A5100658917- Histone Deacetylase Inhibitors Research
- Phytochemistry and Biological Activities
- Essential Oils and Antimicrobial Activity
- Synthesis and biological activity
- HIV/AIDS Research and Interventions
- Natural product bioactivities and synthesis
- HIV, Drug Use, Sexual Risk
- Protein Degradation and Inhibitors
- HIV Research and Treatment
- Plant Pathogens and Fungal Diseases
- Synthesis and Biological Evaluation
- Mosquito-borne diseases and control
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Research studies in Vietnam
- Peptidase Inhibition and Analysis
- Adsorption and biosorption for pollutant removal
- Malaria Research and Control
- RNA and protein synthesis mechanisms
- Quinazolinone synthesis and applications
- Enzyme-mediated dye degradation
- Esophageal and GI Pathology
- HIV/AIDS drug development and treatment
- Plant-Microbe Interactions and Immunity
- Traditional and Medicinal Uses of Annonaceae
Can Tho University
2020-2024
University of Massachusetts Lowell
2024
VA San Diego Healthcare System
2024
University of California, San Diego
2022-2024
108 Military Central Hospital
2024
Mayo Clinic in Arizona
2009-2024
Kyoto Institute of Technology
2024
Vinh Long University of Technology Education
2023
President's Emergency Plan for AIDS Relief
2022
University of Florida
2018
This study presents the process of extracting lignin from sugarcane bagasse collected in Mekong Delta, Vietnam by alkali method.
To ensure the survival and development of organizations in a dynamic competitive environment, managers must seek new approaches to business management (AlEssa & Durugbo, 2021). This study aims examine impact work motivation on employees’ innovative behavior Vietnamese enterprises through mediating factors psychological capital transformational leadership style context digital transformation. A quantitative research method was employed using structural equation modeling (SEM) analysis....
As a dual response to the HIV epidemic and high level of injecting drug use in Vietnam, Ministry Health (MOH) initiated pilot methadone maintenance therapy (MMT) program Hai Phong Ho Chi Minh City (HCMC) early 2009. The objectives were provide evidence on whether MMT could be successfully implemented Vietnam scaled up other localities.
Abstract Kombucha tea is a traditional beverage originating from China and has recently gained popularity worldwide. produced by the fermentation of leaves characterized its beneficial properties varied chemical content during process, which includes organic acids, amino vitamins, minerals, other biologically active compounds. often consumed as health drink to combat obesity inflammation; however, bioactive effects kombucha have not been thoroughly researched. In this study, we reveal...
The U.S. President's Emergency Plan for AIDS Relief (PEPFAR) supports country programs in identifying persons living with HIV infection (PLHIV), providing life-saving treatment, and reducing the spread of countries around world (1,2). CDC used Monitoring, Evaluation, Reporting (MER) data* to assess extent which COVID-19 mitigation strategies affected service delivery across care continuum† globally during first year pandemic. Indicators included number reported HIV-positive test results,...
Epigenetic alterations found in all human cancers are promising targets for anticancer therapy. In this sense, histone deacetylase inhibitors (HDACIs) interesting agents that play an important role the epigenetic regulation of cancer cells. Here, we report 15 novel hydroxamic acid-based with quinazolinone core structures. Five compounds exhibited antiproliferative activity IC50 values 3.4-37.8 µM. Compound 8 a 2-mercaptoquinazolinone cap moiety displayed highest efficacy against MCF-7 For...
To investigate the nature of recent HIV outbreaks among injecting drug users (IDUs) near Vietnam-China border, we genetically analyzed 24 HIV-positive blood specimens from 2 northern provinces Vietnam (Lang Son and quang Ninh) adjacent to China where IDUs were first detected in late 1996. Genetic subtyping based on gag (p17) env (C2/V3) sequences revealed that CRF01_AE is a principal strain circulating throughout Vietnam, including border. The majority Quang Ninh Lang showed significant...
The phytochemical constituents from the roots of Millettia speciosa were investigated by chromatographic isolation, and their chemical structures characterized using MS NMR spectroscopic methods. A total 10 compounds, including six triterpenoids, two flavonoids, phenolic identified M. speciosa. Out isolated eight showed inhibitory effects on NO production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with IC50 values ranging 43.9 to 449.5 µg/mL. Ursane-type triterpenes...
Currently, HIV testing and counseling (HTC) services in Vietnam are primarily funded by international sources. However, funders now planning to withdraw their support the Government of (GVN) is seeking identify domestic funding generate client fees continue services. A clear understanding cost sustain current HTC becoming increasingly important facilitate that can lead making other more affordable sustainable Vietnam. The objectives this analysis were provide a snapshot program costs achieve...
