conjugate vaccines have led to dramatic reductions in Hib disease among young children worldwide. Nontypeable H. (NTHi) is now the major cause of invasive infections. We investigated clinical characteristics NTHi diseases Japan, clarify pathogenicity isolated strains. The mortality rate was 10.7%, with deaths occurring mainly underlying comorbidities. Biotypes II and III were most common, strains (64.3%) had multiple amino acid substitutions at Asp-350,...
SUMMARY Heptavalent pneumococcal conjugate vaccine (PCV7) was introduced to Japan in 2010. We investigated the impact of PCV7 on childhood community-acquired pneumonia (CAP) and (PP). Children aged <5 years living Chiba city, Japan, who were admitted hospitals enrolled estimate incidence CAP based mid-year population. PP determined by presence Streptococcus pneumoniae cultured blood and/or sputum samples patients. The S. isolated from patients compared before (April 2008–March 2009) after...
Abstract S treptococcus gallolyticus subsp. pasteurianus was formerly classified as . bovis biotype II /2, which is recognized a rare cause of neonatal sepsis and meningitis. Since the taxonomy classification change, there have not been many reports meningitis due to Moreover, pathogenesis late onset in infants unclear. Here we report case 5‐week‐old infant with preceding diarrhea. S. /2 isolated from blood, cerebrospinal fluid stool, then identified on 16 rRNA gene sequencing. Isolates all...