A5043159528- Genomics and Phylogenetic Studies
- Algorithms and Data Compression
- Machine Learning in Bioinformatics
- Privacy-Preserving Technologies in Data
- RNA and protein synthesis mechanisms
- Gene expression and cancer classification
- Computational Geometry and Mesh Generation
- Natural Language Processing Techniques
- DNA and Biological Computing
- Cancer Genomics and Diagnostics
- Topic Modeling
- Genomics and Chromatin Dynamics
- Protein Structure and Dynamics
- Cryptography and Data Security
- Data Management and Algorithms
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Galaxies: Formation, Evolution, Phenomena
- Advanced Graph Theory Research
- Genetic factors in colorectal cancer
- Bone Tissue Engineering Materials
- Complexity and Algorithms in Graphs
- Network Packet Processing and Optimization
- Optimization and Search Problems
- Orthopaedic implants and arthroplasty
The University of Tokyo
2016-2025
Tokyo Metropolitan University
2025
Chinese National Human Genome Center
2025
Tokyo University of Science
2006-2024
Tokyo Denki University
2024
Kitami Institute of Technology
2019
Osaka Institute of Technology
2018
Kyushu University
2018
Kobe University
2018
Japan Science and Technology Agency
2016
Intrahepatic cholangiocarcinoma and combined hepatocellular show varying degrees of biliary epithelial differentiation, which can be defined as liver cancer displaying phenotype (LCB). LCB is second in the incidence for cancers with without chronic hepatitis background more aggressive than carcinoma (HCC). To gain insight into its molecular alterations, we performed whole-genome sequencing analysis on 30 LCBs. Here show, genome-wide substitution patterns LCBs developed livers overlapped...
The Bio-Dictionary-based Gene Finder was used to reassess the coding potential of AD169 laboratory strain human cytomegalovirus and sequences in Toledo that are missing virus. gene-finder algorithm assesses an ORF encode a protein based on matches database amino acid patterns derived from large collection proteins. score all ORFs with polypeptides ≥50 aa length. As further test for functionality, genomes chimpanzee, rhesus, murine cytomegaloviruses were searched orthologues predicted ORFs....
Variational quantum algorithms have promising applications in noisy intermediate-scale (NISQ) devices. These rely on a classical optimization outer loop that minimizes parameterized circuit function. The variational eigensolver (VQE) is NP-hard, meaning finding the optimal solution infeasible worst-case scenario. One way to address this challenge through parallel of parameters using multiple-parameterized circuits. However, approach unsuitable for cloud-based processing unit utilization due...
To investigate the significance of apatite-wollastonite-containing glass ceramic (AW ceramic) surfaces and biological apatite layer formed on these surfaces, rat marrow cell culture, which shows osteogenic differentiation, was carried out four different culture substrata (control dish, two AW ceramics, each having a surface roughness, an formed. A period 2 weeks in presence beta-glycerophosphate, ascorbic acid, dexamethasone resulted abundant mineralized nodule formations that were positive...
Recent studies applying high-throughput sequencing technologies have identified several recurrently mutated genes and pathways in multiple cancer genomes. However, transcriptional consequences from these genomic alterations genome remain unclear. In this study, we performed integrated comparative analyses of whole genomes transcriptomes 22 hepatitis B virus (HBV)-related hepatocellular carcinomas (HCCs) their matched controls. Comparison sequence (WGS) RNA-Seq revealed much evidence that...
This study aimed to assess and improve the accuracy of a water leakage detection model proposed in preliminary research. The poor results for sound (recall) background noise (specificity) were clarified using countermeasures accordance with each condition. Additionally, frequency amplification range 500–600 Hz, attenuation weak components, band-stop filter used remove 50 Hz component harmonics. Pre-processing was carried out form amplification, removed filter. showed that application...
Abstract Feedback-controlled electromigration (FCE) enables precise regulation of atomic migration by carefully optimizing multiple experimental parameters. However, manually fine-tuning these parameters poses significant challenges. This study investigated the feasibility autonomously fabricating Au junctions through gate-based quantum computing using a noisy intermediate-scale (NISQ) device, which effectively approximates solutions to combinatorial optimization problems. We compared...
Abstract Background Microarray data have been widely utilized for cancer classification. The main characteristic of microarray is “large p and small n” in that contain a number subjects but large genes. It may affect the validity Thus, there pressing demand techniques able to select genes relevant Results This study proposed novel feature (gene) selection method, Iso-GA, Iso-GA hybrids manifold learning algorithm, Isomap, genetic algorithm (GA) account latent nonlinear structure gene...
Nanopore sequencing is a rapidly developing third-generation technology, which can generate long nucleotide reads of molecules within portable device in real-time. Through detecting the change ion currency signals during DNA/RNA fragment's pass through nanopore, genotypes are determined. Currently, accuracy nanopore basecalling has higher error rate than short-read sequencing. utilizing deep neural networks, the-state-of-the art basecallers achieve range from 85% to 95%.In this work, we...
We present new observations of the highest-redshift quasar known, ULAS J1120+0641, redshift $z=7.084$, obtained in optical, at near-, mid-, and far-infrared wavelengths, sub-mm. combine these results with published X-ray radio to create multiwavelength spectral energy distribution (SED), goals measuring bolometric luminosity $L_{\rm bol}$, quantifying respective contributions from AGN star formation. find three components are needed fit data over wavelength range $0.12-1000\,\mu$m:...
Abstract The authors analyze the axisymmetric distribution of stress in an infinite elastic solid containing a flat annular crack under internal pressure which is one three‐part mixed boundary value problems. Assuming that deformation on surface continuous, we may represent it by Fourier series, and reduce problem to solution system algebraic equations. displacement components obtained are given series involving integrals. In particular, integrals plane expressed terms Gaußian hypergeometric...
Abstract Germline mutations in the tumor suppressor gene APC are associated with familial adenomatous polyposis (FAP). Here we applied whole-genome sequencing (WGS) to DNA of a sporadic FAP patient which did not find any pathological by direct sequencing. WGS identified promoter deletion approximately 10 kb encompassing 1B and exon1B . Additional allele-specific expression analysis deep cDNA revealed that reduced mutated allele as low 11.2% total transcripts, suggesting residual mutant...
Gene identification, also known as gene finding or recognition, is among the important problems of molecular biology that have been receiving increasing attention with advent large scale sequencing projects. Previous strategies for solving this problem can be categorized into essentially two schools thought: one school employs sequence composition statistics, whereas other relies on database similarity searches. In paper, we propose a new identification scheme combines best characteristics...
We report a search for z=7 Ly-alpha emitters (LAEs) using custom-made Narrow-Band filter, centered at 9755 Angstroms, with the instrument Suprime-Cam installed Subaru telescope. observed two different fields and obtained sample of 7 which 4 are robust in each field. covering luminosity range 9.10^{42} - 2.10^{43} erg/s comoving volumes ~ 4.10^{5} 4.3.10^{5} Mpc^{3}. From this result, we derived possible z~7 functions full samples subsample objects do not observe, case, any strong evolution...
In genome assembly graphs, motifs such as tips, bubbles, and cross links are studied in order to find sequencing errors understand the nature of genome. Superbubble, a complex generalization was recently proposed an important subgraph class for analyzing graphs. At present, quadratic time algorithm is known. This paper gives O(m log m)-time solve this problem graph with m edges.