A5003155821- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Virology and Viral Diseases
- HIV/AIDS Research and Interventions
- Viral Infections and Vectors
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Syphilis Diagnosis and Treatment
- Parvovirus B19 Infection Studies
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Bacteriophages and microbial interactions
- Pneumonia and Respiratory Infections
- SARS-CoV-2 detection and testing
- Dermatological and COVID-19 studies
- Immune responses and vaccinations
- Biosensors and Analytical Detection
- Sex work and related issues
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Pneumocystis jirovecii pneumonia detection and treatment
Osaka University
2015-2025
Osaka Prefectural Institute of Public Health
2017-2025
Yokohama National University
2020
Kyoto City Hospital
2019
Nagoya Medical Center
2019
Osaka University of Pharmaceutical Sciences
2019
Instituut voor Tropische Geneeskunde
2018
Osaka Prefectural Government
2018
University of Florida
2018
Navy and Marine Corps Force Health Protection Command
2018
ABSTRACT Norovirus GII/4 is a leading cause of acute viral gastroenteritis in humans. We examined here how the virus evolves to generate and sustain new epidemics humans, using 199 near-full-length genome sequences 11 segment clones from human stool specimens collected at 19 sites Japan between May 2006 February 2009. Phylogenetic studies demonstrated outbreaks 7 monophyletic subtypes, among which single subtype, termed 2006b, had continually predominated. Phylogenetic-tree,...
Our norovirus (NoV) surveillance group reported a >4-fold increase in NoV infection Japan during the winter of 2006-2007 compared to previous winter. Because was not linked changes system, we suspected emergence new GII/4 epidemic variants. To obtain information on viral changes, conducted full-length genomic analysis. Stool specimens from 55 acute gastroenteritis patients various ages were collected at 11 sites between May 2006 and January 2007. Direct sequencing long PCR products revealed...
Comorbid psychiatric conditions are highly prevalent in individuals with autism spectrum disorder (ASD). Habitual walking may have beneficial effects on mental health; however, it increase social interactions, which difficult for ASD. Hence, the influence of habitual health be limited to without A cross-sectional study 3,823 participants was conducted. Mental defined as a Kessler Psychological Distress Scale score ≥13. Participants ASD diagnosis and an autism-spectrum quotient ≥33 points...
Objectives: To investigate the molecular epidemiology and genetic structure of HIV-1s causing epidemic in Central Myanmar to explore genesis HIV this area. Design: A epidemiological investigation was conducted 1999–2000 city Mandalay among high-risk populations structural features circulating were analyzed. Methods: HIV-1 genotypes 59 specimens screened based on gag (p17) env (C2/V3) regions. Near full-length nucleotide sequences isolates with subtype discordance determined their recombinant...
Abstract Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution G/P types genetic characteristics RVAs circulating Thailand. Between January 2014 September 2016, 1867 stool specimens were collected from adults with six provinces detected 514/1867 (27.5%) specimens. G1P[8] (44.7%) was most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), G9P[8] (1.3%). Unusual G3P[9]...
Abstract Mammalian orthoreovirus (MRV), also known as reovirus, was discovered in the 1950s and became first reported segmented double-stranded RNA virus. MRVs have since been found a variety of animal species, including humans. However, reports on MRV infections are scarce due to rarity their symptomatic occurrence. In Japanese surveillance studies, detected gastrointestinal pathogens 1981, with total 135 records. Osaka City, Japan, isolated 1994 from child meningitis, then 2005 2014...
In Japan, respiratory syncytial virus (RSV) infection generally has occurred during autumn and winter. However, a possible change in the seasonal trend of RSV been observed recently. The current study was conducted to determine whether epidemic season Japan indeed changed significantly. We used expectation-based Poisson scan statistics detect periods with high weekly reported cases (epidemic cluster), clusters were detected between September December 2012-2016 seasons while those July...
Human immunodeficiency virus type 1 (HIV-1) and HIV-2 are genetically distinct viruses that each can cause AIDS. Approximately million people infected with both HIV-1 HIV-2. Additionally, these two use the same receptor coreceptors therefore infect target cell populations. To explore potential genetic interactions, we first examined whether RNAs from be copackaged into virion. We used modified near-full-length contained a green fluorescent protein gene (gfp) different inactivating mutation....
Since the coronavirus disease 2019 (COVID-19) outbreak, laboratory diagnosis has mainly been conducted using reverse-transcription polymerase chain reaction (RT-PCR). Detecting presence of an infectious virus in collected sample is essential to analyze if a person can transmit severe acute respiratory syndrome 2 (SARS-CoV-2). However, there have no quantitative investigations for SARS-CoV-2 clinical samples. Therefore, present study, rapid and simple focus-forming assay...
