A5020561748- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Endoplasmic Reticulum Stress and Disease
- Hematopoietic Stem Cell Transplantation
- Phagocytosis and Immune Regulation
- Autophagy in Disease and Therapy
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Multiple Myeloma Research and Treatments
- Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- RNA Interference and Gene Delivery
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Mitochondrial Function and Pathology
- Glycosylation and Glycoproteins Research
- Blood groups and transfusion
- Peptidase Inhibition and Analysis
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Platelet Disorders and Treatments
University of Virginia Medical Center
2024
University of Virginia
2023
Medical University of South Carolina
2017-2022
University of South Carolina
2019-2020
Discovery Institute
2016
Sanford Burnham Prebys Medical Discovery Institute
2016
University of California, Los Angeles
2012-2014
Mitochondria and endoplasmic reticulum (ER) share structural functional networks activate well-orchestrated signaling processes to shape cells' fate function. While persistent ER stress (ERS) response leads mitochondrial collapse, moderate ERS promotes Strategies boost antitumor T-cell function by targeting ER-mitochondria cross-talk have not yet been exploited. Here, we used carbon monoxide (CO), a short-lived gaseous molecule, test whether engaging conditions can improve functions in T...
Abstract Increasing angiogenesis has long been considered a therapeutic target for improving heart function after injury such as acute myocardial infarction. However, gene, protein and cell therapies to increase microvascularization have not successful, most likely because the studies failed achieve regulated concerted expression of pro-angiogenic angiostatic factors needed produce functional microvasculature. Here, we report that transcription factor RBPJ is homoeostatic repressor multiple...
Multiple myeloma (MM), a plasma cell malignancy, is the second most prevalent hematologic malignancy in US. Although much effort has been made trying to understand etiology and complexities of this disease with hope developing effective therapies, MM remains incurable at time. Because their antiproliferative proapoptotic activities, interferons (IFNs) have used treat various malignancies, including MM. some success observed, inherent toxicities IFNs limit efficacy. To address problem, we...
(a) Rapamycin nanotherapeutic pre-treatment improves tracheal allograft outcome after transplantation. (b) Nanotherapy reduces aortic vasculopathy. (c) Dose dependency of the nanotherapy in interposition allografts.
Early insults associated with cardiac transplantation increase the immunogenicity of donor microvascular endothelial cells (ECs), which interact recipient alloreactive memory T and promote responses leading to allograft rejection. Thus, modulating EC could potentially alter cell responses. Recent studies have shown mitochondrial fusion/fission alters immune phenotype. Here, we assess whether reduces EC-T interactions. By knocking down DRP1, a fission protein, or by using small molecules M1,...
Microvascular endothelial cells (ECs) are central to an allograft's immunogenicity. Cold ischemia and reperfusion injury associated with static cold storage warm activates ECs increases the immunogenicity of allograft. After reperfusion, mitochondrial permeability transition pore (mPTP) opening contributes dysfunction in allograft, which correlates alloimmune rejection. Current understanding this relationship, however, centers on whole allograft instead ECs. This study aimed elucidate...
e23306 Background: Randomized clinical trials are the “gold standard”, but expensive and not always practice changing. Umbilical cord blood (UCB) haploidentical (haplo) donor sources for hematopoietic cell transplant (HCT) patients who do have a fully matched donor. The Blood Marrow Transplant Clinical Trials Network (CTN) 1101 trial (2012-2018) compared outcomes of double UCB haplo bone marrow (BM) transplantation. showed lower two-year overall survival after to (46% vs 57%, p = 0.04)....
Immune thrombocytopenia (ITP) is an acquired resulting from immune-mediated platelet destruction via antiplatelet antibodies and T cells. Medical management of ITP includes corticosteroids multiple other adjunct therapies, with splenectomy generally being reserved for severe, refractory cases. In this clinical case report, we describe the evaluation a 35-year-old male history prior traumatic splenic injury who presented to emergency department endorsing easy bruising petechial rash,...
Abstract Endoplasmic reticulum (ER) stress induced by external or internal stimuli, activates a number of well-orchestrated cellular signaling processes aiming either to promote cell apoptosis restore function and resolve the stress. In tumor microenvironment, induction ER is known dampen antitumor activity T cells reducing their mitochondrial function. However, if magnitude governs fate unknown. Using melanoma antigen gp100 reactive cells, we found that low level enhances stemness promotes...
Abstract A number of external or internal stimuli cause endoplasmic reticulum (ER) stress conditions. In response to ER stress, stressed cells activate well-orchestrated cellular signaling processes resolve the remove itself by triggering apoptosis. tumor microenvironment, induction sustained is known dampen antitumor activity T cells. However, how respond suboptimal unknown. Using melanoma antigen gp100 reactive cells, we found that transiently protein kinase R-like (PERK) dependent network...