A cap of benzimidazole and a four carbon-chain-containing thioether linker is superior HDAC6 inhibitor to belinostat.
Two series of 2-substituted benzimidazole conjugated 1,3,4-oxadiazole derivatives were designed, synthesized and evaluated for their cytotoxic activities against the three human cancer cell lines (cervical (HeLa), breast (MCF-7) lung (A549)). As results 14 compounds demonstrated consistent to stronger cytotoxicities compared control 5-fluorouracil (5-FU) towards tested including 4c (HeLa); 4b, 4e, 4h, 7i-j, 7m-n, 7s (MCF-7); 7b (MCF-7, A549); 7h (HeLa, MCF-7); 4d, 4i, 7c MCF-7, A549), with...
Multiple myeloma is a deadly cancer that complex and multifactorial disease. In the present study, 12 belinostat derivatives (four resynthesized eight new), HDAC inhibitors, were via either Knoevenagel condensation, or Wittig reaction, Heck reaction. Then an evaluation of antiproliferative activities against cells MOPC-315 was carried out. Amongst them, compound 7f most bioactive with IC50 0.090 ± 0.016 μM, being 3.5-fold more potent than reference (IC50 = 0.318 0.049 μM). Furthermore, we...
The World Health Organization has designated Zika virus (ZIKV) as a dangerous, mosquito-borne flaviviral pathogen that was recently found to be responsible for dramatically increased number of microcephaly cases and other congenital abnormalities in fetuses newborns. There is neither vaccine prevent nor drug treat ZIKA infections, at the present time. Berberine (BBR) promising approved by FDA against dengue virus, BBR derivatives are great interest antiviral development. In this study, we...
Colletotrichum species cause anthracnose in various tropical crops both cultivation and postharvest periods. The current synthetic fungicides to treat sometime show toxic effects for farmers, residues on foods, environmental impacts. In this work, turmeric extract containing curcuminoids was used as an active ingredient formulated into a nanoemulsion control red pepper tomato fruits. nanoparticles (25 %) were successfully prepared by encapsulation using Tween-80 PEG 400 emulsifiers. Out of...
The Zika virus (ZIKV) is believed to cause birth defects, and no anti-ZIKV drugs have been approved by medical organizations date. Starting from antimicrobial lead compounds with a pyrazolo[3,4-d]pyridazine-7-one scaffold, we synthesized 16 derivatives screened their ability interfere ZIKV infection utilizing cell-based phenotypic assay. Of these, five showed significant inhibition of selective index value greater than 4.6. In particular, compound 9b the best activity selectivity 22.4...
Ung thư là một trong những vấn đề sức khỏe nghiêm trọng. Trong nỗ lực liên tục để tìm ra các phương pháp điều trị hiệu quả và an toàn, việc kiếm nguồn dược liệu tự nhiên có khả năng chống ung hướng đi quan nghiên cứu này, tác dụng của 7 loài tảo ven đảo vùng Tây Nam Bộ, bao gồm Padina boryana Thivy, Sargassum sandie, glaucescens, plagiophyllum, Turbinaria ornata, Caulerpa cupressoides, taxifolia đã được tiến hành thử nghiệm khảo sát, với đối tượng tế bào gan (HepG2) vú (MCF7). Tất cả dịch...
Based on the strong activity of belinostat, study synthesized some cinnamoylhydroxamic acid derivatives with aim creating new compounds that have potential to selectively inhibit HDAC contribute cancer treatment. N-hydroxycinnamamide serves as both ZBG and linker group. The orient HDAC2 HDAC8 enzymes by molecular docking. Compound 9a (bearing sulfonamide) exhibited most candidate function enzyme.
HDAC là mục tiêu quan trọng trong liệu pháp điều trị ung thư. Trong nghiên cứu này, bộ dữ bao gồm 32 hợp chất có khả năng chelate với kim loại đã được thiết kế dựa trên khung sườn chalcone-sulfonamide. Docking phân tử thực hiện các nhóm I. Kết quả cho thấy đều thể tương tác mạnh mẽ amino acid tại vị trí hoạt động. Năng lượng liên kết thấp hơn -15 kJ/mol. Đặc biệt, dẫn xuất 20 2‘-hydroxychalcone-sulfonamide thế meta-NO2 hiệu tốt nhất cả ba enzyme HDAC. Đây xem ứng viên tiềm tổng và đánh giá...