A5022481850- Genomics and Phylogenetic Studies
- Forensic and Genetic Research
- Pharmacogenetics and Drug Metabolism
- Drug Transport and Resistance Mechanisms
- Genetic diversity and population structure
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Parkinson's Disease Mechanisms and Treatments
- Cell Adhesion Molecules Research
- Yersinia bacterium, plague, ectoparasites research
- Thyroid Cancer Diagnosis and Treatment
- Carcinogens and Genotoxicity Assessment
- RNA and protein synthesis mechanisms
- Immune responses and vaccinations
- Intraocular Surgery and Lenses
- Plant and Fungal Species Descriptions
- Identification and Quantification in Food
- Pharmacological Effects and Toxicity Studies
- Ocular Oncology and Treatments
- Sperm and Testicular Function
- Lung Cancer Research Studies
- Cancer therapeutics and mechanisms
- Eicosanoids and Hypertension Pharmacology
- Nutrition, Genetics, and Disease
- Malaria Research and Control
Vietnam Academy of Science and Technology
2016-2024
Agricultural Genetics Institute
2020-2022
RIKEN Center for Integrative Medical Sciences
2018
University of Chicago
2006
University of California, San Francisco
2006
North Dakota State University
2000
Vietnam features extensive ethnolinguistic diversity and occupies a key position in Mainland Southeast Asia. Yet, the genetic of remains relatively unexplored, especially with genome-wide data, because previous studies have focused mainly on majority Kinh group. Here, we analyze newly generated single-nucleotide polymorphism data for 21 additional ethnic groups Vietnam, encompassing all five major language families In addition to analyzing allele haplotype sharing within Vietnamese groups,...
Vietnam is an important crossroads within Mainland Southeast Asia (MSEA) and a gateway to Island Asia, as such exhibits high levels of ethnolinguistic diversity. However, comparatively few studies have been undertaken the genetic diversity Vietnamese populations. In order gain comprehensive insights into MSEA mtDNA phylogeography, we sequenced 609 complete genomes from individuals belonging five language families (Austroasiatic, Tai-Kadai, Hmong-Mien, Sino-Tibetan Austronesian) analyzed them...
Abstract Vietnam exhibits great cultural and linguistic diversity, yet the genetic history of Vietnamese populations remains poorly understood. Previous studies focused mostly on majority Kinh group, thus diversity many other groups has not been investigated. Here we analyze complete mtDNA genome sequences ~2.3 Mb male-specific portion Y chromosome from 16 minority populations, encompassing all five language families present in Vietnam. We find highly variable levels within between that do...
Since the emergence and rapid transmission of SARS-CoV-2, numerous scientific reports have searched for association host genetic variants with COVID-19, but data are mostly acquired from Europe. In current work, we explored link between genes (SARS-CoV-2 entry immune system related to COVID-19 sensitivity/severity) ABO blood types whole-exome 200 patients 100 controls in Vietnam. The O type was found be a protective factor that weakens worst outcomes infected individuals. For SARS-CoV-2...
Certain species within the genus Panax L. (Araliaceae) contain pharmacological precious ginsenosides, also known as ginseng saponins. Species containing these compounds are of high commercial value and thus particular urgency for conservation. However, this genus, identifying that by morphological means is challenging. DNA barcoding one method considered promising level identification. in an evolutionarily complex such Panax, commonly used barcodes nrITS, matK, psbA-trnH, rbcL do not provide...
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) or dioxin, is commonly considered the most toxic man-made substance. Dioxin exposure impacts human health and diseases, birth defects teratogenesis were frequently observed in children of persons who have been exposed to dioxin. However, impact dioxin on mutation rate trios has not yet elucidated at whole genome level. To identify characterize genetic alterations individuals we performed sequencing (WGS) nine Vietnamese whose fathers In total, 846...
Abstract CYP2D6 genetic variations could result in alteration of enzyme activity, leading to dissimilarity among individuals regard drug metabolism. This study aims detect all variants, allele, and genotype frequencies gene 136 unrelated healthy Kinh Vietnamese volunteers. All single nucleotide variants (SNVs) structural (SVs) were identified by Sanger sequencing multiplex ligation-dependent probe amplification (MLPA) assay. Totally, 30 SNVs 9 SVs including a whole deletion, 8 hybrid...
