A5101458657- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Diabetes and associated disorders
- Virus-based gene therapy research
- Retinal Imaging and Analysis
- Bone health and osteoporosis research
- Protein Tyrosine Phosphatases
- RNA Interference and Gene Delivery
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Advanced Technologies and Applied Computing
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Neurological Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- FOXO transcription factor regulation
- Apelin-related biomedical research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- CAR-T cell therapy research
- Genetics, Aging, and Longevity in Model Organisms
- Pharmacology and Obesity Treatment
- ATP Synthase and ATPases Research
- Bone health and treatments
Weifang Medical University
2025
Dalian Medical University
2008-2021
First Affiliated Hospital of Dalian Medical University
2008-2021
Wannan Medical College
2018
[b]BACKGROUND[/b] Previous studies have shown that T cell immunoglobulin domain and mucin-3 (Tim-3) interleukin-17 (IL-17) are implicated in the development of several autoimmune diseases. However, it is unclear whether these proteins contribute to pathogenesis systemic lupus erythematosus (SLE). The purpose this study was evaluate SLE patient serum Tim-3 IL-17 levels, assess correlations between major clinical parameters SLE. [b]MATERIAL AND METHODS[/b] Overall, 55 patients healthy controls...
To assess the efficacy and safety of sitagliptin compared with voglibose added to combined metformin insulin in patients newly diagnosed type 2 diabetes (T2DM).In this 12-week prospective, randomized, parallel trial, 70 T2DM glycosylated hemoglobin (HbA1c) ≥9% and/or fasting plasma glucose (FPG) ≥11.1 mmol/L were randomized (1:1) receive 100 mg per day + glargine or 0.2 three times daily glargine. Change HbA1c at week 12 was primary endpoint.The mean baseline 11.0% patients. The changes from...
The aim of the present study was to explore associations among glycemic excursions, glycated hemoglobin (HbA1c) and high-sensitivity C-reactive protein (hs-CRP) in patients with poorly controlled type 2 diabetes mellitus (T2DM) using a continuous glucose monitoring system (CGMS). Sixty‑three T2DM whose HbA1c levels were >7% wore CGMS device for 72 h. According their levels, divided into three groups as follows: Group A (HbA1c ≤9.32%), group B (9.32%< ≤11.76%) C >11.76%). Patients also two...
The present study evaluated the efficacy of switching from premixed insulin or an analogue to glargine plus oral antidiabetic drugs (OADs) in patients with type 2 diabetes mellitus (T2DM). feasibility and suitability regimen was examined based on islet function. Patients T2DM (n=30) treated stable doses for eight weeks were divided into two groups according Group A had a h C peptide (2hCP)/fasting (FCP) ratio ≤3, whereas group B 2hCP/FCP >3. Eight following switch OADs, significant decrease...
To assess the association of type 2 diabetes mellitus (T2DM) and insulin glargine treatment with bone mineral density (BMD) in Chinese people.This retrospective study included 50 subjects T2DM: 25 received oral glucose-lowering medication (ORL group), combination injection (CGI group). Thirty non-diabetic control were also included. BMD was measured at lumbar vertebrae 1-4 (L1-L4), spine (sBMD) results summary (L2-L4), femoral neck trochanter by dual-energy x-ray absorptiometry.Compared...
To compare the therapeutic effects between sitagliptin and voglibose both with sensor-augmented insulin pump (SAP) in newly diagnosed type 2 diabetes mellitus (T2DM).Fifty-six hospitalized T2DM patients Department of Endocrinology First Affiliated Hospital Dalian Medical University, hemoglobin A1c (HbA1c) value 9%-11%, were randomized into (S) group (n=28) (V) by block randomisation. Participants S received 100 mg per day, V 0.2 for 3 times day. All treated SAP 9 days. Real-time continuous...
Objective: To compare the efficacy and safety of a twice daily injection insulin aspart (BIAsp) 30 BIAsp50 in patients with type 2 diabetes mellitus (T2DM) poorly controlled oral hypoglycemic agents (OHAs).Methods: In this 12 week prospective, randomized, parallel trial, total 80 T2DM patients, 59 ± 10 years old disease duration 9.3 6.6 HbA1c >7% despite large doses metformin sulfonylurea administration, were randomized to receive BIAsp30 (n = 40) or 40). The primary endpoint was change at...
肾素-血管紧张素-醛固酮系统（RAAS）的最终活性产物血管紧张素Ⅱ（AngⅡ），通过激活特殊AngⅡ受体，调节心脏收缩力、细胞耦合以及电冲动传播，参与心脏重构、发育和心肌细胞凋亡。随着研究的不断深入，心脏和其他组织局部RAAS概念被逐渐接受。目前有充足证据表明，RAAS成分在心血管组织中表达并发挥作用。但是，心脏不同部位的内分泌功能是否有所差异以及局部的内分泌功能能否影响到全身RAAS，还需进一步研究。.
Objective To evaluate the efficacy and safety of short-term sensor-augmented insulin-pump (SAP) therapy for poorly controlled patients with type 1 diabetes mellitus (T1DM). Methods Sixty T1DM glycosylated hemoglobin (HbA1c)>9.0% were randomly assigned to 2 groups treated SAP or multiple daily insulin injection (MDI) 6 days, then all converted MDI therapy. Results Compared group before therapy, mean blood glucose concentration (MBG), SD glucose, amplitude glycemic excursion...
Objective To investigate the insulin resistance and β cell function in short disease duration naive type 2 diabetic patients treated with oral hypoglycemic agents (OHA),insulin or combining OHA.Methods Ninety newly diagnosed (the duration≤1 year) were randomly divided into three groups,treated OHA,insulin therapy separately.Each group included 30 cases Was put on intensive glycemic control.The targets for control fasting blood glucose less than 6.0 mmoL/L,and two hours postprandial 8.0...
Background/Aim. Macroangiopathy is the major cause of death and disability in type 2 diabetic patients. Studies have shown that liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, can protect cardiovascular system by inhibiting chronic inflammation diabetes. However, study about effects liraglutide on peripheral blood vessels leukocytes has not been reported yet. The aim this was to determine vasculoprotective effect, vascular protection mechanism action addition its...