We have previously shown that HIV-1 env subtypes B′ (a Thai-B cluster within subtype B) and E (CRF01_AE) are distributed in Yangon, the capital city of Myanmar. However, HIV strains from rest country not yet been genetically characterized. In present study, we determined (C2/V3) gag (p17) 25 specimens central Myanmar (Mandalay). Phylogenetic analyses identified 5 C (20%), addition to 10 CRF01_AE (40%) 4 (16%). Interestingly, remaining six (24%) showed discordance between subtypes; three...
Abstract Bejel, an endemic treponematosis caused by infection with Treponema pallidum subspecies endemicum, has not been reported in eastern Asia and the Pacific region. We report local spread of bejel among men who have sex Japan. Spread was complicated venereal syphilis.
Since the first isolation of rubella virus (RuV) in 1962, comprehensive data regarding quantitative evaluation RuV shedding remain unavailable. In this study, we evaluated viral RNA and infectious patients with acute infection. We analyzed 767 specimens, including serum/plasma, peripheral blood mononuclear cells (PBMCs), throat swabs, urine, obtained from 251 rubella. The load presence were determined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR) isolation....
Human norovirus is a predominant etiological agent responsible for acute gastroenteritis across all age groups. Recently, recombinant strains have been reported as the cause of outbreaks in several settings and that mostly belong to GII. However, yet, GI never previously Thailand. The aims this study were investigate genetic recombination genotype diversity children hospitalized with Chiang Mai, Thailand during period seven years from 2015 2021. A total 2,829 stool specimens screened by...
To investigate the nature of recent HIV outbreaks among injecting drug users (IDUs) near Vietnam-China border, we genetically analyzed 24 HIV-positive blood specimens from 2 northern provinces Vietnam (Lang Son and quang Ninh) adjacent to China where IDUs were first detected in late 1996. Genetic subtyping based on gag (p17) env (C2/V3) sequences revealed that CRF01_AE is a principal strain circulating throughout Vietnam, including border. The majority Quang Ninh Lang showed significant...
The infectious activity of coxsackievirus B1 (CV-B1) in Taiwan was high from 2008 to 2010, following an alarming increase severe neonate disease the United States (US). To examine relationship between CV-B1 strains isolated and those other parts world, we performed a phylodynamic study using VP1 partial 3Dpol (414 nt) sequences 22 (1989–2010) compared them worldwide. Phylogenetic trees were constructed by neighbor-joining, maximum likelihood, Bayesian Monte Carlo Markov Chain methods. Four...
The emergence and rapid spread of unusual DS-1-like intergenogroup reassortant rotaviruses having G1/3/8 genotypes have been recently reported from major parts the world (Africa, Asia, Australia, Europe, Americas). During rotavirus surveillance in Thailand, three novel strains possessing G9P[8] genotype (DBM2017-016, DBM2017-203, DBM2018-291) were identified stool specimens diarrheic children. In present study, we determined analyzed full genomes these strains. On full-genomic analysis, all...
Measles is a contagious viral disease causing infant mortality in developing countries without vaccination programs. In Japan, measles was launched 1978, surveillance commenced 1981, and elimination achieved 2015. This due to improved, legally required methods vaccine
HIV infection is a major problem in Indonesia. The number of people living with has been increasing from year to year, especially among injecting drug users (IDUs). Since there were only limited data about molecular epidemiology profiles HIV/AIDS Indonesia, cross-sectional study involving 208 HIV-1-seropositive individuals was conducted 2007 Jakarta. majority participants 16-30 years age (64.9%) and 74.5% male. most frequent risk factor use (IDU) (45.7%) followed by heterosexual transmission...
To determine the distribution of Norovirus (NoV) genotypes in natural river water Thailand, we conducted a genome analysis using next‐generation sequencer. Twenty‐five samples were collected at five different sites Khlong Klon River suburbs Bangkok between August 2013 and December 2014. The partial NoV was detected 15 25 (60·0%). Seven these (46·7%) contained multiple GII genotypes: GII.4, GII.6, GII.17. Our data showed that GII.17 had already emerged as minor population, it became major...
ABSTRACT In September 2016, 140 patients with primary symptoms of sore throat and fever were identified in a school dormitory Osaka, Japan. Epidemiological laboratory investigations determined that these symptomatic conditions from foodborne outbreak group G streptococcus (GGS), GGS being isolated samples patients, cooks, foods. The strain was as Streptococcus dysgalactiae subsp. equisimilis two emm types ( stG652.0 stC36.0 ). causative food, broccoli salad, contaminated the S. , totaling...