Chronotype is a trait determining individual circadian preference in behavioral and biological rhythm relative to external light-dark cycle. However, little known about the relationship between chronotype metabolic disorders. The aim of this study was examine whether late related abnormalities body composition middle-aged adults, independent sleep duration lifestyle. A total 1620 participants aged 47–59 years were recruited from Korean Genome Epidemiology Study. assessed by...

The prevalence of obesity has been rapidly increasing worldwide over the last several decades and become a major health problem in developed countries. brain, especially hypothalamus, plays key role control food intake by sensing metabolic signals from peripheral organs modulating feeding behaviors. To accomplish these important roles, hypothalamus communicates with other brain areas such as brainstem reward-related limbic pathways. adipocyte-derived hormone leptin pancreatic β-cell-derived...

The association of metabolic syndrome (MetS) with the development Parkinson disease (PD) is currently unclear. We sought to determine whether MetS and its components are associated risk incident PD using large-scale cohort data for whole South Korean population.Health checkup 17,163,560 individuals aged ≥40 years provided by National Health Insurance Service (NHIS) Korea between January 1, 2009, December 31, 2012, were included, participants followed up until 2015. mean follow-up duration...

The majority of mammalian cells have nonmotile primary cilia on their surface that act as antenna-like sensory organelles. Genetic defects result in ciliary dysfunction are associated with obesity humans and rodents, which suggests functional important for controlling energy balance. Here we demonstrated neuronal lengths were selectively reduced hypothalami obese mice leptin deficiency resistance. Treatment N1 hypothalamic neuron stimulated assembly via inhibition the tumor suppressors PTEN...

With the emergence of various classes blood glucose-lowering agents, choosing appropriate drug for each patient is emphasized in diabetes management. Among incretin-based drugs, glucagon-like peptide 1 (GLP-1) receptor agonists are a promising therapeutic option patients with diabetic kidney disease (DKD). Several cardiovascular outcome trials have demonstrated that GLP-1 beneficial effects on cardiorenal outcomes beyond their type 2 mellitus (T2DM). The renal protective likely result from...

BackgroundAntithyroid drug (ATD) treatment is the preferred initial for Graves' disease (GD) in South Korea, despite higher failure rates than radioactive iodine (RAI) therapy or thyroidectomy. This study aimed to evaluate incidence of associated with primary modalities GD real-world practice. MethodsWe included 452,001 patients diagnosed between 2004 and 2020 from Korean National Health Insurance Service-National Information Database. Treatment was defined as switching ATD, RAI,...

This study investigates health behaviors, health-related quality of life (HRQOL) and sleep among chronotypes in a community-based sample (n = 2,976). Analysis covariance indicated evening types (E-types) had significantly higher percentage current smokers more sleep-interfering behaviors compared to intermediate morning (M-type), also lower physical activity disturbance M-types. E-types worse mental HRQOL both chronotypes, Exploratory analyses consumed caffeinated beverages at night, smoked...

Background Diabetic nephropathy is a leading cause of end stage renal disease and associated with an increased risk cardiovascular mortality. It manifests as albuminuria or impaired glomerular filtration rate (GFR), the prevalence diabetic varies ethnicity. The its determinants in Korean adults have not previously been studied at national level. This cross-sectional study was undertaken to ascertain chronic kidney (CKD) patients diabetes. Methods Korea National Health Nutrition Examination...

Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent antioxidant and regulates glucose lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) its protein, fetuin-A (FETUA), are one of hepatokines known to be associated with insulin resistance type 2 diabetes. aim this study was determine whether melatonin improves hepatic steatosis FETUA-dependent manner. In HepG2 cells treated 300 μmol/L palmitic acid,...

The reported effects of a metabolically healthy obese (MHO) phenotype on diabetes and cardiovascular disease (CVD) risk are contradictory. Within the context population-based cohort study, we aimed to investigate long-term an MHO status for development CVD, whether consistency this or age affected cardiometabolic outcomes. We recruited 7588 subjects without aged 40 69 years at baseline examination, from Korean Genome Epidemiology Study, followed-up these 10 biennially. Participants were...

Previous research has shown that the brain is an important target of diabetic complications. Since regions are interconnected to form a large-scale neural network, we investigated whether severe hyperglycemia affects topology network in people with type 2 diabetes. Twenty middle-aged (average age: 54 years) individuals poorly controlled diabetes (HbA1c: 8.9−14.6%, 74−136 mmol/mol) and 20 age-, sex-, education-matched healthy volunteers were recruited. Graph theoretic analysis was performed...

Diabetes mellitus is associated with an increased risk of dementia. We aimed to comprehensively analyze the incidence and factors for dementia young-onset (YOD) in diabetic patients Korea using National Health Insurance Service data.Between January 1, 2009 December 31, 2012, a total 1,917,702 participants diabetes were included followed until date diagnosis or 2015. evaluated all dementia, Alzheimer's disease (AD), vascular (VaD) by Cox proportional hazards analyses. also compared impact on...

