A5050352398- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Cancer Genomics and Diagnostics
- Global Cancer Incidence and Screening
- Pancreatic and Hepatic Oncology Research
- Statistical Methods and Inference
- Statistical Methods and Bayesian Inference
- Statistical Methods in Clinical Trials
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Renal and related cancers
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Head and Neck Cancer Studies
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Renal cell carcinoma treatment
- Neuroendocrine Tumor Research Advances
- Cancer Risks and Factors
- Cerebrovascular and Carotid Artery Diseases
- Advanced Causal Inference Techniques
- Genetic factors in colorectal cancer
- Bayesian Methods and Mixture Models
- Cholangiocarcinoma and Gallbladder Cancer Studies
University of Virginia
2023-2025
Tongji University
2025
First Affiliated Hospital of Anhui Medical University
2025
Shanghai Tenth People's Hospital
2025
The University of Texas Southwestern Medical Center
2014-2023
Southwestern Medical Center
2017-2023
Harold C. Simmons Comprehensive Cancer Center
2018-2023
Nanjing University of Chinese Medicine
2022-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Purpose To compare overall survival between patients who received neoadjuvant therapy (NAT) followed by resection and those upfront (UR)-as well as a subgroup of UR also adjuvant therapy-for early-stage resectable pancreatic adenocarcinoma. Patients Methods Adult with resected, clinical stage I or II adenocarcinoma the head pancreas were identified in National Cancer Database from 2006 to 2012. underwent NAT curative-intent matched propensity score whose tumors resected upfront. Overall was...
Abstract Genomic profiling can provide prognostic and predictive information to guide clinical care. Biomarkers that reliably predict patient response chemotherapy immune checkpoint inhibition in gastric cancer are lacking. In this retrospective analysis, we use our machine learning algorithm NTriPath identify a gastric-cancer specific 32-gene signature. Using unsupervised clustering on expression levels of these 32 genes tumors from 567 patients, four molecular subtypes for survival. We...
Adjuvant chemotherapy (AC) in patients with rectal cancer pathologic complete response following neoadjuvant chemoradiotherapy (nCRT) and resection is recommended by treatment guidelines. However, its role this setting equivocal because data supporting benefits are lacking.To compare the overall survival (OS) between AC postoperative observation (OB) nCRT resection.We identified a cohort of pathological (ypT0N0) after National Cancer Database 2006 2012. Patients who received were compared OB...
Abstract Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms which cancer exploit the regulatory machinery acquire therapy resistance remain poorly understood. We identified zinc finger protein 397 (ZNF397) as a bona fide coactivator of androgen receptor (AR), essential for transcriptional program governing AR-driven luminal lineage. ZNF397...
Abstract The critical roles of CD4 + T cells have been understudied for cancer vaccines. Here we report long-term clinical outcomes a randomized multicenter phase II trial (NCT00118274), where patients with high-risk melanoma received multipeptide vaccine targeting CD8 (12MP) and were to receive either two vaccines (helper) cells: 6MHP (6 melanoma-specific helper peptides), or tet (a nonspecific peptide from tetanus toxoid). Cyclophosphamide (Cy) pre-treatment was also assessed. Primary cell...
Split-mouth designs are frequently used in dental clinical research, where a mouth is divided into two or more experimental segments that randomly assigned to different treatments. It has the distinct advantage of removing lot inter-subject variability from estimated treatment effect. Methods statistical analyses for split-mouth design have been well developed. However, little work available on sample size consideration at phase trial, although many researchers pointed out can only be...
Numerous researches have revealed a correlation between dietary factors and the development of constipation. This study aimed to investigate association oxidative balance score (DOBS) A cross-sectional was conducted by us based on National Health Nutrition Examination Survey (NHANES) from 2005 2010 including 31,034 individuals who completed constipation questionnaire. The DOBS calculated 16 factors, containing 14 antioxidants two prooxidants. Multiple logistic regression restricted cubic...
Anaplastic lymphoma kinase (ALK) is prominently expressed in numerous malignant tumors, which lead to aberrant tumor proliferation, invasion and metastasis. Ceritinib (LDK378), as second-generation targeted drugs, has been used treat advanced ALK-positive non-small cell lung cancer (NSCLC). Herein, we sought develop a novel ALK-positron emission tomography/magnetic resonance (PET/MR) tracer 68Ga-DOTA-CTB (68Ga labeled ceritinib) based on ceritinib scaffold monitor the ALK expression levels...
The association between hospital volume and outcome following high-risk low cancer surgery is well documented. However, this not understood in patients undergoing non-surgical therapies. We explored a cohort of newly diagnosed with hepatocellular carcinoma (HCC).Data from the 2000 through 2011 Texas Cancer Registry were used to study adults HCC (17,231 322 hospitals). Hospital was stratified into high using Contal's outcome-based method. A multivariable Cox regression shared frailty evaluate...
Coronavirus disease 2019 (COVID-19) is associated with high perioperative morbidity and mortality among adults. The incidence severity of anesthetic complications in children severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) unknown. We hypothesized that there would be an increased intra- postoperative SARS-CoV-2 infection as compared to those negative testing. conducted a retrospective cohort study analyzing for <18 years age who underwent anesthesia between April 28 September...
Background: HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC) demonstrates favorable outcomes compared to HPV-negative SCC, but distant metastases (DM) still occur. The pattern of DM in HPV+ HNSCC is unclear. Methods: 1,494 patients were treated from 2006 2012. Recurrence time metastatic sites (Group 1) with HPV-negative/unknown cancers arising the hypopharynx, larynx, or glottis 2) as well theoral cavity, oropharynx, hard palate, tonsil 3). Results: 7/109 (6.4%) developed DM....
In biomedical studies, ordered bivariate survival data are frequently encountered when failure events used as outcomes to identify the progression of a disease. cancer interest could be focused on times, for example, time from birth onset and death. This paper considers sampling scheme, termed interval sampling, in which first event is identified within calendar interval, initiating can retrospectively confirmed occurrence second observed subject right censoring. application, initiating,...
Among Latinas with breast cancer, residence in an ethnic enclave may be associated survival. However, findings from prior studies are inconsistent.The authors conducted parallel analyses of California and Texas cancer registry data for adult (aged ≥18 years) who were diagnosed invasive 1996 to 2005, follow-up through 2014. Existing indices applied tract-level 2000 US Census used measure Latinx enclaves neighborhood socioeconomic status (nSES). Multivariable Cox proportional hazard models fit...
Racial and ethnic disparities have been reported for HCC prognosis, although few studies fully account clinically important factors social determinants of health, including neighborhood socioeconomic status.
In many biomedical applications, interest focuses on the occurrence of two or more consecutive failure events and relationship between event times, such as age disease onset residual lifetime. Bivariate survival data with interval sampling arise frequently when registries surveillance systems collect based incidence occurring within a specific calendar time interval. The initial is then retrospectively confirmed subsequent may be observed during follow-up. life history studies, could...