A5071878127- Pharmacogenetics and Drug Metabolism
- CRISPR and Genetic Engineering
- Drug Transport and Resistance Mechanisms
- Advanced Wireless Communication Techniques
- COVID-19 Clinical Research Studies
- Cell Adhesion Molecules Research
- Genomics and Phylogenetic Studies
- Cancer-related Molecular Pathways
- Ocular Oncology and Treatments
- SARS-CoV-2 and COVID-19 Research
- Error Correcting Code Techniques
- Neurological diseases and metabolism
- PAPR reduction in OFDM
- Genetically Modified Organisms Research
- Skin and Cellular Biology Research
- Computational Drug Discovery Methods
- Thyroid Cancer Diagnosis and Treatment
- Forensic and Genetic Research
- Chromatin Remodeling and Cancer
- Research studies in Vietnam
- Cancer therapeutics and mechanisms
- Cancer Genomics and Diagnostics
- Immune responses and vaccinations
- Wnt/β-catenin signaling in development and cancer
- Genomics and Rare Diseases
Vietnam Academy of Science and Technology
2016-2025
Clark University
2024-2025
Hung Yen University of Technology and Education
2023
Hanoi University of Science and Technology
2023
University of Transport and Communications
2021-2023
Vietnam National University, Hanoi
2019-2023
University of Science and Technology
2022
Agricultural Genetics Institute
2020-2022
Thai Nguyen University
2022
Vietnam Military Medical University
2021
Intrahepatic cholangiocarcinoma and combined hepatocellular show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying phenotype (LCB). LCB is second in the incidence for cancers with without chronic hepatitis background more aggressive than carcinoma (HCC). To gain insight into its molecular alterations, we performed whole-genome sequencing analysis on 30 LCBs. Here show, genome-wide substitution patterns LCBs developed livers overlapped...
Mapping agricultural fields using high-resolution satellite imagery and deep learning (DL) models has advanced significantly, even in regions with small, irregularly shaped fields. However, effective DL often require large, expensive labeled datasets, which are typically limited to specific years or regions. This restricts the ability create annual maps needed for monitoring, as changes farming practices environmental conditions cause domain shifts between locations. To address this, we...
Metabolic disorders are due to a deficiency of enzymes, which can severely impact health or cause serious complications without treatment. This study aimed identify the molecular causes an infant death who had been hospitalized with complicated problems and metabolism syndrome. Whole-exome sequencing (WES) was used screen pathogenic variants in patient’s genome, followed by examination segregation her parents. The WES analysis identified two homozygous variants, c.[614C>G; 649A>G]...
Vietnam is an important crossroads within Mainland Southeast Asia (MSEA) and a gateway to Island Asia, as such exhibits high levels of ethnolinguistic diversity. However, comparatively few studies have been undertaken the genetic diversity Vietnamese populations. In order gain comprehensive insights into MSEA mtDNA phylogeography, we sequenced 609 complete genomes from individuals belonging five language families (Austroasiatic, Tai-Kadai, Hmong-Mien, Sino-Tibetan Austronesian) analyzed them...
Recent genome-wide association studies (GWAS) identified a number of prostate cancer (PC) susceptibility loci, but most their functional significances are not elucidated. Through our previous GWAS for PC in Japanese population and subsequent resequencing fine mapping, we here that IRX4 (Iroquois homeobox 4), coding Iroquois 4, is causative gene the locus (rs12653946) at chromosome 5p15. expressed specifically heart, quantitative expression analysis revealed significant between genotype...
Insulin or insulin-like growth factor 1 (IGF-1) promotes the activation of phosphoinositide 3 kinase (PI3K)/Akt signaling in immune cells including dendritic (DCs), most potent professional antigen-presenting for naive T cells. Klotho, an anti-aging protein, participates regulation PI3K/Akt signaling, thus Ca2+-dependent migration is reduced klotho-deficient DCs. The present study explored effects insulin/IGF-1 on DC function through klotho expression. To this end, mouse bone marrow were...
Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for association host genetic variants with COVID-19, but data are mostly acquired from Europe. In current work, we explored link between genes (SARS-CoV-2 entry immune system related to COVID-19 sensitivity/severity) ABO blood types whole-exome 200 patients 100 controls in Vietnam. The O type was found be a protective factor that weakens worst outcomes infected individuals. For SARS-CoV-2...
