A5101796019- PARP inhibition in cancer therapy
- Geochemistry and Elemental Analysis
- Renal and related cancers
- Pluripotent Stem Cells Research
- Retinal Development and Disorders
- Advanced biosensing and bioanalysis techniques
- Circadian rhythm and melatonin
- Epigenetics and DNA Methylation
- Prostate Cancer Treatment and Research
- Signaling Pathways in Disease
- Connexins and lens biology
- Microbial Metabolic Engineering and Bioproduction
- Plant-based Medicinal Research
- Heavy metals in environment
- Electrochemical sensors and biosensors
- Single-cell and spatial transcriptomics
- Viral Infectious Diseases and Gene Expression in Insects
- CRISPR and Genetic Engineering
- Bioactive Natural Diterpenoids Research
- Traditional Chinese Medicine Analysis
- Cancer-related gene regulation
- Metabolism, Diabetes, and Cancer
- Electrochemical Analysis and Applications
- Animal Genetics and Reproduction
- Biochemical and Molecular Research
University of Virginia
2023
Princess Margaret Cancer Centre
2023
University Health Network
2023
University of Toronto
2023
Guangzhou Institutes of Biomedicine and Health
2021-2022
Zhejiang University
2020-2022
Chinese Academy of Sciences
2022
Center for Excellence in Molecular Plant Sciences
2022
University of Chinese Academy of Sciences
2021
Hebei Medical University
2010
Tumor mutational burden and heterogeneity has been suggested to fuel resistance many targeted therapies. The cytosine deaminase APOBEC proteins have implicated in the signatures of more than 70% human cancers. However, mechanism underlying how cancer cells hijack mediated mutagenesis machinery promote tumor heterogeneity, thereby foster therapy remains unclear. We identify SYNCRIP as an endogenous molecular brake which suppresses APOBEC-driven prostate (PCa). Overactivated APOBEC3B,...
Abstract Multiple pluripotent states have been described in mouse and human stem cells. Here, we apply single-cell RNA-seq to a newly established BMP4 induced primed naïve transition (BiPNT) system show that the reset is not direct reversal of cell fate but goes through primordial germ cell-like cells (PGCLCs) state. We first epiblast bifurcate into c-Kit + − trophoblast-like cells, among which, branch undergoes further PGCLCs intermediate capable spermatogenesis vivo. Mechanistically, DOT1L...
Accumulating clinical evidence indicates that diabetic liver cancer patients are less sensitive to intra-arterial chemotherapy than non-diabetic patients. However, the underlying mechanism remains largely uncharacterized. Here, we report hyperglycemia inhibits AMPK pathway and subsequently reduces ADR induced DNA damage, resulting in decreased chemotherapeutic sensitivity of Adriamycin (ADR). HepG2 Bel-7402 cells were treated with various glucose conditions then subjected cell proliferation...
Exploring the factors that simultaneously increase accumulation of pollutants in cells organisms to restrict toxic effects ecological environments has become a focus research aimed at protecting environments. Here, we found organic, inorganic, and emerging [e.g., benzo(a)pyrene (BaP), cadmium (Cd), rare earth elements (REEs)] leaf plants grown Nanjing (with 4.31×10 -9 g/L REEs rainwater) was sharply increased. Particularly, BaP, Cd, 567-1022%, 547-922%, 972-1392%, respectively, those Haikou...
Abstract Cancer cells exhibit phenotypical plasticity and epigenetic reprogramming, which allows them to evade lineage-dependent targeted treatments by adopting lineage plasticity. The underlying mechanisms cancer exploit the regulatory machinery acquire therapy resistance remain poorly understood. We identified Zinc Finger Protein 397 (ZNF397) as a bona fide co-activator of androgen receptor (AR), essential for transcriptional program governing AR-driven luminal lineage. ZNF397 deficiency...
Dry age-related macular degeneration (AMD) has been proved to be correlated oxidative stress and long-term blue light exposure. Mitochondria are dynamic organelles undergoing continuous fission fusion process keep the normal structure functions maintain reactive oxygen species (ROS) within range. The current study aims elaborates mechanism of mitochondrial dynamics alteration in retina under exposure vivo vitro. In our study, six-month-old C57BL/6 mice were exposed (450 nm, 800 lx). After...
Abstract Single cell analysis provides clarity unattainable with bulk approaches. Here we apply single RNA-seq to a newly established BMP4 induced mouse primed naive transition (Bi-PNT) system and show that the reset is not direct reversal of fate but through developmental intermediates. We first mEpiSCs bifurcate into c-Kit+ naïve c-Kit- placenta-like cells, among which, branch undergoes further primordial germ cell-like cells (PGCLCs) intermediate capable spermatogenesis in vivo. Indeed,...