Antioxidant genes, such as superoxide dismutase (SOD), catalase (CAT), and nitric oxide synthase (NOS), play critical roles in spermatogenesis sperm functions. Polymorphisms of antioxidant genes have been shown to be strongly associated with quality which affects male fertility.To investigate the association gene polymorphisms infertility Vietnamese men, this case-control study, using Sanger sequencing, we genotyped four variants SOD1:7958G>A, SOD2:c.47T>C, CAT:-262C>T, NOS3:-786C>T.We...
The consequences of pain in early onset Parkinson's disease (EOPD) remain under appreciated even though may exert an increasingly negative impact on patient quality life as motor and non-motor symptoms worsen.In this prospective study, we investigate the prevalence severity 135 Vietnamese patients with EOPD from three medical centers using King's PD Pain Scale (KPPS), Mini Mental Status Exam (MMSE), Unified Disease Rating (UPDRS) Non-Motor Symptoms (NMSS).Pain was reported by 79.3%. most...
Abstract Background Early‐onset Parkinson's disease (EOPD) refers to that of patients who have been diagnosed or had onset motor symptoms before age 50, accounting for 4% patients. The PRKN and PINK1 genes, both involved in a metabolic pathway, are associated with EOPD. Methods To identify variants EOPD, coding region PARKIN genes 112 healthy individuals were sequenced. Multiplex ligation‐dependent probe amplification kit was used determine EOPD carried mutations genes. Results Conclusion...
Background and Objectives: Drug resistant epilepsy (DRE) is a major hurdle in epilepsy, which hinders clinical care, patients’ management treatment outcomes. DRE may partially result from genetic variants that alter proteins responsible for drug targets transporters the brain. We aimed to examine relationship between SCN1A, GABRA1 ABCB1 polymorphism response children Vietnam. Materials Methods: In total, 213 diagnosed with were recruited this study (101 responsive 112 resistant). Sanger...
Background and objective: Gout is a common form of inflammatory arthritis caused by the crystallization uric acid. Previous studies have demonstrated that genetic predisposition gout varies in different ethnic populations. However association study variants with remains unknown Vietnamese population. Our aimed to assess relationship between polymorphisms ABCG2 SLC22A12 susceptibility Vietnamese. Materials methods: Genomic DNA was extracted from blood total 170 patients 351 healthy controls....
Background: Genetic polymorphism of CYP2C19 has been shown to affect enzyme activity and thereby contribute inter-individual variability in drug metabolism response. The complete genetic variation Vietnam still remains obscure even though data common alleles Vietnamese Kinh have reported.Aim: To establish the extent Vietnamese.Subjects methods: promoter all nine exons 100 healthy unrelated subjects were sequenced. Additionally, variants, *2, *3 *17 analysed by RFLP-PCR 275 four minor ethnic...
Abstract Austronesian (AN) is the second-largest language family in world, particularly widespread Island Southeast Asia (ISEA) and Oceania. In Mainland (MSEA), groups speaking these languages are concentrated highlands of Vietnam. However, our knowledge spread AN-speaking populations MSEA remains limited; particular, it not clear if AN were by demic or cultural diffusion. this study, we present analyze new data consisting complete mitogenomes from 369 individuals 847 Y-chromosomal single...
Although it has been a half-century since dioxin-contaminated herbicides were used to defoliate the landscape during Vietnam War, dioxin contamination “hotspots” still remain in Vietnam. Environmental and health impacts of these hotspots need be evaluated. Intellectual disability (ID) is one diseases found children people exposed herbicides. This study aims identify genetic alterations patient whose family lived hotspot. The patient’s father had highly elevated concentration. He was affected...
13072 Background: MRP2, encoded by ABCC2, is an ATP-binding cassette transporter that plays a critical role in the biliary elimination of various drugs and xenobiotics. Although SNPs this gene have been identified reported, their functions are not fully understood. T he purpose study was to evaluate effect polymorphisms/haplotypes ABCC2 on its mRNA expression human liver. Methods: Two hundred liver samples were genotyped for following polymorphisms: −1549G>A, −1019A>G, −24C>T,...