We present a new behavior selection system for human-robot interaction that maps virtual buttons overlaid on the physical environment to robotpsilas behaviors, thereby creating clickable world. The user clicks button and activates associated by briefly illuminating corresponding 3D location with an off-the-shelf green laser pointer. As we have described in previous work, robot can detect this click estimate its using omnidirectional camera pan/tilt stereo camera. In paper, show select...
Certain species within the genus Panax L. (Araliaceae) contain pharmacological precious ginsenosides, also known as ginseng saponins. Species containing these compounds are of high commercial value and thus particular urgency for conservation. However, this genus, identifying that by morphological means is challenging. DNA barcoding one method considered promising level identification. in an evolutionarily complex such Panax, commonly used barcodes nrITS, matK, psbA-trnH, rbcL do not provide...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or dioxin, is commonly considered the most toxic man-made substance. Dioxin exposure impacts human health and diseases, birth defects teratogenesis were frequently observed in children of persons who have been exposed to dioxin. However, impact dioxin on mutation rate trios has not yet elucidated at whole genome level. To identify characterize genetic alterations individuals we performed sequencing (WGS) nine Vietnamese whose fathers In total, 846...
The objective of this study was to determine the prevalence and correlates pretreatment drug resistance (PDR) first-line antiretroviral drugs among people initiating therapy for HIV in Vietnam.Blood collected during November 2009 October 2010 from consecutively ART four purposively selected public outpatient clinics three Vietnamese cities. At each site, recruitment lasted 6-10 months until target sample size (range 120-130 individuals) had been reached. viral load measured 501 samples; 490...
Abstract CYP2D6 genetic variations could result in alteration of enzyme activity, leading to dissimilarity among individuals regard drug metabolism. This study aims detect all variants, allele, and genotype frequencies gene 136 unrelated healthy Kinh Vietnamese volunteers. All single nucleotide variants (SNVs) structural (SVs) were identified by Sanger sequencing multiplex ligation-dependent probe amplification (MLPA) assay. Totally, 30 SNVs 9 SVs including a whole deletion, 8 hybrid...
Alcohol abuse can cause developing cirrhosis, even liver cancer. Several single nucleotide polymorphisms (SNPs) of ADH1B, ADH1C, and ALDH2 genes have been reported to be associated with alcohol alcoholic cirrhosis (ALC). This study investigated the association between three SNPs ADH1B rs1229984, ADH1C rs698, rs671 ALC in people living Northeast region Vietnam.306 male participants were recruited including 206 alcoholics (106 ALC, 100 without ALC) healthy non-alcoholics. Clinical...
Joint source-channel decoding of variable length codes for image and video streaming transmission over unreliable links, such as wireless networks, is a subject increasing interest. We first provide an analysis available redundancy in compressed data produced by some commonly used standardized codecs. Then, we show that significant improvement performance can be achieved when additional properties are taken into consideration. Finally, results improving channels presented.
Link adaptation technology has been introduced in new generation transmission systems, such as 3G and 4G, optimizing both their throughput power consumption. Adaptation of the radio configuration requires information about link quality. The must be exchanged between access point mobile terminal, leading to an associated signaling load, whose amount may decrease system efficiency. A mechanism for reducing designed increase overall capacity (more users, more available bandwidth). paper...
Abstract Background Early‐onset Parkinson's disease (EOPD) refers to that of patients who have been diagnosed or had onset motor symptoms before age 50, accounting for 4% patients. The PRKN and PINK1 genes, both involved in a metabolic pathway, are associated with EOPD. Methods To identify variants EOPD, coding region PARKIN genes 112 healthy individuals were sequenced. Multiplex ligation‐dependent probe amplification kit was used determine EOPD carried mutations genes. Results Conclusion...
Abstract Austronesian (AN) is the second-largest language family in world, particularly widespread Island Southeast Asia (ISEA) and Oceania. In Mainland (MSEA), groups speaking these languages are concentrated highlands of Vietnam. However, our knowledge spread AN-speaking populations MSEA remains limited; particular, it not clear if AN were by demic or cultural diffusion. this study, we present analyze new data consisting complete mitogenomes from 369 individuals 847 Y-chromosomal single...
Abstract Lymphangioleiomyomatosis (LAM) represents a rare, insidiously progressive disease of the pulmonary system, marked by cystic degradation lung tissues leading to respiratory compromise. Pulmonary LAM has been identified as being associated with tuberous sclerosis complex (TSC) in its manifestation (TSC‐LAM), multisystem genetic disorder resulting from mutations either TSC1 or TSC2 genes. Herein, we describe an early 20s female admitted hospital dyspnea, chest pain, hypopigmented...