Yitao Tang
A5077448377- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Renal and related cancers
- Protein Degradation and Inhibitors
- Cancer-related gene regulation
- Renal cell carcinoma treatment
- CRISPR and Genetic Engineering
- RNA and protein synthesis mechanisms
- Bone Tissue Engineering Materials
- Genetics, Bioinformatics, and Biomedical Research
- Bone Metabolism and Diseases
- Genomics and Chromatin Dynamics
- PARP inhibition in cancer therapy
- Health, Environment, Cognitive Aging
- Viral Infectious Diseases and Gene Expression in Insects
- Advanced biosensing and bioanalysis techniques
- PI3K/AKT/mTOR signaling in cancer
- Bone and Dental Protein Studies
- Signaling Pathways in Disease
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Advanced Proteomics Techniques and Applications
- Machine Learning in Bioinformatics
- Venomous Animal Envenomation and Studies
The University of Texas MD Anderson Cancer Center
2020-2025
The University of Texas Health Science Center at Houston
2022-2025
Guilin Medical University
2024
Southern Medical University
2023
Nanfang Hospital
2023
Nanchang University
2023
Sichuan University
2021-2022
BioReliance (United States)
2018-2019
Shanghai First Maternity and Infant Hospital
2014
Shanghai Tenth People's Hospital
2013
Tumor mutational burden and heterogeneity has been suggested to fuel resistance many targeted therapies. The cytosine deaminase APOBEC proteins have implicated in the signatures of more than 70% human cancers. However, mechanism underlying how cancer cells hijack mediated mutagenesis machinery promote tumor heterogeneity, thereby foster therapy remains unclear. We identify SYNCRIP as an endogenous molecular brake which suppresses APOBEC-driven prostate (PCa). Overactivated APOBEC3B,...
Abstract Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms which cancer exploit the regulatory machinery acquire therapy resistance remain poorly understood. We identified zinc finger protein 397 (ZNF397) as a bona fide coactivator of androgen receptor (AR), essential for transcriptional program governing AR-driven luminal lineage. ZNF397...
Digital light processing (DLP)-based 3D printing technique holds promise in fabricating scaffolds with high precision. Here raw calcium phosphate (CaP) powders were modified by 5.5% monoalcohol ethoxylate (MAEP) to ensure solid loading and low viscosity. The rheological tests found that photocurable slurries composed of 50 wt% CaP 2 toners suitable for DLP printing. Based on geometric models designed computer-aided design (CAD) system, three printed ceramics distinct macroporous structures...
Poly(ADP-ribose) polymerase inhibitors (PARP inhibitors) have had an increasing role in the treatment of ovarian and breast cancers. PARP are selectively active cells with homologous recombination DNA repair deficiency caused by mutations BRCA1/2 other pathway genes. Cancers proficiency respond poorly to inhibitors. that initially eventually develop drug resistance. We identified salt-inducible kinase 2 (SIK2) inhibitors, ARN3236 ARN3261, which decreased double-strand break (DSB) functions...
Abstract Currently the clinical efficacy of colorectal cancer (CRC) which is most common malignant tumors over world has not reached an ideal level. Cetuximab, monoclonal antibody targeting extracellular domain EGFR, shown its great in promotion apoptosis and inhibition tumor cells-like characteristics numerous cancers. However certain KRAS wild-type CRC patients unexpectedly show cetuximab resistance specific mechanism remains unclear. Circular RNAs (circRNAs) as promising novel type...
The mutational landscape of phylogenetically ultraconserved elements (UCEs), especially those in noncoding DNAs (ncUCEs), and their functional relevance cancers remain poorly characterized. Here, we perform a systematic analysis whole-genome in-house targeted UCE sequencing datasets from more than 3000 patients with cancer 13,736 UCEs demonstrate that ncUCE somatic alterations are common. Using multiplexed CRISPR knockout screen colorectal cells, show the loss several altered ncUCEs...
Functional proteomics provides critical insights into cancer mechanisms, facilitating the discovery of novel biomarkers and therapeutic targets. We have developed a comprehensive functional resource using reverse phase protein arrays, incorporating data from nearly 8000 patient samples The Cancer Genome Atlas approximately 900 Cell Line Encyclopedia. Our dataset includes curated panel 500 high-quality antibodies, covering all major hallmark pathways. To enhance accessibility analytic power...
Recent studies on osteoimmunology have revealed the indispensable role of immune cells in osteogenesis. The surface topography biomaterials plays a critical regulating cellular behaviors; however, little attention is paid to its effects response. Three dense hydroxyapatite (HA) disks with grain size nano-scale (∼100 nm) submicron (∼500 range were prepared investigate their macrophage polarization and functional status. It was found that HA ceramics nano-topography promoted phenotypic...
The robust detection of structural variants in mammalian genomes remains a challenge. It is particularly difficult the case genetically unstable Chinese hamster ovary (CHO) cell lines with only draft genome assemblies available. We explore potential CRISPR/Cas9 system for targeted capture genomic loci containing integrated vectors CHO-K1-based followed by next generation sequencing (NGS), and compare it to popular target-enrichment methods whole (WGS). Three different CRISPR/Cas9-based...
Micro-vibration stimulation (MVs) plays a critical role in regulating the inflammatory responses of macrophages to BCP ceramics and further inducing osteogenic differentiation BMMSCs paracrine manner.
Nucleosome organization determines the chromatin state, which in turn controls gene expression or silencing. remodeling occurs during somatic cell reprogramming, but it is still unclear to what degree re-established nucleosome of induced pluripotent stem cells (iPSCs) resembles embryonic (ESCs), and whether iPSCs inherit some residual from parental fibroblast cells. We generated genome-wide maps mouse ESCs reprogrammed belonging three different germ layers using a secondary reprogramming...
Abstract Motivation The efficiency of CRISPR/Cas9-mediated protein knockout is determined by three factors: sequence-specific sgRNA activity, frameshift probability and the characteristics targeted amino acids. A number computational methods have been developed for predicting from different perspectives. However, an integrative method that combines all factors rational selection still lacking. Results We GuidePro, a two-layer ensemble predictor enables integration multiple prioritization...
<div>Abstract<p>Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms which cancer exploit the regulatory machinery acquire therapy resistance remain poorly understood. We identified zinc finger protein 397 (ZNF397) as a <i>bona fide</i> coactivator of androgen receptor (AR), essential for transcriptional program governing...
<p>Table S5. Lineage-Specific and AR Target Gene Signatures</p>
<p>Table S6. Key Resources</p>
<p>Table S5. Lineage-Specific and AR Target Gene Signatures</p>
<p>Table S4. Candidate Resistance Driver Genes in ZNF397-KO Cells</p>
<p>Table S6. Key Resources</p>
<p>Table S1. Significantly Altered AR ChIP-seq Peaks in ZNF397-KO Cells</p>
<p>Table S3. Significantly Enriched or Depleted Signaling Pathways in GSEA Analysis</p>
<div>Abstract<p>Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming that allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms which cancer exploit the regulatory machinery acquire therapy resistance remain poorly understood. We identified zinc finger protein 397 (ZNF397) as a <i>bona fide</i> coactivator of androgen receptor (AR), essential for transcriptional program governing...
<p>Table S2. Differentially Expressed Genes in ZNF397-KO Cells</p>
<p>Table S3. Significantly Enriched or Depleted Signaling Pathways in GSEA Analysis</p>