A5085303062- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- AI in cancer detection
- Breast Lesions and Carcinomas
- Chemokine receptors and signaling
- Nonmelanoma Skin Cancer Studies
- Melanoma and MAPK Pathways
- Economic and Financial Impacts of Cancer
- BRCA gene mutations in cancer
- Diversity and Career in Medicine
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- Advances in Oncology and Radiotherapy
- Radiomics and Machine Learning in Medical Imaging
- Health and Medical Research Impacts
- Global Cancer Incidence and Screening
- Patient Dignity and Privacy
- Infrared Thermography in Medicine
- Patient-Provider Communication in Healthcare
- Digital Imaging in Medicine
- Full-Duplex Wireless Communications
Lynn University
2025
University of Virginia
2010-2024
University of Virginia Health System
2008-2022
University of Virginia Cancer Center
2021-2022
Martha Jefferson Hospital
2015
Memorial Sloan Kettering Cancer Center
2013-2014
University Medical Center Groningen
2014
Yale University
2014
Salem VA Medical Center
2009
Immune cells infiltrating the microenvironment of melanoma metastases may either limit or promote tumor progression, but characteristics that distinguish these effects are obscure. In this study, we systematically evaluated composition and organization immune infiltrated in human patients. Three histologic patterns cell infiltration were identified, designated immunotypes A, B, C. Immunotype A was characterized by no infiltrate. B limited only to regions proximal intratumoral blood vessels....
Abstract The critical roles of CD4 + T cells have been understudied for cancer vaccines. Here we report long-term clinical outcomes a randomized multicenter phase II trial (NCT00118274), where patients with high-risk melanoma received multipeptide vaccine targeting CD8 (12MP) and were to receive either two vaccines (helper) cells: 6MHP (6 melanoma-specific helper peptides), or tet (a nonspecific peptide from tetanus toxoid). Cyclophosphamide (Cy) pre-treatment was also assessed. Primary cell...
Merkel cell carcinoma (MCC) is a rare, aggressive neuroendocrine cutaneous malignancy. Current recommendations include offering regional lymph node evaluation by either sentinel biopsy (SLNB) or complete dissection (CLND) to all patients with MCC; however, we hypothesized cohort of low-risk may exist for whom nodal metastasis would be unlikely.A retrospective review the Department Veterans Affairs national health care database was performed. Patients undergoing resection primary MCC were...
Immune-mediated cancer regression requires tumor infiltration by antigen-specific effector T cells, but lymphocytes are commonly sparse in melanoma metastases. Activated cells express CXCR3, whose cognate chemokines CXCL9/MIG, CXCL10/IP-10, and CXCL11/I-TAC. Little is known about expression of these lymph node (LN) metastases melanoma. We evaluated whether metastatic induces CXCR3-cognate human LN-derived tissues. In addition, as can be induced interferon (IFN), we type I or II IFNs (IFN-α...
Successful management of epithelial skin cancers with imiquimod 5% cream (Aldara), an immunomodulatory agent, led to speculation that it may promote immune response against melanoma. Studies, mostly case reports, have assessed the value as a topical treatment for dermal melanoma metastases prove difficult manage surgically. The precise imiquimod, however, in and subcutaneous remains unclear. A at our institution elucidates histopathologically progress despite excellent superficial dermis...
ASCO Guidelines provide recommendations with comprehensive review and analyses of the relevant literature for each recommendation, following guideline development process as outlined in Methodology Manual . follow Conflict Interest Policy Clinical Practice other guidance (“Guidance”) provided by is not a or definitive guide to treatment options. It intended voluntary use clinicians should be used conjunction independent professional judgment. Guidance may applicable all patients,...
To evaluate the sensitivity and clinical utility of intraoperative mobile gamma camera (MGC) imaging in sentinel lymph node biopsy (SLNB) melanoma.The false-negative rate for SLNB melanoma is approximately 17%, which failure to identify (SLN) a major cause. Intraoperative may aid detection SLN near primary site, ambiguous locations, after excision each SLN. The present pilot study reports outcomes with prototype MGC designed rapid image acquisition. We hypothesized that use would be feasible...
Total body photography may aid in melanoma screening but is not widely applied due to time and cost. We hypothesized that a near-simultaneous automated skin photo-acquisition system would be acceptable patients could rapidly obtain total images enable visualization of pigmented lesions.From February May 2009, study 20 volunteers was performed at the University Virginia test prototype 16-camera imaging booth built by research team guide development special purpose software. For each...
Peptide vaccines designed to stimulate melanoma-reactive CD4+ T cells can induce cell and antibody (Ab) responses, associated with enhanced overall survival. We hypothesized that adding toll-like receptor 3 agonist polyICLC an incomplete Freund's adjuvant (IFA) would be safe support strong, durable Ab responses. also oral low-dose metronomic cyclophosphamide (mCy) safe, reduce circulating regulatory (T-regs) further enhance immunogenicity.An adaptive design based on toxicity immune response...
Background A vaccine containing 6 melanoma-associated peptides to stimulate helper T cells (6MHP) is safe, immunogenic, and clinically active. phase I/II trial was designed evaluate safety immunogenicity of 6MHP vaccines plus programmed death 1 (PD-1) blockade. Participants methods with advanced melanoma received in an incomplete Freund’s adjuvant (6 over 12 weeks). Pembrolizumab administered intravenously every 3 weeks. Tumor biopsies at baseline day 22 were analyzed by multiplex...
Assessment of lymphatic status via sentinel lymph node (SLN) biopsy is an integral and crucial part melanoma surgical oncology. The most common technique for mapping preoperative planar scintigraphy injected gamma-emitting tracer followed by intraoperative localization using a non-imaging gamma probe with auditory feedback. In recent years, visualization SLNs in 3D has become possible coupling the to external system capable tracking its location orientation as it read out, thereby enabling...
9586 Background: In-transit melanoma (ITM) is a distinctive form of metastasis, marked by aggressive locoregional progression and characterized the entrapment tumor cells within lymphatic channels before reaching regional lymph nodes (LN). The mechanisms leading to trapping rather than distant metastasis are not well-understood. Previous research indicates clonal origin for ITM, suggesting specific early-stage genetic alterations may drive this clinical phenotype. In study, we sought...
A Caucasian baby girl presented at birth with a dark, irregular, raised skin lesion measuring approximately 2 cm in diameter on the medial aspect of her right leg (Fig 1). There was no history melanoma family and evidence mother. At two weeks age, she underwent an incisional biopsy community hospital. Histologic review showed superficial spreading invasive malignant Breslow thickness greater than 2.5 mm, positive deep margin. angiolymphatic invasion but definite ulceration. She referred to...