A5090977989- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Liver Disease Diagnosis and Treatment
- Metabolomics and Mass Spectrometry Studies
- Cardiovascular Health and Disease Prevention
- Peroxisome Proliferator-Activated Receptors
- Fatty Acid Research and Health
- Diet and metabolism studies
- Immune Cell Function and Interaction
- Cardiovascular Disease and Adiposity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Thyroid Disorders and Treatments
- Retinoids in leukemia and cellular processes
- Cancer, Lipids, and Metabolism
- Antioxidant Activity and Oxidative Stress
- Pharmacogenetics and Drug Metabolism
- Hormonal Regulation and Hypertension
- Regulation of Appetite and Obesity
- Diet, Metabolism, and Disease
- Advanced Glycation End Products research
- Gut microbiota and health
- Thyroid Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Probiotics and Fermented Foods
- Metabolism and Genetic Disorders
Korea University
2009-2025
Inha University
2023-2024
Dankook University
2024
Institute of Biomedical Science
2023
Yonsei University
2016-2022
Soonchunhyang University
2020-2021
Bucheon University
2021
Hanyang University
2016-2019
Tehran University of Medical Sciences
2019
Catholic University of Daegu
2019
The aim of this study was to investigate the impact consuming dairy yogurt containing Lactobacillus paracasei ssp. (L. paracasei), Bifidobacterium animalis lactis (B. lactis) and heat-treated plantarum plantarum) on immune function. A randomized, open-label, placebo-controlled conducted 200 nondiabetic subjects. Over a twelve-week period, test group consumed probiotics each day, whereas placebo milk. Natural killer (NK) cell activity, interleukin (IL)-12 immunoglobulin (Ig) G1 levels were...
SARS-CoV-2 variants evade immunity despite vaccination with prototype COVID-19 vaccines or previous infection. The 2019nCoV-311 (part 2) study is evaluating immune responses after two booster doses of a vaccine containing the omicron BA.5 subvariant spike protein in adults previously vaccinated mRNA vaccine. This interim analysis reports on day 28 immunogenicity and safety outcomes one dose.
BackgroundAntithyroid drug (ATD) treatment is the preferred initial for Graves' disease (GD) in South Korea, despite higher failure rates than radioactive iodine (RAI) therapy or thyroidectomy. This study aimed to evaluate incidence of associated with primary modalities GD real-world practice. MethodsWe included 452,001 patients diagnosed between 2004 and 2020 from Korean National Health Insurance Service-National Information Database. Treatment was defined as switching ATD, RAI,...
Lipocalin family proteins, including adipocyte fatty acid-binding protein (A-FABP), lipocalin-2 and retinol-binding 4 (RBP4), have recently been identified as novel adipokines associated with obesity, type 2 diabetes the metabolic syndrome. We evaluated effect of exercise training on lipocalin proteins inflammatory markers.Thirty obese Korean women 15 age-matched nonobese control subjects were studied.Concentrations compared between before 3 months after an programme consisting aerobic (45...
Abstract In the prospective Korean Cancer Prevention Study-II (KCPS-II), we investigated application of metabolomics to differentiate subjects with incident hepatocellular carcinoma (HCC group) from who remained free cancer (control during a mean follow-up period 7 years aim identifying valuable metabolic biomarkers for HCC. We used baseline serum samples 75 HCC and 134 age- gender-matched cancer-free subjects. Serum profiles associated incidence were via analysis. Compared control group,...
Probiotic supplementation increased the levels of C8:1, C14:1, C10, and C12:1 acylcarnitines, these increases were correlated with a decrease in body weight, fat percentage, mass L1 subcutaneous area.
Using metabolomics technique to analyze the response a dietary intervention generates valuable information concerning effects of prescribed diet on metabolic regulation. To determine whether low calorie (LCD)-induced weight reduction causes changes in plasma metabolites and characteristics. Overweight subjects consumed LCD (n = 47) or maintenance (control, n 50) randomized, controlled design study with 12-week clinical period. Plasma samples were analyzed using an UPLC-LTQ-Orbitrap MS. The...
The inflammatory status of atherosclerotic lesions is a major factor triggering acute cardiovascular events. Growing evidence has shown that adipocyte fatty acid-binding protein (A-FABP) an important role in the development atherosclerosis.The objective study was to determine association between circulating A-FABP levels with vascular inflammation as measured using [(18)F]-fluorodeoxyglucose (FDG) positron emission tomography (PET), which novel imaging technique for noninvasive measurement...
