A5101878143- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Diet, Metabolism, and Disease
- Diabetes Treatment and Management
- Cardiovascular Health and Disease Prevention
- Endoplasmic Reticulum Stress and Disease
- Venous Thromboembolism Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Statistical Methods and Inference
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Cardiac Imaging and Diagnostics
- Primary Care and Health Outcomes
- PI3K/AKT/mTOR signaling in cancer
- Gastrointestinal motility and disorders
- Healthcare Systems and Practices
- Tuberculosis Research and Epidemiology
- Bariatric Surgery and Outcomes
- Mental Health Treatment and Access
- Vitamin C and Antioxidants Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Pharmacy and Medical Practices
- Cardiac Health and Mental Health
University of Chicago
2025
Shanghai Tenth People's Hospital
2025
Tongji University
2025
China Medical University
2010-2024
Fourth Affiliated Hospital of China Medical University
2019-2024
Guangdong Provincial Hospital of Traditional Chinese Medicine
2023
Guangzhou University of Chinese Medicine
2023
STATinMED (United States)
2011-2016
The Military General Hospital of Beijing PLA
2012-2015
First Hospital of China Medical University
2010-2014
Non-alcoholic fatty liver disease (NAFLD) represents a severe public health problem. Dysbiosis of gut microbiome has been identified as one the key environmental factors contributing to NAFLD. As an essential nutrition, Vitamin D (VD) plays important role in regulating microbiota based on its receptor (Vitamin Receptor, VDR) which is highly expressed gastrointestinal tract.Rats were fed with HFD (high-fat diet) for 12 weeks. And rats treated VD two times week by intraperitoneal injection H&E...
Summary Randomized experiments have been the gold standard for drawing causal inference. The conventional model-based approach has one of most popular ways analysing treatment effects from randomized experiments, which is often carried through inference certain model parameters. In this paper, we provide a systematic investigation analyses under randomization-based framework. This framework does not impose any distributional assumptions on outcomes, covariates and their dependence, utilizes...
Numerous researches have revealed a correlation between dietary factors and the development of constipation. This study aimed to investigate association oxidative balance score (DOBS) A cross-sectional was conducted by us based on National Health Nutrition Examination Survey (NHANES) from 2005 2010 including 31,034 individuals who completed constipation questionnaire. The DOBS calculated 16 factors, containing 14 antioxidants two prooxidants. Multiple logistic regression restricted cubic...
The incidence of non-alcoholic fatty liver disease (NAFLD) is increasing. Previous studies indicated that Liraglutide, glucagon-like peptide-1 analogue, could regulate glucose homeostasis as a valuable treatment for Type 2 Diabetes. However, the precise effect Liraglutide on NAFLD model in rats and mechanism remains unknown. In this study, we investigated molecular by which ameliorates hepatic steatosis high-fat diet (HFD)-induced rat vivo vitro.NALFD models hepatocyte HepG2 cells were...
To compare different rat models of sepsis at time points, based on pulmonary or extrapulmonary injury mechanisms, to identify a model which is more stable and reproducible cause sepsis-associated acute lung (ALI). Adult male Sprague-Dawley rats were subjected (1) cecal ligation puncture (CLP) with single (CLP1 group) two repeated through-and-through punctures (CLP2 group); (2) tail vein injection lipopolysaccharide (LPS) 10mg/kg (IV-LPS10 20mg/kg (IV-LPS20 (3) intratracheal instillation LPS...
Bariatric surgery is the most common and effective treatment of severe obesity; however, these bariatric procedures always result in detrimental effects on bone metabolism by underlying mechanisms. This study aims to investigate skeletal response explore whether <i>Clostridium butyricum</i> alleviates gut microbiota alteration–induced loss after surgery. Consequently, male SD rats received Roux-en-Y gastric bypass (RYGB) sleeve gastrectomy (SG) surgery, respectively, followed body weight...
Optic neuropathies cause irreversible vision loss as retinal ganglion cells (RGCs) die. Transplantation of pluripotent stem cell (PSC)-derived RGCs offers one potential therapeutic avenue to restore in patients suffering from optic neuropathy if the donor neurons survive long-term recipient eye and develop synaptic connections within inner plexiform layer (IPL) subcortical visual centers (1). Thus far, attempts at intravitreal RGC transplantation have been hampered by sequestration on...
Objective: To analyze and evaluate the effectiveness of individualized treatment regimen in therapy smear-positive retreatment pulmonary tuberculosis with mono-and poly-drug resistance, therefor to provide information on how develop rational for cases drug resistance. Methods: This was a multi-centered, prospective cohort study. Totally 254 sputum positive previous history during period from July 1, 2009 August 30, 2016 were included analysis. All randomly divided into 3 groups received...
Randomized experiments have been the gold standard for drawing causal inference. The conventional model-based approach has one of most popular ways analyzing treatment effects from randomized experiments, which is often carried through inference certain model parameters. In this paper, we provide a systematic investigation analyses under randomization-based framework. This framework does not impose any distributional assumptions on outcomes, covariates and their dependence, utilizes only...
To investigate the effects of glucagon-like peptide-1 (GLP-1) on liver oxidative stress injury using a rat model non-alcoholic fatty disease.Sixty male Sprague-Dawley rats were fed 12 weeks either diet normal chow (NC), for use as controls (n =15) or high-fat (HF), models =45).The NC administered saline, while HF treated with saline (NS), untreated =10), low-dose GLP-1 (LG, 50 mutg/kg; n mid-dose (MG, 100 high-dose (HG, 200 mug/kg; =10); all treatments lasted 4 weeks.The rats' weight, levels...
To compare the therapeutic effects between sitagliptin and voglibose both with sensor-augmented insulin pump (SAP) in newly diagnosed type 2 diabetes mellitus (T2DM).Fifty-six hospitalized T2DM patients Department of Endocrinology First Affiliated Hospital Dalian Medical University, hemoglobin A1c (HbA1c) value 9%-11%, were randomized into (S) group (n=28) (V) by block randomisation. Participants S received 100 mg per day, V 0.2 for 3 times day. All treated SAP 9 days. Real-time continuous...
After 4 weeks old male Sprague-Dawley rats were fed with normal diet and high-fat for 10 weeks,the treated metformin (200 mg/kg) 6 weeks. Insulin sensitivity was determined by hyperinsulinemic-euglycemic clamp technique.Realtime PCR western blot used to measure mRNA protein levels of chemerin in perirenal adipose tissue rats.The results showed that the expressions higher diet-induced insulin resistant compared ( both P＜0.05 ),and these incremental findings diminished treatment P＜0.01 ).The...
Objective To explore the expressions of endoplasmic reticulum stress(ERs)related factors including inositol requiring enzyme-1α(IRE1α), p-IRE1α, c-jun N-terminal Kinase(JNK), and p-JNK in rats with non-alcoholic fatty liver disease, to investigate effect intervention glucagon-like peptide 1(GLP-1)analogue. Methods Forty male Sprague-Dawley were divided into normal chow group(n=15)and high-fat diet group(n=25). After 12 weeks, 5 each group used assess establishment rat models disease....
Objective To investigate the change of glucose variability and relationship between severity coronary artery stenosis in patients with type 2 diabetes mellitus(T2DM) acute syndrome(ACS). Methods A total 64 hospitalized T2DM ACS were recruited from November 2010 to October 2011. Thirty cases(19 males 11 females, aged (60±11) yrs) underwent emergency angiography (group A), 34 cases(15 19 (59±10) stable condition selective after one week(group B). Twenty cases without same period set as...