Abstract Background The roles of chronic kidney disease and proteinuria in the development Parkinson's have not been widely studied. objective this study was to examine associations renal dysfunction with risk PD older adults using cohort data whole South Korean population. Methods We included 3,580,435 individuals aged ≥65 years who had undergone health checkups provided by National Health Insurance Service Korea between 2009 2012 were followed until 2015. Multivariable Cox proportional...

Abstract Background Previous research regarding long-term glucose variability over several years which is an emerging indicator of glycemic control in diabetes showed limitations. We investigated whether fasting plasma (FG) can predict the development stroke, myocardial infarction (MI), and all-cause mortality patients with diabetes. Methods This a retrospective cohort study using data provided by Korean National Health Insurance Corporation. A total 624,237 Koreans ≥ 20 old who had...

We aimed to investigate the moderating effects of obesity, age, and sex on association between sleep duration development diabetes in Asians.We analyzed data from a cohort Korean Genome Epidemiology Study conducted 2001 2020. After excluding shift workers those with at baseline, 7,407 participants were stratified into three groups according duration: ≤5 hours/night, >5 7 hours/night (reference), >7 hours/night. The Cox proportional hazards analyses used calculate hazard ratios (HRs) 95%...

Abstract Aims We aimed to examine the impact of gout on cardiovascular disease (CVD) and mortality risk in patients with type 2 diabetes explore whether chronic kidney (CKD) modifies this association. Materials Methods Using Korean National Health Insurance Service database, 757 378 individuals were classified into CKD − Gout , + groups. Cox proportional hazard models used assess myocardial infarction (MI), ischemic stroke, mortality, after adjusting for cardiometabolic factors. Results Over...

Background: The effects of glomerular hyperfiltration (GHF) on cardiovascular disease (CVD) risk in patients with type 2 diabetes mellitus (T2DM) were explored. Methods: This retrospective cohort study enrolled 1,952,053 from the Korean National Health Insurance Service database between 2015 and 2016. Based age- sex-specific estimated filtration rate (eGFR) percentiles, classified into five groups: <5 (low filtration), 5–40, 40–60, 60–95, >95 (GHF). Patients incident (myocardial...

Abstract Aims Metabolic dysfunction‐associated fatty liver disease (MAFLD) has recently been proposed to describe the hepatic steatosis associated with metabolic abnormalities. Substantial evidence shown that may be linked cognitive impairment and dementia. This study aimed clarify association between MAFLD brain structural changes. Materials Methods We analysed data from 2155 participants both baseline 4‐year follow‐up magnetic resonance images neuropsychological measures Ansan cohort of...

Numerous researches have revealed a correlation between dietary factors and the development of constipation. This study aimed to investigate association oxidative balance score (DOBS) A cross-sectional was conducted by us based on National Health Nutrition Examination Survey (NHANES) from 2005 2010 including 31,034 individuals who completed constipation questionnaire. The DOBS calculated 16 factors, containing 14 antioxidants two prooxidants. Multiple logistic regression restricted cubic...

Muscle quality, represented by myosteatosis, is recognized as an important factor in sarcopenia. In this study, we aimed to determine the associations between muscle strength and physical performance among elderly South Korean population. We included 1440 participants (mean age 62.7 ± 6.2 years) from Genome Epidemiology Study (KoGES). Based on computed tomography attenuation of mid-thigh imaging, total area (TMA), normal-attenuation (NAMA), low-attenuation (LAMA) inter-intramuscular adipose...

Abstract This study investigated the effects of diabetes and antidiabetic medications on risk pancreatic cancer(PaC). We extracted data Koreans with newly diagnosed selected age- sex-matched controls provided by National Health Insurance Corporation. Incident PaC was defined as a new registration in Korea Central Cancer Registry under ICD-10 C25 admission history until 2015. During 19,429,617.1 person-years, 8,589 PaCs were identified 1,005,409 subjects for group 4,021,636 control group. The...

Increased glycemic variability (GV) is an independent risk factor for cardiovascular complications in patients with diabetes. We evaluated the of future development disease (CVD) and death according to GV a general population without diabetes.We used National Health Insurance Service, providing population-based, nationwide database Koreans. included individuals diabetes who underwent glucose measurement at least 3 times during 2002 2006. was calculated as standard deviation (SD) fasting...

Gamma-glutamyltransferase (GGT) has been reported to be useful in predicting cardiovascular disease. Arterial stiffness measured by brachial-ankle pulse wave velocity (baPWV) is not only a marker of vascular damage but significant predictor events. Gender difference the association between GGT and baPWV. We assessed, therefore, baPWV large population determined whether there was gender difference.This cross-sectional study conducted at Asan Medical Centre, Seoul, Republic Korea.Serum GGT,...