We examined the severity of vascular inflammation in healthy individuals without hyperlipidemia but with elevated high-sensitivity C-reactive protein (hsCRP) using <sup>18</sup>F-FDG PET, which is a promising imaging technique for assessment within atherosclerotic plaques. <b>Methods</b><b>:</b> Vascular carotid arterial wall, represented as target-to-background ratio (TBR), was measured PET 120 subjects history cardiovascular diseases. <b>Results:</b> Subjects high hsCRP (≥2 mg/L) and low...
Pulse wave velocity (PWV) is thought to have different relationships with metabolic syndrome (MS) components, inflammatory markers, and oxidative stress, according age. However, age-specific determinants of PWV not yet been studied. We investigated age-dependent among MS stress.A total 4,318 subjects were divided into 4 groups: 19-34 y (n=687), 35-44 (n=1,413), 45-54 (n=1,384), 55-79 (n=834). brachial-ankle (baPWV), high-sensitivity C-reactive protein (hs-CRP), stress markers measured.There...
Liver cirrhosis (LC) is the final usual outcome of liver damage induced by various chronic diseases. Because asymptomatic nature LC, it usually diagnosed at late and advanced stages, patients are easy to miss best timing for treatment. Thus, early detection LC needed. In prospective Korean Cancer Prevention Study-II (K-II), we aimed identify valuable biomarkers using metabolomics distinguish subjects with incident (LC group) from free (control during a mean 7-year follow-up period. Metabolic...
Abstract Background/Objectives The objective of this study was to evaluate the effect supplementation with a Jerusalem artichoke and fermented soybean powder mixture on blood glucose oxidative stress levels. Subjects/Methods This randomized, double-blinded, placebo-controlled conducted 60 subjects impaired fasting (IFG), tolerance (IGT), or newly diagnosed type 2 diabetes. were randomly assigned either group that ingested 40 g (19.45 each) daily received placebo for 12 weeks. Paired t -test...
Schisandra fruits (Schisandraceae) are often used in traditional medicine and can be taken concomitantly with conventional medicine. In this study, the effects of dibenzocyclooctadiene lignans from Schizandra chinensis on P-gp-mediated efflux were examined to investigate a possible interaction P-gp substrates. The cellular accumulation rhodamine-123 Caco-2 cells was measured 12 lignans. Most compounds resulted slight or moderate increases rhodamin-123 uptake, indicating their inhibitory...
Visceral fat accumulation in overweight status has been resulted changes of fatty acid profiles. The acids profiles can be altered by desaturase; the activity which is highly associated with obesity and other metabolic diseases. We hypothesized that composition, desaturase activity, visceral are interrelated. Thus, aim this study was to investigate association between increased area alterations plasma profile subjects different amounts fat.Healthy (25.0 kg/m2 ≤ BMI < 30 kg/m2, n=232) were...
Objective To screen the metabolomes of both overweight subjects with low visceral fat area (LFO) and high (HFO) to identify potential metabolites that are associated different metabolic characteristics. Methods The characteristics 112 (25 kg/m 2 ≤ BMI < 30 ) Korean individuals aged 65 years were examined. Plasma metabolomic profiling HFO [visceral (VFA) at L4 ≥ 100 cm ] LFO (L4 VFA <100 matched for age, gender, was performed. Results showed higher L1 than subjects. group blood...
Active metabolism of peripheral blood mononuclear cells (PBMC) could suggest their suitability for metabolomics studies. This study examined whether reductions in PBMCs and plasma lipoprotein-associated phospholipase A2 (Lp-PLA2) activities induced by dietary intervention affected the overall metabolic profiles PBMC plasma.Eighty nonobese subjects aged 40-70 years (18.5 ≤ BMI < 30 kg/m(2)) with prediabetes or newly-diagnosed type-2 diabetes were assigned to consume either usual refined-rice...
Background/Aims: Obstructive sleep apnea (OSA) is associated with an increased risk of obesity and non-alcoholic fatty liver disease (NAFLD), but it remains unclear whether the NAFLD independently related to OSA regardless visceral obesity. Thus, aim present study was examine alone or in combination excessive daytime sleepiness (EDS) short duration independent fat Korean adults. Methods: A total 621 participants were selected from Genome Epidemiology Study (KoGES). The abdominal area (VFA)...
Hypertriglyceridemia is recognized as an independent risk factor for coronary artery disease. The apolipoprotein A5 gene (APOA5) a key regulator of triglyceride levels. We aimed to evaluate the associations single nucleotide polymorphisms (SNPs) in APOA5, including -1131T>C and c.553G>T, with hypertriglyceridemia, apoA5 concentrations, atherogenic LDL cholesterol levels, arterial stiffness hypertriglyceridemic patients. study population included 599 patients (case) 1,549 untreated...